SPOP-mediated RIPK3 destabilization desensitizes LPS/sMAC/zVAD-induced necroptotic cell death

Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G (2010) Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol 11:700–714. https://doi.org/10.1038/nrm2970

Article  CAS  PubMed  Google Scholar 

Zhang YY, Liu H (2013) Connections between various trigger factors and the RIP1/ RIP3 signaling pathway involved in necroptosis. Asian Pac J Cancer Prev 14:7069–7074. https://doi.org/10.7314/apjcp.2013.14.12.7069

Article  PubMed  Google Scholar 

Christofferson DE, Yuan J (2010) Necroptosis as an alternative form of programmed cell death. Curr Opin Cell Biol 22:263–268. https://doi.org/10.1016/j.ceb.2009.12.003

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Liu T, Lei T, Zhang D, Du S, Girani L, Qi D, Lin C, Tong R, Wang Y (2019) RIP1/RIP3-regulated necroptosis as a target for multifaceted disease therapy (review). Int J Mol Med 44:771–786. https://doi.org/10.3892/ijmm.2019.4244

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cho YS, Challa S, Moquin D, Genga R, Ray TD, Guildford M, Chan FK (2009) Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 137:1112–1123. https://doi.org/10.1016/j.cell.2009.05.037

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou W, Yuan J (2014) Necroptosis in health and diseases. Semin Cell Dev Biol 35:14–23. https://doi.org/10.1016/j.semcdb.2014.07.013

Article  CAS  PubMed  Google Scholar 

Cunningham D, Atkin W, Lenz HJ, Lynch HT, Minsky B, Nordlinger B, Starling N (2010) Colorectal cancer. Lancet 375:1030–1047. https://doi.org/10.1016/S0140-6736(10)60353-4

Article  PubMed  Google Scholar 

Zeng F, Chen X, Cui W, Wen W, Lu F, Sun X, Ma D, Yuan Y, Li Z, Hou N, Zhao H, Bi X, Zhao J, Zhou J, Zhang Y, Xiao RP, Cai J, Zhang X (2018) RIPK1 binds MCU to mediate induction of mitochondrial ca(2+) uptake and promotes colorectal oncogenesis. Cancer Res 78:2876–2885. https://doi.org/10.1158/0008-5472.CAN-17-3082

Article  CAS  PubMed  Google Scholar 

Moriwaki K, Bertin J, Gough PJ, Orlowski GM, Chan FK (2015) Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death. Cell Death Dis 6:e1636. https://doi.org/10.1038/cddis.2015.16

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feng X, Song Q, Yu A, Tang H, Peng Z, Wang X (2015) Receptor-interacting protein kinase 3 is a predictor of survival and plays a tumor suppressive role in colorectal cancer. Neoplasma 62:592–601. https://doi.org/10.4149/neo_2015_071

Article  CAS  PubMed  Google Scholar 

Bozec D, Iuga AC, Roda G, Dahan S, Yeretssian G (2016) Critical function of the necroptosis adaptor RIPK3 in protecting from intestinal tumorigenesis. Oncotarget 7:46384–46400. https://doi.org/10.18632/oncotarget.10135

Article  PubMed  PubMed Central  Google Scholar 

Sun Y, Zhai L, Ma S, Zhang C, Zhao L, Li N, Xu Y, Zhang T, Guo Z, Zhang H, Xu P, Zhao X (2018) Down-regulation of RIP3 potentiates cisplatin chemoresistance by triggering HSP90-ERK pathway mediated DNA repair in esophageal squamous cell carcinoma. Cancer Lett 418:97–108. https://doi.org/10.1016/j.canlet.2018.01.022

Article  CAS  PubMed  Google Scholar 

An HJ, Lee CJ, Lee GE, Choi Y, Jeung D, Chen W, Lee HS, Kang HC, Lee JY, Kim DJ, Choi JS, Cho ES, Choi JS, Cho YY (2022) FBXW7-mediated ERK3 degradation regulates the proliferation of lung cancer cells. Exp Mol Med 54:35–46. https://doi.org/10.1038/s12276-021-00721-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Conev NV, Dimitrova EG, Bogdanova MK, Kashlov YK, Chaushev BG, Radanova MA, Petrov DP, Georgiev KD, Bachvarov CH, Todorov GN, Kalchev KP, Popov HB, Manev RR, Donev IS (2019) RIPK3 expression as a potential predictive and prognostic marker in metastatic colon cancer. Clin Invest Med 42:E31–E38. https://doi.org/10.25011/cim.v42i1.32390

