Liu Z, Mahale P, Engels EA. Sepsis and risk of cancer among elderly adults in the United States. Clin Infect Dis. 2019;68(5):717–24. https://doi.org/10.1093/cid/ciy530.

Article  CAS  PubMed  Google Scholar 

Mirouse A, Vigneron C, Llitjos JF, Chiche JD, Mira JP, Mokart D, et al. Sepsis and cancer: an interplay of friends and foes. Am J Respir Crit Care Med. 2020;202(12):1625–35. https://doi.org/10.1164/rccm.202004-1116TR.

Article  PubMed  Google Scholar 

Vigneron C, Mirouse A, Merdji H, Rousseau C, Cousin C, Alby-Laurent F, et al. Sepsis inhibits tumor growth in mice with cancer through Toll-like receptor 4-associated enhanced natural killer cell activity. Oncoimmunology. 2019;8(11): e1641391. https://doi.org/10.1080/2162402x.2019.1641391.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Danahy DB, Jensen IJ, Griffith TS, Badovinac VP. Cutting edge: polymicrobial sepsis has the capacity to reinvigorate tumor-infiltrating CD8 T cells and prolong host survival. J Immunol. 2019;202(10):2843–8. https://doi.org/10.4049/jimmunol.1900076.

Article  CAS  PubMed  Google Scholar 

Buzás K, Marton A, Vizler C, Gyukity-Sebestyén E, Harmati M, Nagy K, et al. Bacterial sepsis increases survival in metastatic melanoma: chlamydophila pneumoniae induces macrophage polarization and tumor regression. J Invest Dermatol. 2016;136(4):862–5. https://doi.org/10.1016/j.jid.2015.12.032.

Article  CAS  PubMed  Google Scholar 

Hensley MK, Donnelly JP, Carlton EF, Prescott HC. Epidemiology and outcomes of cancer-related versus non-cancer-related sepsis hospitalizations. Crit Care Med. 2019;47(10):1310–6. https://doi.org/10.1097/ccm.0000000000003896.

Article  PubMed  PubMed Central  Google Scholar 

Mendonça MA, Cunha FQ, Murta EF, Tavares-Murta BM. Failure of neutrophil chemotactic function in breast cancer patients treated with chemotherapy. Cancer Chemother Pharmacol. 2006;57(5):663–70. https://doi.org/10.1007/s00280-005-0086-4.

Article  CAS  PubMed  Google Scholar 

Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science. 2011;331(6024):1565–70. https://doi.org/10.1126/science.1203486.

Article  CAS  PubMed  Google Scholar 

Camou F, Didier M, Leguay T, Milpied N, Daste A, Ravaud A, et al. Long-term prognosis of septic shock in cancer patients. Support Care Cancer. 2020;28(3):1325–33. https://doi.org/10.1007/s00520-019-04937-4.

Article  PubMed  Google Scholar 

Vincent JL. Current sepsis therapeutics. EBioMedicine. 2022;86: 104318. https://doi.org/10.1016/j.ebiom.2022.104318.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Giudice A, Aliberti SM, Barbieri A, Pentangelo P, Bisogno I, D’Arena G, et al. Potential mechanisms by which glucocorticoids induce breast carcinogenesis through Nrf2 inhibition. Front Biosci. 2022;27(7):223. https://doi.org/10.31083/j.fbl2707223.

Article  CAS  Google Scholar 

Dietrich K, Schned A, Fortuny J, Heaney J, Marsit C, Kelsey KT, et al. Glucocorticoid therapy and risk of bladder cancer. Br J Cancer. 2009;101(8):1316–20. https://doi.org/10.1038/sj.bjc.6605314.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Phares TW, Kotraiah V, Chung CS, Unsinger J, Mazer M, Remy KE, et al. A peptide-based checkpoint immunomodulator alleviates immune dysfunction in murine polymicrobial sepsis. Shock. 2021;55(6):806–15. https://doi.org/10.1097/shk.0000000000001682.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shindo Y, McDonough JS, Chang KC, Ramachandra M, Sasikumar PG, Hotchkiss RS. Anti-PD-L1 peptide improves survival in sepsis. J Surg Res. 2017;208:33–9. https://doi.org/10.1016/j.jss.2016.08.099.

