Kovacic JC, Dimmeler S, Harvey RP, Finkel T, Aikawa E, Krenning G, Baker AH. Endothelial to mesenchymal transition in Cardiovascular Disease: JACC State-of-the-art review. J Am Coll Cardiol. 2019;73:190–209. https://doi.org/10.1016/j.jacc.2018.09.089.

Article  PubMed  PubMed Central  Google Scholar 

Piera-Velazquez S, Jimenez SA. Endothelial to mesenchymal transition: role in physiology and in the Pathogenesis of Human diseases. Physiol Rev. 2019;99:1281–324. https://doi.org/10.1152/physrev.00021.2018.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ranchoux B, Antigny F, Rucker-Martin C, Hautefort A, Péchoux C, Bogaard HJ, Dorfmüller P, Remy S, Lecerf F, Planté S, Chat S, Fadel E, Houssaini A, Anegon I, Adnot S, Simonneau G, Humbert M, Cohen-Kaminsky S, Perros F. Endothelial-to-mesenchymal transition in pulmonary hypertension. Circulation. 2015;131:1006–18. https://doi.org/10.1161/circulationaha.114.008750.

Article  CAS  PubMed  Google Scholar 

Chen PY, Qin L, Baeyens N, Li G, Afolabi T, Budatha M, Tellides G, Schwartz MA, Simons M. Endothelial-to-mesenchymal transition drives atherosclerosis progression. J Clin Invest. 2015;125:4514–28. https://doi.org/10.1172/jci82719.

Article  PubMed  PubMed Central  Google Scholar 

Piera-Velazquez S, Mendoza FA, Jimenez SA. Endothelial to mesenchymal transition (EndoMT) in the Pathogenesis of Human Fibrotic diseases. J Clin Med. 2016;5. https://doi.org/10.3390/jcm5040045.

Medici D, Shore EM, Lounev VY, Kaplan FS, Kalluri R, Olsen BR. Conversion of vascular endothelial cells into multipotent stem-like cells. Nat Med. 2010;16:1400–6. https://doi.org/10.1038/nm.2252.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li DK, Chen XR, Wang LN, Wang JH, Li JK, Zhou ZY, Li X, Cai LB, Zhong SS, Zhang JJ, Zeng YM, Zhang QB, Fu XY, Lyu XM, Li MY, Huang ZX, Yao KT. Exosomal HMGA2 protein from EBV-positive NPC cells destroys vascular endothelial barriers and induces endothelial-to-mesenchymal transition to promote metastasis. Cancer Gene Ther. 2022;29:1439–51. https://doi.org/10.1038/s41417-022-00453-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kimoto A, Kadoi Y, Tsuruda T, Kim YS, Miyoshi M, Nomoto Y, Nakata Y, Miyake M, Miyashita K, Shimizu K, Ajiki T, Hori Y. Exosomes in ascites from patients with human pancreatic cancer enhance remote metastasis partially through endothelial-mesenchymal transition. Pancreatology. 2023;23:377–88. https://doi.org/10.1016/j.pan.2023.04.002.

Article  CAS  PubMed  Google Scholar 

Gurung S, Perocheau D, Touramanidou L, Baruteau J. The exosome journey: from biogenesis to uptake and intracellular signalling. Cell Commun Signal. 2021;19:47. https://doi.org/10.1186/s12964-021-00730-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maas SLN, Breakefield XO, Weaver AM. Extracellular vesicles: Unique Intercellular Delivery vehicles. Trends Cell Biol. 2017;27:172–88. https://doi.org/10.1016/j.tcb.2016.11.003.

Article  CAS  PubMed  Google Scholar 

van Niel G, D’Angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol. 2018;19:213–28. https://doi.org/10.1038/nrm.2017.125.

Article  CAS  PubMed  Google Scholar 

Lu X, Yao C, Sun L, Li Z. Plasmon-enhanced biosensors for microRNA analysis and cancer diagnosis. Biosens Bioelectron. 2022;203:114041. https://doi.org/10.1016/j.bios.2022.114041.

