Araújo HD, Silva LR, Siqueira WN, Fonseca CS, Silva NH, Melo AM, Martins MC, Lima VL (2018) Toxicity of usnic acid from Cladoniasubstellata (lichen) to embryos and adults of Biomphalariaglabrata. Acta Trop 179:39–43
Arunkumar M, Gunaseelan S, KubendranAravind M, Mohankumar V, Anupam P, Harikrishnan M, Siva A, Ashokkumar B, Varalakshmi P (2021) Marine algal antagonists targeting 3CL protease and spike glycoprotein of SARS-CoV-2: a computational approach for anti-COVID-19 drug discovery. J Biomol Struct Dyn 1–28
Assogba P, Agbodjento E, Akotegnon R, Dougnon V, Klotoé JR (2021) Ethnopharmacological survey of six medicinal plants used in the traditional treatment of urinary tract infections and other infectious diseases. Nat Resour Hum Health 1:125–132
Aydin S, Kinalioglu K (2018) Comparative antimicrobial activity of crude extracts of Protoparmeliopsismuralis and Parmotremaperlatum lichens. Gazi Univ J Sci 31:687–698
Bačkorová M, Bačkor M, Mikeš J, Jendželovský R, Fedoročko P (2011) Variable responses of different human cancer cells to the lichen compounds parietin, atranorin, usnic acid and gyrophoric acid. Toxicol in Vitro 25:37–44
Bongmo LVL, Nouga AB, Happi GM, Tabekoueng GB, Lateef M, Waffo AFK, Ali MS, Choudhary MI, Wansi JD (2022) Phytochemical compounds of Guibourtiaehie and their antioxidant, urease and α-glucosidase inhibitory activities. Nat Resour Hum Health 2:306–312
Burkholder PR, Evans AW, McVeigh I, Thornton HK (1994) Antibiotic activity of lichens. Proc Natl Acad Sci U S A 30:250–255
Cakmak KC, Gülçin I (2019) Anticholinergic and antioxidant activities of usnic acid-an activity-structure insight. Toxicol Rep 6:1273–1280
Cancer Research UK (2021) Worldwide Cancer Statistics Available online: https://www.cancerresearchuk.org/health-professional/cancer-statistics/worldwide-cancer (accessed on 27 April 2021)
Cardile V, Graziano ACE, Avola R, Piovano M, Russo A (2017a) Potential anticancer activity of lichen secondary metabolite physodic acid. Chem Biol Interact Biol Interact 263:36–45
Cardile V, Graziano ACE, Avola R, Piovano M, Russo A (2017b) Potential anticancer activity of lichen secondary metabolite physodic acid. Chem Biol Interact 263:36–45
Article CAS PubMed Google Scholar
Crawford SD (2015) Lichens used in traditional medicine. In: Ranković B (ed) Lichen secondary metabolites. Springer, Cham, Switzerland, pp 31–97
Croce N, Pitaro M, Gallo V, Antonini G (2022) Toxicity of Usnic Acid: A Narrative Review. J Toxicol 2022(1):8244340. https://doi.org/10.1155/2022/8244340
Article CAS PubMed PubMed Central Google Scholar
Cumbane P, Estivila A, Magaia I (2022) A Comparative study on the antioxidant activity of Gladiolus dalenii Van Geel and nine commonly used substances to compare the antioxidant activity of foods and medicinal plants. Nat Resour Hum Health 2:228–235
Emsen B, Aslan A, Togar B, Turkez H (2016) In vitro antitumor activities of the lichen compounds olivetoric, physodic and psoromic acid in rat neuron and glioblastoma cells. Pharm Biol 54:1748–1762
Article CAS PubMed Google Scholar
Geng X, Zhang X, Zhou B, Zhang C, Tu J, Chen X, Wang J, Gao H, Qin G, Pan W (2018) Usnic acid induces cycle arrest, apoptosis, and autophagy in gastric cancer cells in vitro and in vivo. Med Sci Monit Int Med J Exp Clin Res 24:556–566
Golmohammadzadeh S, Jaafari MR, Hosseinzadeh H (2010) Does saffron have antisolar and moisturizing effects? Iran J Pharm Res 9:133
PubMed PubMed Central Google Scholar
Harikrishnan A, Veena V, Lakshmi B, Shanmugavalli R, Theres S, Prashantha CN, Shah T, Oshin K, Togam R, Nandi S (2021) Atranorin, an antimicrobial metabolite from lichen Parmotremarampoddense exhibited in vitro anti-breast cancer activity through interaction with Akt activity. J Biomol Struct Dyn 39:1248–1258
Article CAS PubMed Google Scholar
Jevapatarakul D, Jiraroj T, Payungporn S, Chavalit T, Khamwut A, T-Thienprasert NP (2020) Utilization of Cratoxylum formosum crude extract for synthesis of ZnOnanosheets: characterization, biological activities and effects on gene expression of nonmelanoma skin cancer cell. Biomed Pharmacother 130:110552
Article CAS PubMed Google Scholar
