Burroughs AM, Iyer LM, Aravind L. Structure and evolution of ubiquitin and ubiquitin-related domains. Methods Mol Biol 2012, 832: 15–63.

Article  PubMed  CAS  Google Scholar 

Buetow L, Huang DT. Structural insights into the catalysis and regulation of E3 ubiquitin ligases. Nat Rev Mol Cell Biol 2016, 17: 626–642.

Article  PubMed  PubMed Central  CAS  Google Scholar 

McKinnon C, Tabrizi SJ. The ubiquitin-proteasome system in neurodegeneration. Antioxid Redox Signal 2014, 21: 2302–2321.

Article  PubMed  CAS  Google Scholar 

Pérez-Villegas EM, Ruiz R, Bachiller S, Ventura F, Armengol JA, Rosa JL. The HERC proteins and the nervous system. Semin Cell Dev Biol 2022, 132: 5–15.

Article  PubMed  Google Scholar 

Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE. Ferroptosis: An iron-dependent form of nonapoptotic cell death. Cell 2012, 149: 1060–1072.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, et al. Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease. Cell 2017, 171: 273–285.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Stockwell BR, Jiang X. The chemistry and biology of ferroptosis. Cell Chem Biol 2020, 27: 365–375.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hirschhorn T, Stockwell BR. The development of the concept of ferroptosis. Free Radic Biol Med 2019, 133: 130–143.

Article  PubMed  CAS  Google Scholar 

Yang WS, Stockwell BR. Ferroptosis: Death by lipid peroxidation. Trends Cell Biol 2016, 26: 165–176.

Article  PubMed  CAS  Google Scholar 

Ratan RR. The chemical biology of ferroptosis in the central nervous system. Cell Chem Biol 2020, 27: 479–498.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Reichert CO, de Freitas FA, Sampaio-Silva J, Rokita-Rosa L, Barros PL, Levy D, et al. Ferroptosis mechanisms involved in neurodegenerative diseases. Int J Mol Sci 2020, 21: 8765.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Qian ZM, Ke Y. Brain iron transport. Biol Rev Camb Philos Soc 2019, 94: 1672–1684.

Article  PubMed  Google Scholar 

Stephenson E, Nathoo N, Mahjoub Y, Dunn JF, Yong VW. Iron in multiple sclerosis: Roles in neurodegeneration and repair. Nat Rev Neurol 2014, 10: 459–468.

Article  PubMed  CAS  Google Scholar 

Liu J, Kang R, Tang D. Signaling pathways and defense mechanisms of ferroptosis. FEBS J 2022, 289: 7038–7050.

Article  PubMed  CAS  Google Scholar 

Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell 2014, 156: 317–331.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Brigelius-Flohé R, Maiorino M. Glutathione peroxidases. Biochim Biophys Acta 1830, 2013: 3289–3303.

Google Scholar 

Jiang X, Stockwell BR, Conrad M. Ferroptosis: Mechanisms, biology and role in disease. Nat Rev Mol Cell Biol 2021, 22: 266–282.

Article  PubMed  PubMed Central  Google Scholar 

He F, Zhang P, Liu J, Wang R, Kaufman RJ, Yaden BC, et al. ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis. J Hepatol 2023, 79: 362–377.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang W, Sun Y, Bai L, Zhi L, Yang Y, Zhao Q, et al. RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11. J Clin Invest 2021, 131: e152067.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jiang L, Kon N, Li T, Wang SJ, Su T, Hibshoosh H, et al. Ferroptosis as a p53-mediated activity during tumour suppression. Nature 2015, 520: 57–62.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gao R, Kalathur RKR, Coto-Llerena M, Ercan C, Buechel D, Shuang S, et al. YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis. EMBO Mol Med 2021, 13: e14351.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P, et al. BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nat Cell Biol 2018, 20: 1181–1192.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Yuan Y, Zhai Y, Chen J, Xu X, Wang H. Kaempferol ameliorates oxygen-glucose deprivation/reoxygenation-induced neuronal ferroptosis by activating Nrf2/SLC7A11/GPX4 axis. Biomolecules 2021, 11: 923.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu T, Jiang L, Tavana O, Gu W. The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11. Cancer Res 2019, 79: 1913–1924.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li G, Zhou C, Wang L, Zheng Y, Zhou B, Li G, et al. MitoCur-1 induces ferroptosis to reverse vemurafenib resistance in melanoma through inhibition of USP14. Pigment Cell Melanoma Res 2024, 37: 316–328.

Article  PubMed  CAS  Google Scholar 

Tang J, Long G, Hu K, Xiao D, Liu S, Xiao L, et al. Targeting USP8 inhibits O-GlcNAcylation of SLC7A11 to promote ferroptosis of hepatocellular carcinoma via stabilization of OGT. Adv Sci 2023, 10: e2302953.

Article  Google Scholar 

Wang Z, Xia Y, Wang Y, Zhu R, Li H, Liu Y, et al. The E3 ligase TRIM26 suppresses ferroptosis through catalyzing K63-linked ubiquitination of GPX4 in glioma. Cell Death Dis 2023, 14: 695.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang J, Qiu Q, Wang H, Chen C, Luo D. TRIM46 contributes to high glucose-induced ferroptosis and cell growth inhibition in human retinal capillary endothelial cells by facilitating GPX4 ubiquitination. Exp Cell Res 2021, 407: 112800.

Article  PubMed  CAS  Google Scholar 

Zhang J, Xie H, Yao J, Jin W, Pan H, Pan Z, et al. TRIM59 promotes steatosis and ferroptosis in non-alcoholic fatty liver disease via enhancing GPX4 ubiquitination. Hum Cell 2023, 36: 209–222.

Article  PubMed  CAS  Google Scholar 

Zhao X, Zhou T, Wang Y, Bao M, Ni C, Ding L, et al. Trigred motif 36 regulates neuroendocrine differentiation of prostate cancer via HK2 ubiquitination and GPx4 deficiency. Cancer Sci 2023, 114: 2445–2459.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wu K, Yan M, Liu T, Wang Z, Duan Y, Xia Y, et al. Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting f