Bioinformatics combined with network pharmacology and experimental validation to identify key biomarkers of hepatocellular carcinoma and corresponding compounds in Radix Astragali and Pueraria Mirifica

Arneth B (2019) Tumor microenvironment. Medicina (Kaunas) 56(1):15

Article  PubMed  Google Scholar 

Dong X, Wang F, Liu C, Ling J, Jia X, Shen F, Yang N, Zhu S, Zhong L, Li Q (2021a) Single-cell analysis reveals the intra-tumor heterogeneity and identifies MLXIPL as a biomarker in the cellular trajectory of hepatocellular carcinoma. Cell Death Discov 7:14

Article  PubMed  PubMed Central  Google Scholar 

Dong Y, Zhao Q, Wang Y (2021b) Network pharmacology-based investigation of potential targets of astragalus membranaceous-angelica sinensis compound acting on diabetic nephropathy. Sci Rep 11:19496

Article  PubMed  PubMed Central  Google Scholar 

Fattovich G, Stroffolini T, Zagni I, Donato F (2004) Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology 127:S35-50

Article  PubMed  Google Scholar 

Gao S, Zhu D, Zhu J, Shen L, Zhu M, Ren X (2021a) Screening hub genes of hepatocellular carcinoma based on public databases. Comput Math Methods Med 2021:7029130

Article  PubMed  PubMed Central  Google Scholar 

Gao ST, Girma DD, Bionaz M, Ma L, Bu DP (2021b) Hepatic transcriptomic adaptation from prepartum to postpartum in dairy cows. J Dairy Sci 104:1053–1072

Article  PubMed  Google Scholar 

Gaudreault F, Najmanovich RJ (2015) FlexAID: revisiting docking on non-native-complex structures. J Chem Inf Model 55:1323–1336

Article  PubMed  Google Scholar 

Haque A, Sahu V, Lombardo JL, Xiao L, George B, Wolff RA, Morris JS, Rashid A, Kopchick JJ, Kaseb AO, Amin HM (2022) Disruption of growth hormone receptor signaling abrogates hepatocellular carcinoma development. J Hepatocell Carcinoma 9:823–837

Article  PubMed  PubMed Central  Google Scholar 

Hin Tang JJ, HaoThng DK, Lim JJ, Toh TB (2020) JAK/STAT signaling in hepatocellular carcinoma. Hepat Oncol 7:Hep18

Article  PubMed  PubMed Central  Google Scholar 

Jin J, Chen B, Zhan X, Zhou Z, Liu H, Dong Y (2021) Network pharmacology and molecular docking study on the mechanism of colorectal cancer treatment using Xiao-Chai-Hu-Tang. PLoS ONE 16:e0252508

Article  PubMed  PubMed Central  Google Scholar 

Khalaf K, Hana D, Chou JT, Singh C, Mackiewicz A, Kaczmarek M (2021) Aspects of the tumor microenvironment involved in immune resistance and drug resistance. Front Immunol 12:656364

Article  PubMed  PubMed Central  Google Scholar 

Kim S (2021) Exploring chemical information in PubChem. Curr Protoc 1:e217

Article  PubMed  PubMed Central  Google Scholar 

Koumbi L (2017) Dietary factors can protect against liver cancer development. World J Hepatol 9:119–125

Article  PubMed  PubMed Central  Google Scholar 

Lai GH, Wang F, Nie DR, Lei SJ, Wu ZJ, Cao JX, Tang LL (2022) Correlation of glucose metabolism with cancer and intervention with traditional Chinese medicine. Evid Based Complement Alternat Med 2022:2192654

Article  PubMed  PubMed Central  Google Scholar 

Li LK, Kuang WJ, Huang YF, Xie HH, Chen G, Zhou QC, Wang BR, Wan LH (2012) Anti-tumor effects of Astragalus on hepatocellular carcinoma in vivo. Indian J Pharmacol 44:78–81

Article  PubMed  PubMed Central  Google Scholar 

Li S, Hao L, Hu X, Li L (2023) A systematic study on the treatment of hepatitis B-related hepatocellular carcinoma with drugs based on bioinformatics and key target reverse network pharmacology and experimental verification. Infect Agent Cancer 18:41

Article  PubMed  PubMed Central  Google Scholar 

Liu X, Li T, Kong D, You H, Kong F, Tang R (2020) Prognostic implications of alcohol dehydrogenases in hepatocellular carcinoma. BMC Cancer 20:1204

Article  PubMed  PubMed Central  Google Scholar 

Liu H, Li X, Duan Y, Xie JB, Piao XL (2021a) Mechanism of gypenosides of Gynostemma pentaphyllum inducing apoptosis of renal cell carcinoma by PI3K/AKT/mTOR pathway. J Ethnopharmacol 271:113907

