Type 2 Diabetes Mellitus Exacerbates Pathological Processes of Parkinson's Disease: Insights from Signaling Pathways Mediated by Insulin Receptors

Hayes MT. Parkinson’s disease and Parkinsonism. Am J Med 2019, 132: 802–807.

Article  PubMed  Google Scholar 

Ejma M, Madetko N, Brzecka A, Guranski K, Alster P, Misiuk-Hojło M. The links between Parkinson’s disease and cancer. Biomedicines 2020, 8: 416.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fasano A, Visanji NP, Liu LWC, Lang AE, Pfeiffer RF. Gastrointestinal dysfunction in Parkinson’s disease. Lancet Neurol 2015, 14: 625–639.

Article  PubMed  CAS  Google Scholar 

Zhou Z, Zhou R, Zhang Z, Li K. The association between vitamin D status, vitamin D supplementation, sunlight exposure, and Parkinson’s disease: A systematic review and meta-analysis. Med Sci Monit 2019, 25: 666–674.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Müller T, van Laar T, Cornblath DR, Odin P, Klostermann F, Grandas FJ, et al. Peripheral neuropathy in Parkinson’s disease: Levodopa exposure and implications for duodenal delivery. Parkinsonism Relat Disord 2013, 19: 501–507.

Article  PubMed  Google Scholar 

Kim YE, Lee WW, Yun JY, Yang HJ, Kim HJ, Jeon BS. Musculoskeletal problems in Parkinson’s disease: Neglected issues. Parkinsonism Relat Disord 2013, 19: 666–669.

Article  PubMed  Google Scholar 

Reich SG, Savitt JM. Parkinson’s disease. Med Clin N Am 2019, 103: 337–350.

Article  PubMed  Google Scholar 

Cheong JLY, de Pablo-Fernandez E, Foltynie T, Noyce AJ. The association between type 2 diabetes mellitus and Parkinson’s disease. J Parkinsons Dis 2020, 10: 775–789.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Nowell J, Blunt E, Gupta D, Edison P. Antidiabetic agents as a novel treatment for Alzheimer’s and Parkinson’s disease. Ageing Res Rev 2023, 89: 101979.

Article  PubMed  CAS  Google Scholar 

Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U, Shaw JE. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract 2014, 103: 137–149.

Article  PubMed  CAS  Google Scholar 

Duarte AI, Moreira PI, Oliveira CR. Insulin in central nervous system: More than just a peripheral hormone. J Aging Res 2012, 2012: 384017.

Article  PubMed  PubMed Central  Google Scholar 

Yip CC. The insulin-binding domain of insulin receptor is encoded by exon 2 and exon 3. J Cell Biochem 1992, 48: 19–25.

Article  PubMed  CAS  Google Scholar 

Savkur RS, Philips AV, Cooper TA, Dalton JC, Moseley ML, Ranum LPW, et al. Insulin receptor splicing alteration in myotonic dystrophy type 2. Am J Hum Genet 2004, 74: 1309–1313.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Frasca F, Pandini G, Scalia P, Sciacca L, Mineo R, Costantino A, et al. Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Mol Cell Biol 1999, 19: 3278–3288.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Huang Z, Bodkin NL, Ortmeyer HK, Hansen BC, Shuldiner AR. Hyperinsulinemia is associated with altered insulin receptor mRNA splicing in muscle of the spontaneously obese diabetic rhesus monkey. J Clin Invest 1994, 94: 1289–1296.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sędzikowska A, Szablewski L. Insulin and insulin resistance in Alzheimer’s disease. Int J Mol Sci 2021, 22: 9987.

Article  PubMed  PubMed Central  Google Scholar 

Zhao X, An X, Yang C, Sun W, Ji H, Lian F. The crucial role and mechanism of insulin resistance in metabolic disease. Front Endocrinol 2023, 14: 1149239.

Article  Google Scholar 

Kellar D, Craft S. Brain insulin resistance in Alzheimer’s disease and related disorders: Mechanisms and therapeutic approaches. Lancet Neurol 2020, 19: 758–766.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Akhtar A, Sah SP. Insulin signaling pathway and related molecules: Role in neurodegeneration and Alzheimer’s disease. Neurochem Int 2020, 135: 104707.

Article  PubMed  CAS  Google Scholar 

Labandeira CM, Fraga-Bau A, Arias Ron D, Alvarez-Rodriguez E, Vicente-Alba P, Lago-Garma J, et al. Parkinson’s disease and diabetes mellitus: Common mechanisms and treatment repurposing. Neural Regen Res 2022, 17: 1652–1658.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Arnold SE, Arvanitakis Z, Macauley-Rambach SL, Koenig AM, Wang HY, Ahima RS, et al. Brain insulin resistance in type 2 diabetes and Alzheimer disease: Concepts and conundrums. Nat Rev Neurol 2018, 14: 168–181.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Huang X, Liu G, Guo J, Su Z. The PI3K/AKT pathway in obesity and type 2 diabetes. Int J Biol Sci 2018, 14: 1483–1496.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Rai SN, Dilnashin H, Birla H, Singh SS, Zahra W, Rathore AS, et al. The role of PI3K/akt and ERK in neurodegenerative disorders. Neurotox Res 2019, 35: 775–795.

Article  PubMed  CAS  Google Scholar 

Matsuda S, Ikeda Y, Murakami M, Nakagawa Y, Tsuji A, Kitagishi Y. Roles of PI3K/AKT/GSK3 pathway involved in psychiatric illnesses. Diseases 2019, 7: 22.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Shima H, Pende M, Chen Y, Fumagalli S, Thomas G, Kozma SC. Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J 1998, 17: 6649–6659.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lawlor MA, Mora A, Ashby PR, Williams MR, Murray-Tait V, Malone L, et al. Essential role of PDK1 in regulating cell size and development in mice. EMBO J 2002, 21: 3728–3738.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ramasubbu K, Devi Rajeswari V. Impairment of insulin signaling pathway PI3K/Akt/mTOR and insulin resistance induced AGEs on diabetes mellitus and neurodegenerative diseases: A perspective review. Mol Cell Biochem 2023, 478: 1307–1324.

Article  PubMed  CAS  Google Scholar 

Burke JE, Williams RL. Synergy in activating class I PI3Ks. Trends Biochem Sci 2015, 40: 88–100.

Article  PubMed  CAS  Google Scholar 

Peng Y, Wang Y, Zhou C, Mei W, Zeng C. PI3K/akt/mTOR pathway and its role in cancer therapeutics: Are we making headway? Front Oncol 2022, 12: 819128.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kim B, Feldman EL. Insulin resistance in the nervous system. Trends Endocrinol Metab 2012, 23: 133–141.

Article  PubMed  PubMed Central  CAS 

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