Decursin protects against DSS-induced experimental colitis in mice by inhibiting the cGAS-STING signaling pathway

Bulek K, Zhao J, Liao Y, Rana N, Corridoni D, Antanaviciute A, Chen X, Wang H, Qian W, Miller-Little WA, Swaidani S, Tang F, Willard BB, McCrae K, Kang Z, Dubyak GR, Cominelli F, Simmons A, Pizarro TT, Li X (2020) Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis. J Clin Invest 130(8):4218–4234

PubMed  PubMed Central  Google Scholar 

Canesso MCC, Lemos L, Neves TC, Marim FM, Castro TBR, Veloso ÉS, Queiroz CP, Ahn J, Santiago HC, Martins FS, Alves-Silva J, Ferreira E, Cara DC, Vieira AT, Barber GN, Oliveira SC, Faria AMC (2018) The cytosolic sensor STING is required for intestinal homeostasis and control of inflammation. Mucosal Immunol 11(3):820–834

Article  PubMed  Google Scholar 

Chen C, Pv Xu (2023) Cellular functions of cGAS-STING signaling. Trends Cell Biol 33(8):630–648

Article  PubMed  Google Scholar 

Chu Y, Yuan Q, Jiang H, Wu L, Xie Y, Zhang X, Li L (2024) A comprehensive review of the anticancer effects of decursin. Front Pharmacol 15:1303412

Article  PubMed  PubMed Central  Google Scholar 

Guo H, Guo H, Xie Y, Chen Y, Lu C, Yang Z, Zhu Y, Ouyang Y, Zhang Y, Wang X (2022) Mo3Se4 nanoparticle with ROS scavenging and multi-enzyme activity for the treatment of DSS-induced colitis in mice. Redox Bio 56:102441

Article  Google Scholar 

Hu Q, Ren H, Li G, Wang D, Zhou Q, Wu J, Zheng J, Huang J, Slade DA, Wu X, Ren J (2019) STING-mediated intestinal barrier dysfunction contributes to lethal sepsis. EBioMedicine 41:497–508

Article  PubMed  PubMed Central  Google Scholar 

Hu K, Yuan X, He H, Zhang H, Wang F, Qiao J (2022) Pharmacological mechanisms of chitotriose as a redox regulator in the treatment of rat inflammatory bowel disease. Biomed Pharmacother 150:112988

Article  PubMed  Google Scholar 

Islam SU, Lee JH, Shehzad A, Ahn EM, Lee YM, Lee YS (2018) Decursinol angelate inhibits LPS-induced macrophage polarization through modulation of the NFκB and MAPK signaling pathways. Molecules 23(8):1880

Kaplan GG (2015) The global burden of IBD: from 2015 to 2025. Nat Rev Gastroenterol Hepatol 12(12):720–7

Article  PubMed  Google Scholar 

Kaur S, Bansal Y, Kumar R, Bansal G (2020) A panoramic review of IL-6: structure, pathophysiological roles and inhibitors. Bioorg Med Chem 28(5):115327

Article  PubMed  Google Scholar 

Kim D, Go SH, Song Y, Lee DK, Park JR (2024) Decursin induces G1 cell cycle arrest and apoptosis through reactive oxygen species-mediated endoplasmic reticulum stress in human colorectal cancer cells in in vitro and xenograft models. Int J Mol Sci 25(18):9939

Article  PubMed  PubMed Central  Google Scholar 

Li MY, Zhang ZH, Wang Z, Zuo HX, Wang JY, Xing Y, Jin CH, Xu GH, Piao LX, Ma J, Jin X (2019) Convallatoxin protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB signaling through activation of PPARγ. Pharmacol Res 147:104355

Article  PubMed  Google Scholar 

Lousberg EL, Fraser CK, Tovey MG, Diener KR, Hayball JD (2010) Type I interferons mediate the innate cytokine response to recombinant fowlpox virus but not the induction of plasmacytoid dendritic cell-dependent adaptive immunity. J Virol 84(13):6549–63

Article  PubMed  PubMed Central  Google Scholar 

Lv QM, Lei HM, Wang SY, Zhang KR, Tang YB, Shen Y, Lu LM, Chen HZ, Zhu L (2023) Cancer cell-autonomous cGAS-STING response confers drug resistance. Cell Chem Biol 30(6):591-605.e4

Article  PubMed  Google Scholar 

Mahendran V, Liu F, Riordan SM, Grimm MC, Tanaka MM, Zhang L (2016) Examination of the effects of Campylobacter concisus zonula occludens toxin on intestinal epithelial cells and macrophages. Gut Pathog 8:18