Article  CAS  PubMed  Google Scholar 

Huang X, Venet F, Wang YL, Lepape A, Yuan Z, Chen Y, et al. PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis. Proc Natl Acad Sci USA. 2009;106(15):6303–8. https://doi.org/10.1073/pnas.0809422106.

Article  PubMed  PubMed Central  Google Scholar 

Hotchkiss RS, Colston E, Yende S, Angus DC, Moldawer LL, Crouser ED, et al. Immune checkpoint inhibition in sepsis: a phase 1b randomized, placebo-controlled, single ascending dose study of antiprogrammed cell death-ligand 1 antibody (BMS-936559). Crit Care Med. 2019;47(5):632–42. https://doi.org/10.1097/ccm.0000000000003685.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hotchkiss RS, Colston E, Yende S, Crouser ED, Martin GS, Albertson T, et al. Immune checkpoint inhibition in sepsis: a phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab. Intensive Care Med. 2019;45(10):1360–71. https://doi.org/10.1007/s00134-019-05704-z.

Article  CAS  PubMed  PubMed Central  Google Scholar 

He J, Qin W, Jiang S, Lin Y, Lin Y, Yang R, et al. Oxymatrine attenuates sepsis-induced inflammation and organ injury via inhibition of HMGB1/RAGE/NF-κB signaling pathway. Drug Dev Res. 2024;85(4): e22219. https://doi.org/10.1002/ddr.22219.

Article  CAS  PubMed  Google Scholar 

Chen MH, Gu YY, Zhang AL, Sze DM, Mo SL, May BH. Biological effects and mechanisms of matrine and other constituents of Sophora flavescens in colorectal cancer. Pharmacol Res. 2021;171: 105778. https://doi.org/10.1016/j.phrs.2021.105778.

Article  CAS  PubMed  Google Scholar 

Li ST, Dai Q, Zhang SX, Liu YJ, Yu QQ, Tan F, et al. Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway. Acta Pharmacol Sin. 2018;39(8):1294–304. https://doi.org/10.1038/aps.2017.143.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang H, Sun X, Gao F, Zhong B, Zhang YH, Sun Z. Effect of ulinastatin on growth inhibition, apoptosis of breast carcinoma cells is related to a decrease in signal conduction of JNk-2 and NF-κB. J Exp Clin Cancer Res. 2012;31(1):2. https://doi.org/10.1186/1756-9966-31-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu J, Peng Y, Yang M, Guo N, Liu H, Gao H, et al. Increased levels of myeloid-derived suppressor cells in esophageal cancer patients is associated with the complication of sepsis. Biomed Pharmacother. 2020;125: 109864. https://doi.org/10.1016/j.biopha.2020.109864.

Article  CAS  PubMed  Google Scholar 

Liu MA, Bakow BR, Hsu TC, Chen JY, Su KY, Asiedu EK, et al. Temporal trends in sepsis incidence and mortality in patients with cancer in the US population. Am J Crit Care. 2021;30(4):e71–9. https://doi.org/10.4037/ajcc2021632.

Article  PubMed  Google Scholar 

Martín-Fernández M, Tamayo-Velasco Á, Aller R, Gonzalo-Benito H, Martínez-Paz P, Tamayo E. Endothelial dysfunction and neutrophil degranulation as central events in sepsis physiopathology. Int J Mol Sci. 2021;22(12):6272. https://doi.org/10.3390/ijms22126272.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dunzendorfer S, Schratzberger P, Reinisch N, Kähler CM, Wiedermann CJ. Pentoxifylline differentially regulates migration and respiratory burst activity of the neutrophil. Ann N Y Acad Sci. 1997;832:330–40. https://doi.org/10.1111/j.1749-6632.1997.tb46261.x.

Article  CAS  PubMed  Google Scholar 

Bone RC. Inhibitors of complement and neutrophils: a critical evaluation of their role in the treatment of sepsis. Crit Care Med. 1992;20(6):891–8.

Article  CAS  PubMed  Google Scholar 

Hua Y, Liu D, Zhang D, Wang X, Wei Q, Qin W. Extracellular AMP suppresses endotoxemia-induced inflammation by alleviating neutrophil activation. Front Immunol. 2020;11:1220. https://doi.org/10.3389/fimmu.2020.01220.