Khan MF, Nabila SA, Rashid RB, Rahman MS, Chowdhury AA, Rashid MA (2015) In silico molecular docking studies of lichen metabolites against cyclooxygenase-2 enzyme. Bangladesh Pharm J 18:90–96
Khan F, Yu H, Kim YM (2020) Bactericidal activity of usnic acid-chitosan nanoparticles against persister cells of biofilm-forming pathogenic bacteria. Mar Drugs 18:270
Article CAS PubMed PubMed Central Google Scholar
Khazaei Z, Sohrabivafa M, Momenabadi V, Moayed L, Goodarzi E (2019) Global cancer statistics 2018: globocan estimates of incidence and mortality worldwide prostate cancers and their relationship with the human development index. Adv Hum Biol 9:245–250
Koparal AT (2015) Anti-angiogenic and antiproliferative properties of the lichen substances (-)-usnic acid and vulpinic acid. Z FürNaturforschung C 70:159–164
Kumar K, Mishra JP, Singh RP (2020) Usnic acid induces apoptosis in human gastric cancer cells through ROS generation and DNA damage and causes up-regulation of DNA-PKcs and γ-H2A. X Phosphorylation Chem Biol Interact 315:108898
Article CAS PubMed Google Scholar
Kwong SP, Wang C (2020) Usnic acid-induced hepatotoxicity and cell death. Environ Toxicol Pharmacol 80:103493. https://doi.org/10.1016/j.etap.2020.103493
Article CAS PubMed Google Scholar
Kwong SP, Wang H, Shi L, Huang Z, Lu B, Cheng X, Chou G, Ji L, Wang C (2020) Identification of photodegraded derivatives of usnic acid with improved toxicity profile and UVA/UVB protection in normal human L02 hepatocytes and epidermal melanocytes. J Photochem Photobiol B 205:111814
Article CAS PubMed Google Scholar
Malhotra S, Subban R, Singh A (2008a) Lichens-role in traditional medicine and drug. Internet J Alter Med 5:1–5
Malhotra S, Subban RAVI, Singh A (2008b) Lichens-role in traditional medicine and drug discovery. Internet J Alter Med 5:1–5
Mariadoss AVA, Shalini RV, Agilan V, Franklin B, Sanjay JH, Alaa K, Tawfiq YG, Ernest MAA, D. (2019) Green synthesis, characterization and antibacterial activity of silver nanoparticles by Malusdomestica and its cytotoxic effect on (MCF-7) cell line. Microb Pathog 135:103609
Article CAS PubMed Google Scholar
Maulidiyah M, Darmawan A, Ahmad E, Musdalifah A, Wibowo D, Arham Z, Mustapa F, Nurdin IFA, Nurdin M (2021) Antioxidant activity-guided isolation of usnic acid and diffractaic acid compounds from lichen genus UsneaSp.J. Appl Pharm Sci 11:075–083
Murugan M, Rajendran K, Velmurugan T, Muthu S, Gundappa M, Thangavel S (2020) Antagonistic and antioxidant potencies of Centrosema pubescens Benth extracts against nosocomial infection pathogens. Biocatal Agric Biotechnol 29:101776
Nguyen NH, Ta QTH, Pham QT, Luong TNH, Phung VT, Duong TH, Vo VG (2020) Anticancer activity of novel plant extracts and compounds from Adenosma bracteosum (Bonati) in human lung and liver cancer cells. Molecules 25:2912
Article CAS PubMed PubMed Central Google Scholar
Noël A, Garnier A, Clément M, Rouaud I, Sauvager A, Bousarghin L, Vásquez-Ocmín P, Maciuk A, Tomasi S (2021) Lichen-associated bacteria transform antibacterial usnic acid to products of lower antibiotic activity. Phytochemistry 181:112535
Nugraha AS, Pratoko DK, Damayanti YD, Lestari ND, Laksono TA, Addy HS, Untari LF, Kusumawardani B, Wangchuk P (2019) Antibacterial and anticancer activities of nine lichens of Indonesian Java island. J Biol Act Prod Nat 9:39–46
Odabasoglu F, Cakir A, Suleyman H, Aslan A, Bayir Y, Halici M, Kazaz C (2006) Gastroprotective and antioxidant effects of usnic acid on indomethacin-induced gastric ulcer in rats. J Ethnopharmacol 103:59–65
Article CAS PubMed Google Scholar
Perry NB, Benn MH, Brennan NJ, Burgess EJ, Ellis G, Galloway DJ, Lorimer SD, Tangney RS (1999) Antimicrobial, antiviral and cytotoxic activity of New Zealand lichens. Lichenologist 31:627–636
Pradhan BK, Badola HK (2008) Ethnomedicinal plant use by Lepcha tribe of Dzongu Valley, bordering Khangchendzonga Biosphere Reserve, in North Sikkim. India J Ethnobiol Ethnomedicine 4:22
Rajendran K, Poornima S, Ponnusamy P (2020) Antimicrobial and antiproliferative activities of depside compound isolated from the mycobiont culture of Parmotrema austrosinense (Zahlbr.) Hale. J Pure Appl Microbiol 14:2525–2541
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