Jain, A., Hakim, S. & Woolf, C. J. Immune drivers of physiological and pathological pain. J. Exp. Med. 221, e20221687 (2024).
Article PubMed PubMed Central CAS Google Scholar
Marchand, F., Perretti, M. & McMahon, S. B. Role of the immune system in chronic pain. Nat. Rev. Neurosci. 6, 521–532 (2005).
Article PubMed CAS Google Scholar
Yang, J. X. et al. Potential neuroimmune interaction in chronic pain: a review on immune cells in peripheral and central sensitization. Front. Pain. Res. 3, 946846 (2022).
Talbot, S., Foster, S. L. & Woolf, C. J. Neuroimmunity: physiology and pathology. Annu. Rev. Immunol. https://doi.org/10.1146/annurev-immunol-041015-055340 (2016).
Decosterd, I. & Woolf, C. J. Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain 87, 149–158 (2000).
Alvarez, P., Bogen, O., Green, P. G. & Levine, J. D. Nociceptor interleukin 10 receptor 1 is critical for muscle analgesia induced by repeated bouts of eccentric exercise in the rat. Pain 158, 1481–1488 (2017).
Article PubMed PubMed Central CAS Google Scholar
Laumet, G. et al. Interleukin-10 resolves pain hypersensitivity induced by cisplatin by reversing sensory neuron hyperexcitability. Pain 161, 2344–2352 (2020).
Article PubMed PubMed Central Google Scholar
Sun, Q. et al. IRG1/itaconate increases IL-10 release to alleviate mechanical and thermal hypersensitivity in mice after nerve injury. Front. Immunol. 13, 1012442 (2022).
Article PubMed PubMed Central CAS Google Scholar
Üçeyler, N., Topuzoǧlu, T., Schießer, P., Hahnenkamp, S. & Sommer, C. IL-4 deficiency is associated with mechanical hypersensitivity in mice. PLoS ONE 6, e28205 (2011).
Article PubMed PubMed Central Google Scholar
Celik, M., Labuz, D., Keye, J., Glauben, R. & Machelska, H. IL-4 induces M2 macrophages to produce sustained analgesia via opioids. JCI Insight 5, e133093 (2020).
Article PubMed PubMed Central Google Scholar
Prado, J. et al. Cytokine receptor clustering in sensory neurons with an engineered cytokine fusion protein triggers unique pain resolution pathways. Proc. Natl Acad. Sci. USA 118, e2009647118 (2021).
Article PubMed PubMed Central CAS Google Scholar
Caterina, M. J. et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389, 816–824 (1997).
Article PubMed CAS Google Scholar
Xu, Z. Z. et al. Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. Nat. Med. 16, 592–597 (2010).
Article PubMed PubMed Central CAS Google Scholar
Wu, J. et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 339, 826–830 (2013).
Article PubMed CAS Google Scholar
Defaye, M. et al. Induction of antiviral interferon-stimulated genes by neuronal STING promotes the resolution of pain in mice. J. Clin. Invest. 134, e176474 (2024).
Article PubMed PubMed Central CAS Google Scholar
Donnelly, C. R. et al. STING controls nociception via type I interferon signalling in sensory neurons. Nature 591, 275–280 (2021). In this study, the authors found that neuron-intrinsic innate immune signaling via the IFN–STING pathway is important for controlling nociception in mice, and exogenous activation of this pathway suppressed excitability of nociceptors and reduced pain thresholds.
Article PubMed PubMed Central CAS Google Scholar
Wang, K. et al. STING suppresses bone cancer pain via immune and neuronal modulation. Nat. Commun. 12, 4558 (2021).
Article PubMed PubMed Central CAS Google Scholar
Binshtok, A. M. et al. Nociceptors are interleukin-1β sensors. J. Neurosci. 28, 14062 (2008).
Article PubMed PubMed Central CAS Google Scholar
Liu, X. J. et al. Nociceptive neurons regulate innate and adaptive immunity and neuropathic pain through MyD88 adapter. Cell Res. 24, 1374–1377 (2014).
Article PubMed PubMed Central CAS Google Scholar
Jain, A. et al. Nociceptor-immune interactomes reveal insult-specific immune signatures of pain. Nat. Immunol. 25, 1296–1305 (2024).
Article PubMed PubMed Central CAS Google Scholar
Kim, J. H., Park, J. S. & Park, D. Anti-allodynic effect of interleukin 10 in a mouse model of complex regional pain syndrome through reduction of NK1 receptor expression of microglia in the spinal cord. J. Pain. Res. 11, 1729–1741 (2018).
Article PubMed PubMed Central CAS Google Scholar
Mitsui, K. et al. Role of macrophage autophagy in postoperative pain and inflammation in mice. J. Neuroinflammation 20, 102 (2023).
Article PubMed PubMed Central CAS Google Scholar
de Souza, S. et al. Mast cell-derived chymases are essential for the resolution of inflammatory pain in mice. Preprint at bioRxiv https://doi.org/10.1101/2024.08.05.606617 (2024).
Starkl, P. et al. Mast cell-derived BH4 and serotonin are critical mediators of postoperative pain. Sci. Immunol. 9, 98 (2024).
Van Der Vlist, M. et al. Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain. Neuron https://doi.org/10.1016/j.neuron.2021.11.020 (2022).
Fischer, R. et al. TNFR2 promotes Treg-mediated recovery from neuropathic pain across sexes. Proc. Natl Acad. Sci. USA 116, 17045–17050 (2019).
Article PubMed PubMed Central CAS Google Scholar
Hu, R., Zhang, J., Liu, X., Huang, D. & Cao, Y. Q. Low-dose interleukin-2 and regulatory T cell treatments attenuate punctate and dynamic mechanical allodynia in a mouse model of sciatic nerve injury. J. Pain. Res. 14, 893–906 (2021).
Article PubMed PubMed Central Google Scholar
Austin, P. J., Kim, C. F., Perera, C. J. & Moalem-Taylor, G. Regulatory T cells attenuate neuropathic pain following peripheral nerve injury and experimental autoimmune neuritis. Pain 153, 1916–1931 (2012).
Article PubMed CAS Google Scholar
Laumet, G., Edralin, J. D., Dantzer, R., Heijnen, C. J. & Kavelaars, A. Cisplatin educates CD8+ T cells to prevent and resolve chemotherapy-induced peripheral neuropathy in mice. Pain 160, 1459–1468 (2019).
Article PubMed PubMed Central CAS Google Scholar
Singh, S. K. et al. CD8+ T cell-derived IL-13 increases macrophage IL-10 to resolve neuropathic pain. JCI Insight 7, e154194 (2022).
Parisien, M. et al. Genome-wide association studies with experimental validation identify a protective role for B lymphocytes against chronic post-surgical pain. Br. J. Anaesth. 133, 360–370 (2024).
Article PubMed PubMed Central CAS Google Scholar
Parisien, M. et al. Acute inflammatory response via neutrophil activation protects against the development of chronic pain. Sci. Transl. Med. 14, eabj9954 (2022). In individuals with resolved low back pain, there was an enrichment in neutrophil gene signatures compared to those with persistent pain, suggesting neutrophils promote resolution of pain. This was further shown in mice where administration of neutrophils promoted the resolution of inflammatory pain. In addition, the data in this study showed that the chronic use of nonsteroidal anti-inflammatory drugs was associated with persistent pain, which was recapitulated in animals.
Article PubMed PubMed Central CAS Google Scholar
Corder, G., Castro, D. C., Bruchas, M. R. & Scherrer, G. Endogenous and exogenous opioids in pain. Annu. Rev. Neurosci. 41, 453–473 (2018).
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