Bridging gap in treatment of polycystic ovarian syndrome through drug repurposing: what we achieved and where we are?

Al-Shalati J, Tulandi T (2011) The use of aromatase inhibitors in infertility and gynecology. Expert Rev Obstet Gynecol 6:415–421. https://doi.org/10.1586/eog.11.30

Article  CAS  Google Scholar 

Amer SA, Smith J, Mahran A, Fox P, Fakis A (2017) Double-blind randomized controlled trial of letrozole versus clomiphene citrate in subfertile women with polycystic ovarian syndrome. Hum Reprod (Oxford, England) 32:1631–1638. https://doi.org/10.1093/humrep/dex227

Article  CAS  Google Scholar 

Ardad RM, Manjappa AS, Dhawale SC, Kumbhar PS, Pore YV (2023) Concurrent oral delivery of non-oncology drugs through solid self-emulsifying system for repurposing in hepatocellular carcinoma. Drug Dev Ind Pharm 49:377–391. https://doi.org/10.1080/03639045.2023.2216785

Article  PubMed  CAS  Google Scholar 

Armanini D, Andrisani A, Bordin L, Sabbadin C (2016) Spironolactone in the treatment of polycystic ovary syndrome. Expert Opin Pharmacother 17:1713–1715. https://doi.org/10.1080/14656566.2016.1215430

Article  PubMed  Google Scholar 

Armanini D, Boscaro M, Bordin L, Sabbadin C (2022) Controversies in the pathogenesis, diagnosis and treatment of PCOS: Focus on insulin resistance, inflammation, and hyperandrogenism. Int J Mol Sci 23:4110. https://doi.org/10.3390/ijms23084110

Article  PubMed  PubMed Central  CAS  Google Scholar 

Banaszewska B, Pawelczyk L, Spaczynski RZ, Duleba AJ (2011) Effects of simvastatin and metformin on polycystic ovary syndrome after 6 months of treatment. J Clin Endocrinol Metab 96:3493–3501. https://doi.org/10.1210/jc.2011-0501

Article  PubMed  PubMed Central  CAS  Google Scholar 

Banaszewska B, Wrotyńska-Barczyńska J, Spaczynski RZ, Pawelczyk L, Duleba AJ (2016) Effects of resveratrol on polycystic ovary syndrome: A double-blind, randomized, placebo-controlled trial. J Clin Endocrinol Metab 101:4322–4328. https://doi.org/10.1210/jc.2016-1858

Article  PubMed  CAS  Google Scholar 

Bereda G (2022) Clinical Pharmacology of Spironolactone. J Diagn Case Rep 3:1–4

Article  Google Scholar 

Berenji E, ValipourMotlagh A, Fathi M, Esmaeili M, Izadi T, Rezvanian P, Zanjirband M, Safaeinejad Z, Nasr-Esfahani MH (2024) Discovering therapeutic possibilities for polycystic ovary syndrome by targeting XIST and its associated ceRNA network through the analysis of transcriptome data. Sci Rep 14:6180. https://doi.org/10.1038/s41598-024-56524-1

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bharali MD, Rajendran R, Goswami J, Singal K, Rajendran V (2022) Prevalence of polycystic ovarian syndrome in India: a systematic review and meta-analysis. Cureus 14:e32351. https://doi.org/10.7759/cureus.32351

Article  PubMed  PubMed Central  Google Scholar 

Cai M, Shao X, Xing F, Zhang Y, Gao X, Zeng Q, Dilimulati D, Qu S, Zhang M (2022) Efficacy of canagliflozin versus metformin in women with polycystic ovary syndrome: A randomized, open-label, noninferiority trial. Diabetes Obes Metab 24:312–320. https://doi.org/10.1111/dom.14583

Article  PubMed  CAS  Google Scholar 

Cassar S, Teede HJ, Moran LJ, Joham AE, Harrison CL, Strauss BJ, Stepto NK (2014) Polycystic ovary syndrome and anti-Müllerian hormone: role of insulin resistance, androgens, obesity and gonadotrophins. Clin Endocrinol 81:899–906. https://doi.org/10.1111/cen.12557

Article  CAS  Google Scholar 

Chen LL, Zheng JH (2021) Effects of atorvastatin on the insulin resistance in women of polycystic ovary syndrome: A systematic review and meta-analysis: A systematic review and meta-analysis. Medicine 100:e26289. https://doi.org/10.1097/MD.0000000000026289

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen T, Jia F, Yu Y, Zhang W, Wang C, Zhu S, Zhang N, Liu X (2022) Potential role of quercetin in polycystic ovary syndrome and its complications: A review. Molecules (Basel, Switzerland) 27:4476. https://doi.org/10.3390/molecules27144476

Article  PubMed  CAS  Google Scholar 

Corrie L, Gulati M, Vishwas S, KapoorB SSK, Awasthi A, Khursheed R (2021) Combination therapy of curcumin and fecal microbiota transplant: Potential treatment of polycystic ovarian syndrome. Med Hypotheses 154:110644. https://doi.org/10.1016/j.mehy.2021.110644

