Leptin/LPS-treated dendritic cells reduce the expression of genes involved in tumor tissue metastasis and angiogenesis in an animal model of breast cancer

Sharifian A, Pourhoseingholi MA, Emadedin M, et al. Burden of breast cancer in Iranian women is increasing. Asian Pac J Cancer Prev. 2015;16(12):5049–52.

Article  PubMed  Google Scholar 

Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49.

Article  PubMed  Google Scholar 

Higgins MJ, Baselga J. Targeted therapies for breast cancer. J Clin Investig. 2011;121(10):3797–803.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qi C-J, Ning Y-L, Han Y-S, et al. Autologous dendritic cell vaccine for estrogen receptor (ER)/progestin receptor (PR) double-negative breast cancer. Cancer Immunol Immunother. 2012;61(9):1415–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lam Q, Lu L. Role of leptin in immunity. Cell Mol Immunol. 2007;4(1):1–13.

CAS  PubMed  Google Scholar 

Procaccini C, Jirillo E, Matarese G. Leptin as an immunomodulator. Mol Aspects Med. 2012;33(1):35–45.

Article  CAS  PubMed  Google Scholar 

Lam QLK, Zheng B-J, Jin D-Y, et al. Leptin induces CD40 expression through the activation of Akt in murine dendritic cells. J Biol Chem. 2007;282(38):27587–97.

Article  CAS  PubMed  Google Scholar 

White SJ, Taylor MJ, Hurt RT, et al. Leptin-based adjuvants: an innovative approach to improve vaccine response. Vaccine. 2013;31(13):1666–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li M, Knight DA, Snyder LA, et al. A role for CCL2 in both tumor progression and immunosurveillance. Oncoimmunology. 2013;2(7):e25474.

Article  PubMed  PubMed Central  Google Scholar 

Bonapace L, Coissieux M-M, Wyckoff J, et al. Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis. Nature. 2014;515(7525):130–3.

Article  CAS  PubMed  Google Scholar 

Velasco-Velázquez M, Xolalpa W, Pestell RG. The potential to target CCL5/CCR5 in breast cancer. Expert Opin Ther Targets. 2014;18(11):1265–75.

Article  PubMed  Google Scholar 

Aldinucci D, Casagrande N. Inhibition of the CCL5/CCR5 axis against the progression of gastric cancer. Int J Mol Sci. 2018;19(5):1477.

Article  PubMed  PubMed Central  Google Scholar 

Shibata M, Kono K, Takenoshita S. Inhibiting VEGF in cancer immunotherapy. Clinical Immunology Communications. 2022;2:12–6.

Article  CAS  Google Scholar 

Gao H, Lan X, Li S, et al. Relationships of MMP-9, E-cadherin, and VEGF expression with clinicopathological features and response to chemosensitivity in gastric cancer. Tumor Biology. 2017;39(5):1010428317698368.

Article  PubMed  Google Scholar 

Augoff K, Hryniewicz-Jankowska A, Tabola R, et al. MMP9: a tough target for targeted therapy for cancer. Cancers. 2022;14(7):1847.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hirano T, Ishihara K, Hibi M. Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene. 2000;19(21):2548–56.

Article  CAS  PubMed  Google Scholar 

Tawara K, Scott H, Emathinger J, et al. Co-expression of VEGF and IL-6 family cytokines is associated with decreased survival in HER2 negative breast cancer patients: subtype-specific IL-6 family cytokine-mediated VEGF secretion. Transl Oncol. 2019;12(2):245–55.

Article  PubMed  Google Scholar 

Jiang W, Lian J, Yue Y, et al. IL-33/ST2 as a potential target for tumor immunotherapy. Eur J Immunol. 2021;51(8):1943–55.

Article  CAS  PubMed  Google Scholar 

Wasmer M-H, Krebs P. The role of IL-33-dependent inflammation in the tumor microenvironment. Front Immunol. 2017;7:682.

Article  PubMed  PubMed Central  Google Scholar 

Yang Q, Li G, Zhu Y, et al. IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cells. Eur J Immunol. 2011;41(11):3351–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao X, Wang X, Yang Q, et al. Tumoral expression of IL-33 inhibits tumor growth and modifies the tumor microenvironment through CD8+ T and NK cells. J Immunol. 2015;194(1):438–45.

Article  CAS  PubMed  Google Scholar 

Chen J, Zhao Y, Jiang Y, et al. Interleukin-33 contributes to the induction of Th9 cells and antitumor efficacy by dectin-1-activated dendritic cells. Front Immunol. 2018;9:1787.

Article  PubMed  PubMed Central  Google Scholar 

Xu L, Zheng Y, Wang J, et al. IL33 activates CD8+ T and NK cells through MyD88 pathway to suppress the lung cancer cell growth in mice. Biotech Lett. 2020;42:1113–21.

Article  CAS  Google Scholar 

Basirjafar P, Zandvakili R, Masoumi J, et al. Leptin/lipopolysaccharide-treated dendritic cell vaccine improved cellular immune responses in an animal model of breast cancer. Immunopharmacol Immunotoxicol. 2024;46(1):73–85.

Article  CAS  PubMed  Google Scholar 

Masoumi J, Jafarzadeh A, Tavakoli T, et al. Inhibition of apelin/APJ axis enhances the potential of dendritic cell-based vaccination to modulate TH1 and TH2 cell-related immune responses in an animal model of metastatic breast cancer. Adv Med Sci. 2022;67(1):170–8.

Article  CAS  PubMed  Google Scholar 

Zandvakili R, Basirjafar P, Masoumi J, et al. Vaccination with celecoxib-treated dendritic cells improved cellular immune responses in an animal breast cancer model. Adv Med Sci. 2023;68(1):157–68.

Article  CAS  PubMed  Google Scholar 

Jadidi-Niaragh F, Atyabi F, Rastegari A, et al. CD73 specific siRNA loaded chitosan lactate nanoparticles potentiate the antitumor effect of a dendritic cell vaccine in 4T1 breast cancer bearing mice. J Control Release. 2017;246:46–59.

Article  CAS  PubMed  Google Scholar 

Mattioli B, Straface E, Quaranta MG, et al. Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming. J Immunol. 2005;174(11):6820–8.

Article  CAS  PubMed  Google Scholar 

Zhou J, Xi Y, Mu X, et al. Antitumor immunity induced by VE-cadherin modified DC vaccine. Oncotarget. 2017;8(40):67369.

Article  PubMed  PubMed Central  Google Scholar 

Zhang S-N, Choi I-K, Huang J-H, et al. Optimizing DC vaccination by combination with oncolytic adenovirus coexpressing IL-12 and GM-CSF. Mol Ther. 2011;19(8):1558–68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan Z, Huimin W, Zhong H. Metronomic chemotherapy combined with dendritic cell vaccine inhibits VEGF secretion. CJLC. 2013;16(9):460–3.

CAS  Google Scholar 

Mehner C, Hockla A, Miller E, et al. Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer. Oncotarget. 2014;5(9):2736.

Article  PubMed  PubMed Central  Google Scholar 

留言 (0)

沒有登入
gif