Article  PubMed  Google Scholar 

Liu J, Liu J, Tong X, Peng W, Wei S, Sun T, Wang Y, Zhang B, Li W (2021b) Network pharmacology prediction and molecular docking-based strategy to discover the potential pharmacological mechanism of Huai Hua San against ulcerative colitis. Drug Des Devel Ther 15:3255–3276

Article  PubMed  PubMed Central  Google Scholar 

Liu Z, Ma H, Lai Z (2021c) Revealing the potential mechanism of Astragalus membranaceus improving prognosis of hepatocellular carcinoma by combining transcriptomics and network pharmacology. BMC Complement Med Ther 21:263

Article  PubMed  PubMed Central  Google Scholar 

Liu H, Zhao H, Sun Y (2022) Tumor microenvironment and cellular senescence: understanding therapeutic resistance and harnessing strategies. Semin Cancer Biol 86:769–781

Article  PubMed  Google Scholar 

Liu Z, Tan X, Peng L, Gao W, Zeng P (2024) Hederagenin induces apoptosis of human hepatoma HepG2 Cells via the mitochondrial pathway. Comb Chem High Throughput Screen 27:1495–1503

Article  PubMed  Google Scholar 

Ma APY, Yeung CLS, Tey SK, Mao X, Wong SWK, Ng TH, Ko FCF, Kwong EML, Tang AHN, Ng IO, Cai SH, Yun JP, Yam JWP (2021) Suppression of ACADM-mediated fatty acid oxidation promotes hepatocellular carcinoma via aberrant CAV1/SREBP1 signaling. Cancer Res 81:3679–3692

Article  PubMed  Google Scholar 

Min Z, Yuan Z, Ye C, Nan XU, Wei-Bing LI, Cheng-Yu WU, Yan C (2020) Molecular mechanism of Puerariae Lobatae Radix in treatment of hepatocellular carcinoma based on network pharmacology. Zhongguo Zhong Yao Za Zhi 45:4089–4098

PubMed  Google Scholar 

Mohamed YI, Duda DG, Awiwi MO, Lee SS, Altameemi L, Xiao L, Morris JS, Wolff RA, Elsayes KM, Hatia RI, Qayyum A, Chamseddine SM, Rashid A, Yao JC, Mahvash A, Hassan MM, Amin HM, Kaseb AO (2022) Plasma growth hormone is a potential biomarker of response to atezolizumab and bevacizumab in advanced hepatocellular carcinoma patients. Oncotarget 13:1314–1321

Article  PubMed  PubMed Central  Google Scholar 

Qi D, Chen K (2021) Bioinformatics analysis of potential biomarkers and pathway identification for major depressive disorder. Comput Math Methods Med 2021:3036741

Article  PubMed  PubMed Central  Google Scholar 

Qin S, Bi F, Gu S, Bai Y, Chen Z, Wang Z, Ying J, Lu Y, Meng Z, Pan H, Yang P, Zhang H, Chen X, Xu A, Cui C, Zhu B, Wu J, Xin X, Wang J, Shan J, Chen J, Zheng Z, Xu L, Wen X, You Z, Ren Z, Liu X, Qiu M, Wu L, Chen F (2021) Donafenib versus sorafenib in first-line treatment of unresectable or metastatic hepatocellular carcinoma: a randomized, open-label, parallel-controlled phase II-III trial. J Clin Oncol 39:3002–3011

Article  PubMed  PubMed Central  Google Scholar 

Shih S, Huang YT, Yang HI (2018) A multiple mediator analysis approach to quantify the effects of the ADH1B and ALDH2 genes on hepatocellular carcinoma risk. Genet Epidemiol 42:394–404

Article  PubMed  PubMed Central  Google Scholar 

Shimokawa M, Yoshizumi T, Itoh S, Iseda N, Sakata K, Yugawa K, Toshima T, Harada N, Ikegami T, Mori M (2020) Modulation of Nqo1 activity intercepts anoikis resistance and reduces metastatic potential of hepatocellular carcinoma. Cancer Sci 111:1228–1240

Article  PubMed  PubMed Central  Google Scholar 

Sun G, Li X, Wei J, Zhang T, Li B, Chen M, Wang Y, Chen K, Li Y (2021) Pharmacodynamic substances in Salvia miltiorrhiza for prevention and treatment of hyperlipidemia and coronary heart disease based on lipidomics technology and network pharmacology analysis. Biomed Pharmacother 141:111846

Article  PubMed  Google Scholar 

Tu S, Zhang H, Yang X, Wen W, Song K, Yu X, Qu X (2021) Screening of cervical cancer-related hub genes based on comprehensive bioinformatics analysis. Cancer Biomark 32:303–315

Article  PubMed  Google Scholar 

Wang S, Long S, Deng Z, Wu W (2020) Positive role of Chinese herbal medicine in cancer immune regulation. Am J Chin Med 48:1577–1592

Article  PubMed 

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