Article  PubMed  CAS  Google Scholar 

Corrie L, Singh SK, Gulati M, Awasthi A, Khursheed R, Kaur J, Vishwas S (2023a) Improvement in polycystic ovarian syndrome using pharmacological and non-pharmacological approaches: Current perspectives and principles. Curr Womens Health Rev 19:11–18

Article  Google Scholar 

Corrie L, Awasthi A, Kaur J, Vishwas S, Gulati M, Kaur IP, Gupta G, Kommineni N, Dua K, Singh SK (2023b) Interplay of gut Microbiota in polycystic Ovarian Syndrome: Role of gut Microbiota, mechanistic pathways and potential treatment strategies. Pharmaceuticals (Basel, Switzerland) 16:197. https://doi.org/10.3390/ph16020197

Article  PubMed  CAS  Google Scholar 

Corrie L, Singh H, Gulati M, Vishwas S, Chellappan DK, Gupta G, Paiva-Santos AC, Veiga F, Alotaibi F, Alam A, Eri RD, Prasher P, Adams J, Paudel KR, DuaK SSK (2024) Polysaccharide-fecal microbiota-based colon-targeted self-nanoemulsifying drug delivery system of curcumin for treating polycystic ovarian syndrome. Naunyn-Schmiedeberg’s Arch Pharmacol. https://doi.org/10.1007/s00210-024-03029-3

Article  Google Scholar 

Devi N, Boya C, Chhabra M, Bansal D (2020) N-acetyl-cysteine as adjuvant therapy in female infertility: a systematic review and meta-analysis. J Basic Clin Physiol Pharmacol 32:899–910. https://doi.org/10.1515/jbcpp-2020-0107

Article  PubMed  CAS  Google Scholar 

Dhankhar S, Chauhan S, Mehta DK, Nitika Saini K, Saini M, Das R, Gupta S, Gautam V (2023) Novel targets for potential therapeutic use in Diabetes mellitus. Diabetol Metab Syndr 15:17. https://doi.org/10.1186/s13098-023-00983-5

Article  PubMed  PubMed Central  Google Scholar 

Diamanti-Kandarakis E, Piperi C, Patsouris E, Korkolopoulou P, Panidis D, Pawelczyk L, Papavassiliou AG, Duleba AJ (2007) Immunohistochemical localization of advanced glycation end-products (AGEs) and their receptor (RAGE) in polycystic and normal ovaries. Histochem Cell Biol 127:581–589. https://doi.org/10.1007/s00418-006-0265-3

Article  PubMed  CAS  Google Scholar 

Doroszewska K, Milewicz T, Mrozińska S, Janeczko J, Rokicki R, Janeczko M, Warzecha D, Marianowski P (2019) Blood pressure in postmenopausal women with a history of polycystic ovary syndrome. PrzegladMenopauzalny 18:94–98. https://doi.org/10.5114/pm.2019.84039

Article  CAS  Google Scholar 

Du Q, Yang S, Wang YJ, Wu B, Zhao YY, Fan B (2012) Effects of thiazolidinediones on polycystic ovary syndrome: a meta-analysis of randomized placebo-controlled trials. Adv Ther 29:763–774. https://doi.org/10.1007/s12325-012-0044-6

Article  PubMed  CAS  Google Scholar 

Duda-Madej A, Stecko J, Sobieraj J, Szymańska N, Kozłowska J (2022) Naringenin and its derivatives-health-promoting phytobiotic against resistant bacteria and fungi in humans. Antibiotics (Basel, Switzerland) 11:1628. https://doi.org/10.3390/antibiotics11111628

Article  PubMed  CAS  Google Scholar 

Dunaif A (2016) Perspectives in polycystic ovary syndrome: From hair to eternity. J Clin Endocrinol Metab 101:759–768. https://doi.org/10.1210/jc.2015-3780

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dutta D, Bhattacharya S, Kumar M, Datta PK, Mohindra R, Sharma M (2023) Efficacy and safety of novel thiazolidinedione lobeglitazone for managing type-2 diabetes a meta-analysis. Diabetes Metabo Syndr 17:102697. https://doi.org/10.1016/j.dsx.2022.102697

Article  CAS  Google Scholar 

Elkind-Hirsch KE, Chappell N, Seidemann E, Storment J, Bellanger D (2021) Exenatide, dapagliflozin, or phentermine/topiramate differentially affect metabolic profiles in polycystic ovary syndrome. J Clin Endocrinol Metab 106:3019–3033. https://doi.org/10.1210/clinem/dgab408

Article  PubMed  Google Scholar 

Elkind-Hirsch KE, Chappell N, Shaler D, Storment J, Bellanger D (2022) Liraglutide 3 mg on weight, body composition, and hormonal and metabolic parameters in women with obesity and polycystic ovary syndrome: a randomized placebo-controlled-phase 3 study. Fertil Steril 118:371–381. https://doi.org/10.1016/j.fertnstert.2022.04.027

Article  PubMed  CAS  Google Scholar 

留言 (0)

沒有登入
gif