Netea, M. G. et al. Trained immunity: a program of innate immune memory in health and disease. Science 352, aaf1098 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Quintin, J. et al. Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes. Cell Host Microbe 12, 223–232 (2012).

Article  CAS  PubMed  Google Scholar 

Mitroulis, I. et al. Modulation of myelopoiesis progenitors is an integral component of trained immunity. Cell 172, 147–161 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie, X. et al. Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection. Nat. Immunol. 21, 1119–1133 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Muench, D. E. et al. Mouse models of neutropenia reveal progenitor-stage-specific defects. Nature 582, 109–114 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Das, S. et al. Neutrophils and galectin-3 defend mice from lethal bacterial infection and humans from acute respiratory failure. Nat. Commun. 15, 4724 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khoyratty, T. E. et al. Distinct transcription factor networks control neutrophil-driven inflammation. Nat. Immunol. 22, 1093–1106 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Filippo, K. & Rankin, S. M. The secretive life of neutrophils revealed by intravital microscopy. Front. Cell Dev. Biol. 8, 603230 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Liew, P. X. & Kubes, P. The neutrophil’s role during health and disease. Physiol. Rev. 99, 1223–1248 (2019).

Article  CAS  PubMed  Google Scholar 

Furze, R. C. & Rankin, S. M. The role of the bone marrow in neutrophil clearance under homeostatic conditions in the mouse. FASEB J. 22, 3111–3119 (2008).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Giladi, A. et al. Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis. Nat. Cell Biol. 20, 836–846 (2018).

Article  CAS  PubMed  Google Scholar 

Mitroulis, I. et al. Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche. J. Clin. Invest. 127, 3624–3639 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Evrard, M. et al. Developmental analysis of bone marrow neutrophils reveals populations specialized in expansion, trafficking, and effector functions. Immunity 48, 364–379 (2018).

Article  CAS  PubMed  Google Scholar 

Paul, F. et al. Transcriptional heterogeneity and lineage commitment in myeloid progenitors. Cell 163, 1663–1677 (2015).

Article  CAS  PubMed  Google Scholar 

Zhang, D. E. et al. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice. Proc. Natl Acad. Sci. USA 94, 569–574 (1997).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hirai, H. et al. C/EBPβ is required for ‘emergency’ granulopoiesis. Nat. Immunol. 7, 732–739 (2006).

Article  CAS  PubMed  Google Scholar 

Zhang, H. et al. STAT3 controls myeloid progenitor growth during emergency granulopoiesis. Blood 116, 2462–2471 (2010).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dakic, A. et al. PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. J. Exp. Med. 201, 1487–1502 (2005).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Crispino, J. D. & Horwitz, M. S. GATA factor mutations in hematologic disease. Blood 129, 2103–2110 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hollanda, L. M. et al. An inherited mutation leading to production of only the short isoform of GATA-1 is associated with impaired erythropoiesis. Nat. Genet. 38, 807–812 (2006).

Article  CAS  PubMed  Google Scholar 

Camargo, R., Sahoo, S. S., Cordoba, J. C. & Magalhaes, I. Q. Germline GATA1 exon 2 mutation associated with chronic cytopenia and a non-down syndrome transient abnormal myelopoiesis with clonal trisomy 21. Leukemia 36, 2347–2350 (2022).

Article  CAS  PubMed  Google Scholar 

Harper, T. C. et al. GATA1 deletion in human pluripotent stem cells increases differentiation yield and maturity of neutrophils. iScience 26, 107804 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dejas, L., Santoni, K., Meunier, E. & Lamkanfi, M. Regulated cell death in neutrophils: from apoptosis to NETosis and pyroptosis. Semin. Immunol. 70, 101849 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tu, H. et al. Dying to defend: neutrophil death pathways and their implications in immunity. Adv. Sci. 11, e2306457 (2024).

Article  Google Scholar 

Lawrence, S. M., Corriden, R. & Nizet, V. How neutrophils meet their end. Trends Immunol. 41, 531–544 (2020).

Article  CAS  PubMed  Google Scholar 

Ma, F. et al. Gasdermin E dictates inflammatory responses by controlling the mode of neutrophil death. Nat. Commun. 15, 386 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, J. et al. Visualizing the function and fate of neutrophils in sterile injury and repair. Science 358, 111–116 (2017).

Article  CAS  PubMed  Google Scholar 

Mukhopadhyay, A. et al. trans-Endothelial neutrophil migration activates bactericidal function via Piezo1 mechanosensing. Immunity 57, 52–67 (2024).

Article  CAS  PubMed  Google Scholar 

Zhang, N. et al. Cell surface RNAs control neutrophil recruitment. Cell 187, 846–860 (2024).

Article  CAS  PubMed  Google Scholar 

Lou, O., Alcaide, P., Luscinskas, F. W. & Muller, W. A. CD99 is a key mediator of the transendothelial migration of neutrophils. J. Immunol. 178, 1136–1143 (2007).

Article  CAS  PubMed  Google Scholar 

Sullivan, D. P., Watson, R. L. & Muller, W. A. 4D intravital microscopy uncovers critical strain differences for the roles of PECAM and CD99 in leukocyte diapedesis. Am. J. Physiol. Heart Circ. Physiol. 311, H621–H632 (2016).

Article  PubMed