Article  PubMed  PubMed Central  Google Scholar 

Martin GR, Blomquist CM, Henare KL, Jirik FR (2019) Stimulator of interferon genes (STING) activation exacerbates experimental colitis in mice. Sci Rep 9(1):14281

Article  PubMed  PubMed Central  Google Scholar 

Oh SR, Ok S, Jung TS, Jeon SO, Park JM, Jung JW, Ryu DS (2017) Protective effect of decursin and decursinol angelate-rich Angelica gigas Nakai extract on dextran sulfate sodium-induced murine ulcerative colitis. Asian Pac J Trop Med 10(9):864–870

Article  PubMed  Google Scholar 

Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, Nakaya R (1990) A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 98(3):694–702

Article  PubMed  Google Scholar 

Pai RK, Jairath V, Vande Casteele N, Rieder F, Parker CE, Lauwers GY (2018) The emerging role of histologic disease activity assessment in ulcerative colitis. Gastrointest Endosc 88(6):887–898

Article  PubMed  Google Scholar 

Park J, Cheon JH (2021) Incidence and prevalence of inflammatory bowel disease across Asia. Yonsei Med J 62(2):99–108

Article  PubMed  PubMed Central  Google Scholar 

Rauf A, Khalil AA, Rahman UU, Khalid A, Naz S, Shariati MA, Rebezov M, Urtecho EZ, de Albuquerque RDDG, Anwar S, Alamri A, Saini RK, Rengasamy KRR (2022) Recent advances in the therapeutic application of short-chain fatty acids (SCFAs): an updated review. Crit Rev Food Sci Nutr 62(22):6034–6054

Article  PubMed  Google Scholar 

Sasson AN, Ingram RJM, Zhang Z, Taylor LM, Ananthakrishnan AN, Kaplan GG, Ng SC, Ghosh S, Raman M (2021) The role of precision nutrition in the modulation of microbial composition and function in people with inflammatory bowel disease. Lancet Gastroenterol Hepatol 6(9):754–769

Article  PubMed  Google Scholar 

Slifer ZM, Blikslager AT (2020) The integral role of tight junction proteins in the repair of injured intestinal epithelium. Int J Mol Sci 21(3):972

Article  PubMed  PubMed Central  Google Scholar 

Thapa B, Pak S, Kwon HJ, Lee K (2019) Decursinol angelate ameliorates dextran sodium sulfate-induced colitis by modulating type 17 helper T cell responses [published correction appears in Biomol Ther (Seoul). 2020 Mar 1;28(2):211. https://doi.org/10.4062/biomolther.2019.221]. Biomol Ther (Seoul) 27(5):466-473

Ueda K, Sakai C, Ishida T, Morita K, Kobayashi Y, Horikoshi Y, Baba A, Okazaki Y, Yoshizumi M, Tashiro S, Ishida M (2023) Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway: application to a biomarker for atherosclerosis. Clin Sci (Lond) 37(2):163–180

Article  Google Scholar 

Wang J, Yao N, Chen Y, Li X, Jiang Z (2024) Research progress of cGAS-STING signaling pathway in intestinal diseases. Int Immunopharmacol 135:112271

Article  PubMed  Google Scholar 

Yoseph BP, Klingensmith NJ, Liang Z, Breed ER, Burd EM, Mittal R, Dominguez JA, Petrie B, Ford ML, Coopersmith CM (2016) Mechanisms of intestinal barrier dysfunction in sepsis. Shock 46(1):52–9

Article  PubMed  PubMed Central  Google Scholar 

Zhao Y, Zhan J, Sun C, Zhu S, Zhai Y, Dai Y, Wang X, Gao X (2024) Sishen Wan enhances intestinal barrier function via regulating endoplasmic reticulum stress to improve mice with diarrheal irritable bowel syndrome. Phytomedicine 129:155541

Article  PubMed  Google Scholar 

Zhu J, Dong X (2023) Decursin alleviates LPS-induced lung epithelial cell injury by inhibiting NF-κB pathway activation. Allergol Immunopathol (Madr) 51(1):37–43

Article  PubMed  Google Scholar 

Zou Y, Ghaderpour A, Munkhbileg B, Seo SU, Seong SY (2023) Taurodeoxycholate ameliorates DSS-induced colitis in mice. Int Immunopharmacol 122:110628

Article  PubMed  Google Scholar 

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