Lai MC, Lombardo MV, Baron-Cohen S. Autism. Lancet 2014, 383: 896–910.

Article  PubMed  Google Scholar 

Hirota T, King BH. Autism spectrum disorder: A review. JAMA 2023, 329: 157–168.

Article  CAS  PubMed  Google Scholar 

Höfer J, Hoffmann F, Kamp-Becker I, Poustka L, Roessner V, Stroth S. Pathways to a diagnosis of autism spectrum disorder in Germany: A survey of parents. Child Adolesc Psychiatry Ment Health 2019, 13: 16.

Article  PubMed  PubMed Central  Google Scholar 

De Rubeis S, Buxbaum JD. Genetics and genomics of autism spectrum disorder: Embracing complexity. Hum Mol Genet 2015, 24: R24–R31.

Article  PubMed  PubMed Central  Google Scholar 

Sanders SJ, Xin H, Willsey AJ, Ercan-Sencicek AG, Samocha KE, Cicek AE, et al. Insights into autism spectrum disorder genomic architecture and biology from 71 risk loci. Neuron 2015, 87: 1215–1233.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Durand CM, Betancur C, Boeckers TM, Bockmann J, Chaste P, Fauchereau F, et al. Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders. Nat Genet 2007, 39: 25–27.

Article  CAS  PubMed  Google Scholar 

Moessner R, Marshall CR, Sutcliffe JS, Skaug J, Pinto D, Vincent J, et al. Contribution of SHANK3 mutations to autism spectrum disorder. Am J Hum Genet 2007, 81: 1289–1297.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gauthier J, Spiegelman D, Piton A, Lafrenière RG, Laurent S, St-Onge J, et al. Novel de novo SHANK3 mutation in autistic patients. Am J Med Genet Part B Neuropsychiatr Genet 2009, 150B: 421–424.

Article  CAS  Google Scholar 

Wang X, McCoy PA, Rodriguiz RM, Pan Y, Je HS, Roberts AC, et al. Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3. Hum Mol Genet 2011, 20: 3093–3108.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kouser M, Speed HE, Dewey CM, Reimers JM, Widman AJ, Gupta N, et al. Loss of predominant Shank3 isoforms results in hippocampus-dependent impairments in behavior and synaptic transmission. J Neurosci 2013, 33: 18448–18468.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee J, Chung C, Ha S, Lee D, Kim DY, Kim H, et al. Shank3-mutant mice lacking exon 9 show altered excitation/inhibition balance, enhanced rearing, and spatial memory deficit. Front Cell Neurosci 2015, 9: 94.

Article  PubMed  PubMed Central  Google Scholar 

Peça J, Feliciano C, Ting JT, Wang W, Wells MF, Venkatraman TN, et al. Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature 2011, 472: 437–442.

Article  PubMed  PubMed Central  Google Scholar 

Guo B, Chen J, Chen Q, Ren K, Feng D, Mao H, et al. Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice. Nat Neurosci 2019, 22: 1223–1234.

Article  CAS  PubMed  Google Scholar 

Naisbitt S, Kim E, Tu JC, Xiao B, Sala C, Valtschanoff J, et al. Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin. Neuron 1999, 23: 569–582.

Article  CAS  PubMed  Google Scholar 

Sheng M, Kim E. The Shank family of scaffold proteins. J Cell Sci 2000, 113(Pt 11): 1851–1856.

Article  CAS  PubMed  Google Scholar 

Monteiro P, Feng G. SHANK proteins: Roles at the synapse and in autism spectrum disorder. Nat Rev Neurosci 2017, 18: 147–157.

Article  CAS  PubMed  Google Scholar 

Bozdagi O, Sakurai T, Papapetrou D, Wang X, Dickstein DL, Takahashi N, et al. Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication. Mol Autism 2010, 1: 15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu Y, Sousa AMM, Gao T, Skarica M, Li M, Santpere G, et al. Spatiotemporal transcriptomic divergence across human and macaque brain development. Science 2018, 362: eaat8077.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roussignol G, Ango F, Romorini S, Tu JC, Sala C, Worley PF, et al. Shank expression is sufficient to induce functional dendritic spine synapses in aspiny neurons. J Neurosci 2005, 25: 3560–3570.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Verpelli C, Dvoretskova E, Vicidomini C, Rossi F, Chiappalone M, Schoen M, et al. Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J Biol Chem 2011, 286: 34839–34850.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yi F, Danko T, Botelho SC, Patzke C, Pak C, Wernig M, et al. Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons. Science 2016, 352: aaf2669.

Article  PubMed  PubMed Central  Google Scholar 

Wang Y, Chiola S, Yang G, Russell C, Armstrong CJ, Wu Y, et al. Modeling human telencephalic development and autism-associated SHANK3 deficiency using organoids generated from single neural rosettes. Nat Commun 2022, 13: 5688.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tamamaki N, Yanagawa Y, Tomioka R, Miyazaki JI, Obata K, Kaneko T. Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse. J Comp Neurol 2003, 467: 60–79.

Article  CAS  PubMed  Google Scholar 

He X, Li J, Zhou G, Yang J, McKenzie S, Li Y, et al. Gating of hippocampal rhythms and memory by synaptic plasticity in inhibitory interneurons. Neuron 2021, 109: 1013-1028.e9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo B, Xi K, Mao H, Ren K, Xiao H, Hartley ND, et al. CB1R dysfunction of inhibitory synapses in the ACC drives chronic social isolation stress-induced social impairments in male mice. Neuron 2024, 112: 441–457.e6.

Article  CAS  PubMed  Google Scholar 

Boeckers TM, Winter C, Smalla KH, Kreutz MR, Bockmann J, Seidenbecher C, et al. Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family. Biochem Biophys Res Commun 1999, 264: 247–252.

Article  CAS  PubMed  Google Scholar 

Botvinick MM, Cohen JD, Carter CS. Conflict monitoring and anterior cingulate cortex: An update. Trends Cogn Sci 2004, 8: 539–546.

Article  PubMed  Google Scholar 

Etkin A, Egner T, Kalisch R. Emotional processing in anterior cingulate and medial prefrontal cortex. Trends Cogn Sci 2011, 15: 85–93.

Article  PubMed  Google Scholar 

Haber SN, Behrens TEJ. The neural network underlying incentive-based learning: Implications for interpreting circuit disruptions in psychiatric disorders. Neuron 2014, 83: 1019–1039.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ren D, Li JN, Qiu XT, Wan FP, Wu ZY, Fan BY, et al. Anterior cingulate cortex mediates hyperalgesia and anxiety induced by chronic pancreatitis in rats. Neurosci Bull 2022, 38: 342–358.

Article  CAS