Article  CAS  PubMed  Google Scholar 

He GW, Gunther C, Thonn V, Yu YQ, Martini E, Buchen B, Neurath MF, Sturzl M, Becker C (2017) Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice. J Exp Med 214:1655–1662. https://doi.org/10.1084/jem.20160442

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cho YY (2017) RSK2 and its binding partners in cell proliferation, transformation and cancer development. Arch Pharm Res 40:291–303. https://doi.org/10.1007/s12272-016-0880-z

Article  CAS  PubMed  Google Scholar 

Liu ZY, Zheng M, Li YM, Fan XY, Wang JC, Li ZC, Yang HJ, Yu JM, Cui J, Jiang JL, Tang J, Chen ZN (2019) RIP3 promotes colitis-associated colorectal cancer by controlling tumor cell proliferation and CXCL1-induced immune suppression. Theranostics 9:3659–3673. https://doi.org/10.7150/thno.32126

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi SW, Park HH, Kim S, Chung JM, Noh HJ, Kim SK, Song HK, Lee CW, Morgan MJ, Kang HC, Kim YS (2018) PELI1 selectively targets kinase-active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation. Mol Cell 70:920–935e927. https://doi.org/10.1016/j.molcel.2018.05.016

Article  PubMed  Google Scholar 

Mei P, Xie F, Pan J, Wang S, Gao W, Ge R, Gao B, Gao S, Chen X, Wang Y, Wu J, Ding C, Li J (2021) E3 ligase TRIM25 ubiquitinates RIP3 to inhibit TNF induced cell necrosis. Cell Death Differ 28:2888–2899. https://doi.org/10.1038/s41418-021-00790-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sanchez-Aparicio MT, Ayllon J, Leo-Macias A, Wolff T, Garcia-Sastre A (2017) Subcellular localizations of RIG-I, TRIM25, and MAVS complexes. J Virol 91. https://doi.org/10.1128/JVI.01155-16

Li M, Feng S, Wu M (2008) Multiple roles for nuclear localization signal (NLS, aa 442–472) of receptor interacting protein 3 (RIP3). Biochem Biophys Res Commun 372:850–855. https://doi.org/10.1016/j.bbrc.2008.05.144

Article  CAS  PubMed  Google Scholar 

Yoon S, Bogdanov K, Kovalenko A, Wallach D (2016) Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it. Cell Death Differ 23:253–260. https://doi.org/10.1038/cdd.2015.92

Article  CAS  PubMed  Google Scholar 

Clark A, Burleson M (2020) SPOP and cancer: a systematic review. Am J Cancer Res 10:704–726

CAS  PubMed  PubMed Central  Google Scholar 

Xu J, Wang F, Jiang H, Jiang Y, Chen J, Qin J (2015) Properties and Clinical Relevance of Speckle-Type POZ protein in human colorectal Cancer. J Gastrointest Surg 19:1484–1496. https://doi.org/10.1007/s11605-015-2767-6

Article  PubMed  Google Scholar 

Kim MS, Je EM, Oh JE, Yoo NJ, Lee SH (2013) Mutational and expressional analyses of SPOP, a candidate tumor suppressor gene, in prostate, gastric and colorectal cancers. APMIS 121:626–633. https://doi.org/10.1111/apm.12030

Article  CAS  PubMed  Google Scholar 

Zhi X, Tao J, Zhang L, Tao R, Ma L, Qin J (2016) Silencing speckle-type POZ protein by promoter hypermethylation decreases cell apoptosis through upregulating hedgehog signaling pathway in colorectal cancer. Cell Death Dis 7:e2569. https://doi.org/10.1038/cddis.2016.435

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang LQ, Yu P, Li B, Guo YH, Liang ZR, Zheng LL, Yang JH, Xu H, Liu S, Zheng LS, Zhou H, Qu LH (2018) miR-372 and miR-373 enhance the stemness of colorectal cancer cells by repressing differentiation signaling pathways. Mol Oncol 12:1949–1964. https://doi.org/10.1002/1878-0261.12376

Article  CAS  PubMed  PubMed Central 

留言 (0)

沒有登入
gif