Jebeile H, Kelly AS, O’Malley G, et al. Obesity in children and adolescents: epidemiology, causes, assessment, and management. Lancet Diabetes Endocrinol. 2022;10:351–65. https://doi.org/10.1016/s2213-8587(22)00047-x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abdelhamed MH, Salah SKKAL, et al. Indices of insulin resistance and adiposity can detect obesity-related morbidity in pediatrics. Saudi Med J. 2022;43:161–8. https://doi.org/10.15537/smj.2022.43.2.20210720.

Article  PubMed  PubMed Central  Google Scholar 

Haddawi KH, Al-Ziaydi AG, Al-Kathem Al-Khalidi FA. The role of adipokines and ghrelin in interactions and clinical implications in childhood obesity. J Educ Health Promotion. 2024;13:40. https://doi.org/10.4103/jehp.jehp_972_23.

Article  Google Scholar 

Mainieri F, Tagi VM, Chiarelli F. Insulin resistance in children. Curr Opin Pediatr. 2022;34:400–6. https://doi.org/10.1097/mop.0000000000001151.

Article  PubMed  Google Scholar 

Fahy E, Cotter D, Sud M, et al. Lipid classification, structures and tools. Biochem Biophys Acta. 2011;1811:637–47. https://doi.org/10.1016/j.bbalip.2011.06.009.

Article  CAS  PubMed  Google Scholar 

Wang R, Li B, Lam SM, et al. Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression. J Genet Genom = Yi chuan xue bao. 2020;47:69–83. https://doi.org/10.1016/j.jgg.2019.11.009.

Article  CAS  Google Scholar 

Wu P, Wang Y, Ye Y, et al. Liver biomarkers, lipid metabolites, and risk of gestational diabetes mellitus in a prospective study among Chinese pregnant women. BMC Med. 2023;21:150. https://doi.org/10.1186/s12916-023-02818-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee S, Norheim F, Gulseth HL, et al. Skeletal muscle phosphatidylcholine and phosphatidylethanolamine respond to exercise and influence insulin sensitivity in men. Sci Rep. 2018;8:6531. https://doi.org/10.1038/s41598-018-24976-x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kumar A, Sundaram K, Mu J, et al. High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance. Nat Commun. 2021;12:213. https://doi.org/10.1038/s41467-020-20500-w.

Article  CAS  PubMed  PubMed Central  Google Scholar 

van der Veen JN, Lingrell S, McCloskey N, et al. A role for phosphatidylcholine and phosphatidylethanolamine in hepatic insulin signaling. FASEB J: Publ Federation Am Soc Experiment Biol. 2019;33:5045–57. https://doi.org/10.1096/fj.201802117R.

Article  Google Scholar 

van Dierendonck X, Vrieling F, Smeehuijzen L, et al. Triglyceride breakdown from lipid droplets regulates the inflammatory response in macrophages. Proc Natl Acad Sci USA. 2022;119:e2114739119. https://doi.org/10.1073/pnas.2114739119.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Du M, Gan Y, et al. Triglyceride induced metabolic inflammation: potential connection of insulin resistance and recurrent pregnancy loss. Front Endocrinol. 2021;12:621845. https://doi.org/10.3389/fendo.2021.621845.

Article  Google Scholar 

Elhady M, Elazab A, Bahagat KA, et al. Fatty pancreas in relation to insulin resistance and metabolic syndrome in children with obesity. J Pediat Endocrinol Metabolism : JPEM. 2019;32:19–26. https://doi.org/10.1515/jpem-2018-0315.

Article  CAS  Google Scholar 

Tatsuta T, Langer T. Intramitochondrial phospholipid trafficking. Biochimica et Biophys Acta. Mol Cell Biol Lipids. 2017;1862:81–9. https://doi.org/10.1016/j.bbalip.2016.08.006.

Article  CAS  Google Scholar 

Patel D, Witt SN. Ethanolamine and phosphatidylethanolamine: partners in health and disease. Oxid Med Cell Longev. 2017;2017:4829180. https://doi.org/10.1155/2017/4829180.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Coleman L, Coleman J. The measurement of puberty: a review. J Adolesc. 2002;25:535–50. https://doi.org/10.1006/jado.2002.0494.

