Transcriptomic alterations in APP/PS1 mice astrocytes lead to early postnatal axon initial segment structural changes

Crystal H, Dickson D, Fuld P, Masur D, Scott R, Mehler M, Masdeu J, Kawas C, Aronson M, Wolfson L (1988) Clinico-pathologic studies in dementia: nondemented subjects with pathologically confirmed Alzheimer’s disease. Neurology 38:1682–1687

Article  CAS  PubMed  Google Scholar 

Sturchio A, Dwivedi AK, Malm T, Wood MJA, Cilia R, Sharma JS, Hill EJ, Schneider LS, Graff-Radford NR, Mori H et al (2022) High soluble amyloid-beta42 predicts normal cognition in amyloid-positive individuals with Alzheimer’s disease-causing mutations. J Alzheimers Dis 90:333–348

Article  CAS  PubMed  PubMed Central  Google Scholar 

Harris SS, Wolf F, De Strooper B, Busche MA (2020) Tipping the scales: peptide-dependent dysregulation of neural circuit dynamics in Alzheimer’s disease. Neuron 107:417–435

Article  CAS  PubMed  Google Scholar 

Maestu F, de Haan W, Busche MA, DeFelipe J (2021) Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology. Ageing Res Rev 69:101372

Article  CAS  PubMed  Google Scholar 

Palop JJ, Mucke L (2009) Epilepsy and cognitive impairments in Alzheimer disease. Arch Neurol 66:435–440

Article  PubMed  PubMed Central  Google Scholar 

Bender KJ, Trussell LO (2012) The physiology of the axon initial segment. Annu Rev Neurosci 35:249–265

Article  CAS  PubMed  Google Scholar 

Rasband MN (2010) The axon initial segment and the maintenance of neuronal polarity. Nat Rev Neurosci 11:552–562

Article  CAS  PubMed  Google Scholar 

Grubb MS, Burrone J (2010) Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability. Nature 465:1070–1074

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kuba H (2010) Plasticity at the axon initial segment. Commun Integr Biol 3:597–598

Article  PubMed  PubMed Central  Google Scholar 

Del Puerto A, Fronzaroli-Molinieres L, Perez-Alvarez MJ, Giraud P, Carlier E, Wandosell F, Debanne D, Garrido JJ (2015) ATP-P2X7 receptor modulates axon initial segment composition and function in physiological conditions and brain injury. Cereb Cortex 25:2282–2294

Article  PubMed  Google Scholar 

Sun Z, Wang B, Chen C, Li C, Zhang Y (2021) 5-HT6R null mutatrion induces synaptic and cognitive defects. Aging Cell 20:e13369

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tapia M, Dominguez A, Zhang W, Del Puerto A, Ciorraga M, Benitez MJ, Guaza C, Garrido JJ (2017) Cannabinoid receptors modulate neuronal morphology and AnkyrinG density at the axon initial segment. Front Cell Neurosci 11:5

Article  PubMed  PubMed Central  Google Scholar 

Schafer DP, Jha S, Liu F, Akella T, McCullough LD, Rasband MN (2009) Disruption of the axon initial segment cytoskeleton is a new mechanism for neuronal injury. J Neurosci 29:13242–13254

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sobotzik JM, Sie JM, Politi C, Del Turco D, Bennett V, Deller T, Schultz C (2009) AnkyrinG is required to maintain axo-dendritic polarity in vivo. Proc Natl Acad Sci U S A 106:17564–17569

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marin MA, Ziburkus J, Jankowsky J, Rasband MN (2016) Amyloid-beta plaques disrupt axon initial segments. Exp Neurol 281:93–98

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sohn PD, Tracy TE, Son HI, Zhou Y, Leite RE, Miller BL, Seeley WW, Grinberg LT, Gan L (2016) Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment. Mol Neurodegener 11:47

Article  PubMed  PubMed Central  Google Scholar 

Sun X, Wu Y, Gu M, Liu Z, Ma Y, Li J, Zhang Y (2014) Selective filtering defect at the axon initial segment in Alzheimer’s disease mouse models. Proc Natl Acad Sci U S A 111:14271–14276

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sanchez-Mut JV, Aso E, Panayotis N, Lott I, Dierssen M, Rabano A, Urdinguio RG, Fernandez AF, Astudillo A, Martin-Subero JI et al (2013) DNA methylation map of mouse and human brain identifies target genes in Alzheimer’s disease. Brain 136:3018–3027

Article  PubMed  PubMed Central  Google Scholar 

Vitale P, Salgueiro-Pereira AR, Lupascu CA, Willem M, Migliore R, Migliore M, Marie H (2021) Analysis of age-dependent alterations in excitability properties of CA1 pyramidal neurons in an APPPS1 model of Alzheimer’s disease. Front Aging Neurosci 13:668948

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ciccone R, Franco C, Piccialli I, Boscia F, Casamassa A, de Rosa V, Cepparulo P, Cataldi M, Annunziato L, Pannaccione A (2019) Amyloid beta-induced upregulation of Na(v)1.6 underlies neuronal hyperactivity in Tg2576 Alzheimer’s disease mouse model. Sci Rep 9:13592

Article  PubMed  PubMed Central  Google Scholar 

Manville RW, Abbott GW (2021) The amyloid precursor protein C99 fragment modulates voltage-gated potassium channels. Cell Physiol Biochem 55:157–170

Article  PubMed  Google Scholar 

Hatch RJ, Wei Y, Xia D, Gotz J (2017) Hyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment. Acta Neuropathol 133:717–730

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sohn PD, Huang CT, Yan R, Fan L, Tracy TE, Camargo CM, Montgomery KM, Arhar T, Mok SA, Freilich R et al (2019) Pathogenic Tau impairs axon initial segment plasticity and excitability homeostasis. Neuron 104(458–470):e455

Google Scholar 

Baalman KL, Cotton RJ, Rasband SN, Rasband MN (2013) Blast wave exposure impairs memory and decreases axon initial segment length. J Neurotrauma 30:741–751

Article  PubMed  PubMed Central  Google Scholar 

Kaphzan H, Buffington SA, Jung JI, Rasband MN, Klann E (2011) Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome. J Neurosci 31:17637–17648

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu S, Cordner ZA, Xiong J, Chiu CT, Artola A, Zuo Y, Nelson AD, Kim TY, Zaika N, Woolums BM et al (2017) Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorder. Proc Natl Acad Sci U S A 114:10479–10484

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singh D (2022) Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer’s disease. J Neuroinflamm 19:206

Article  CAS  Google Scholar 

Brandebura AN, Paumier A, Onur TS, Allen NJ (2023) Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders. Nat Rev Neurosci 24:23–39

Article  CAS  PubMed  Google Scholar 

Carter SF, Scholl M, Almkvist O, Wall A, Engler H, Langstrom B, Nordberg A (2012) Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B and 18F-FDG. J Nucl Med 53:37–46

Article  CAS  PubMed  Google Scholar 

Kwon HS, Koh SH (2020) Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes. Transl Neurodegener 9:42

Article 

留言 (0)

沒有登入
gif