Article  PubMed  Google Scholar 

Keskin M, Kurtoglu S, Kendirci M, et al. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics. 2005;115:e500-503. https://doi.org/10.1542/peds.2004-1921.

Article  PubMed  Google Scholar 

Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents (2011) Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report. Pediatrics 128(Supplement_5), S213-S256. https://doi.org/10.1542/peds.2009-2107C

Pang Z, Chong J, Zhou G, et al. MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights. Nucleic Acids Res. 2021;49:W388-w396. https://doi.org/10.1093/nar/gkab382.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang Q, Vijayakumar A, Kahn BB. Metabolites as regulators of insulin sensitivity and metabolism. Nat Rev Mol Cell Biol. 2018;19:654–72. https://doi.org/10.1038/s41580-018-0044-8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu ZR, Du HW, Cui LW, et al. Association of β-cell function and insulin resistance with pediatric type 2 diabetes among Chinese children. World J Diabetes. 2021;12:1292–303. https://doi.org/10.4239/wjd.v12.i8.1292.

Article  PubMed  PubMed Central  Google Scholar 

Genoni G, Menegon V, Secco GG, et al. Insulin resistance, serum uric acid and metabolic syndrome are linked to cardiovascular dysfunction in pediatric obesity. Int J Cardiol. 2017;249:366–71. https://doi.org/10.1016/j.ijcard.2017.09.031.

Article  PubMed  Google Scholar 

Chang W, Hatch GM, Wang Y, et al. The relationship between phospholipids and insulin resistance: from clinical to experimental studies. J Cell Mol Med. 2019;23:702–10. https://doi.org/10.1111/jcmm.13984.

Article  PubMed  Google Scholar 

Pang SJ, Liu TT, Pan JC, et al. The association between the plasma phospholipid profile and insulin resistance: a population-based cross-section study from the China adult chronic disease and nutrition surveillance. Nutrients. 2024;16. https://doi.org/10.3390/nu16081205.

Winter PW, Van Orden AK, Roess DA, et al. Actin-dependent clustering of insulin receptors in membrane microdomains. Biochem Biophys Acta. 2012;1818:467–73. https://doi.org/10.1016/j.bbamem.2011.10.006.

Article  CAS  PubMed  Google Scholar 

Pilon M. Revisiting the membrane-centric view of diabetes. Lipids Health Dis. 2016;15:167. https://doi.org/10.1186/s12944-016-0342-0.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Levental KR, Malmberg E, Symons JL, et al. Lipidomic and biophysical homeostasis of mammalian membranes counteracts dietary lipid perturbations to maintain cellular fitness. Nat Commun. 2020;11:1339. https://doi.org/10.1038/s41467-020-15203-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Krц╤ger J, Jacobs S, Jansen EH, et al. Erythrocyte membrane fatty acid fluidity and risk of type 2 diabetes in the EPIC-Potsdam study. Diabetologia. 2015; 58: 282–289. https://doi.org/10.1007/s00125-014-3421-7

Tian Y, Mehta K, Jellinek MJ, et al. Hepatic phospholipid remodeling modulates insulin sensitivity and systemic metabolism. Adv Sci (Weinheim, Baden-Wurttemberg, Germany). 2023;10:e2300416. https://doi.org/10.1002/advs.202300416.

Article  CAS  Google Scholar 

Funai K, Lodhi IJ, Spears LD, et al. Skeletal muscle phospholipid metabolism regulates insulin sensitivity and contractile function. Diabetes. 2016;65:358–70. https://doi.org/10.2337/db15-0659.

Article  CAS  PubMed  Google Scholar 

Younsi M, Quilliot D, Al-Makdissy N, et al. Erythrocyte membrane phospholipid composition is related to hyperinsulinemia in obese nondiabetic women: effects of weight loss. Metabolism: Clin Experimental. 2002;51:1261–8. https://doi.org/10.1053/meta.2002.35184.

Article  CAS  Google Scholar 

Newsom SA, Brozinick J