Article  CAS  PubMed  Google Scholar 

Li X, Wu L, Tian X, Zheng W, Yuan M, Tian X, Zuo H, Song H, Shen Z. miR-29a-3p in Exosomes from Heme Oxygenase-1 modified bone marrow mesenchymal stem cells alleviates Steatotic Liver Ischemia-Reperfusion Injury in rats by suppressing ferroptosis via Iron responsive element binding protein 2. Oxid Med Cell Longev. 2022;2022(6520789). https://doi.org/10.1155/2022/6520789.

Zhu D, Liu S, Huang K, Wang Z, Hu S, Li J, Li Z, Cheng K. Intrapericardial Exosome Therapy dampens Cardiac Injury via activating Foxo3. Circ Res. 2022;131:e135–50. https://doi.org/10.1161/circresaha.122.321384.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi G, Long Z, De la Vega RE, Behfar A, Moran SL, Evans C, Zhao C. Purified exosome product enhances chondrocyte survival and regeneration by modulating inflammation and promoting chondrogenesis. Regen Med. 2023;18:55–71. https://doi.org/10.2217/rme-2022-0132.

Article  CAS  PubMed  Google Scholar 

Lu Y, Han G, Zhang Y, Zhang L, Li Z, Wang Q, Chen Z, Wang X, Wu J. M2 macrophage-secreted exosomes promote metastasis and increase vascular permeability in hepatocellular carcinoma. Cell Commun Signal. 2023;21:299. https://doi.org/10.1186/s12964-022-00872-w.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang D, Wang X, Si M, Yang J, Sun S, Wu H, Cui S, Qu X, Yu X. Exosome-encapsulated miRNAs contribute to CXCL12/CXCR4-induced liver metastasis of colorectal cancer by enhancing M2 polarization of macrophages. Cancer Lett. 2020;474:36–52. https://doi.org/10.1016/j.canlet.2020.01.005.

Article  CAS  PubMed  Google Scholar 

Ma J, Wang P, Liu Y, Zhao L, Li Z, Xue Y. Krüppel-like factor 4 regulates blood-tumor barrier permeability via ZO-1, occludin and claudin-5. J Cell Physiol. 2014;229:916–26. https://doi.org/10.1002/jcp.24523.

Article  CAS  PubMed  Google Scholar 

Liu K, Dou R, Yang C, Di Z, Shi D, Zhang C, Song J, Fang Y, Huang S, Xiang Z, Zhang W, Wang S, Xiong B. Exosome-transmitted miR-29a induces colorectal cancer metastasis by destroying the vascular endothelial barrier. Carcinogenesis. 2023;44:356–67. https://doi.org/10.1093/carcin/bgad013.

Article  CAS  PubMed  Google Scholar 

Chen CW, Fu M, Du ZH, Zhao F, Yang WW, Xu LH, Li SL, Ge XY. Long noncoding RNA MRPL23-AS1 promotes adenoid cystic carcinoma lung metastasis. Cancer Res. 2020;80:2273–85. https://doi.org/10.1158/0008-5472.Can-19-0819.

Article  CAS  PubMed  Google Scholar 

Shu L, Li X, Liu Z, Li K, Shi A, Tang Y, Zhao L, Huang L, Zhang Z, Zhang D, Huang S, Lian S, Sheng G, Yan Z, Zhang Z, Xu Y. Bile exosomal miR-182/183-5p increases cholangiocarcinoma stemness and progression by targeting HPGD and increasing PGE2 generation. Hepatology. 2024;79:307–22. https://doi.org/10.1097/hep.0000000000000437.

Article  PubMed  Google Scholar 

Xu G, Shi X, Liu H, Shen C, Yang B, Zhang T, Chen X, Zhao D, Yang J, Hao Y, Cui H, Yuan X, Liu X, Zhang K, Zheng H. Functional analysis and Proteomics Profiling of Extracellular vesicles from swine plasma infected by African swine fever virus. Front Cell Infect Microbiol. 2022;12:809135. https://doi.org/10.3389/fcimb.2022.809135.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schwab A, Meyering SS, Lepene B, Iordanskiy S, van Hoek ML, Hakami RM, Kashanchi F. Extracellular vesicles from infected cells: potential for direct pathogenesis. Front Microbiol. 2015;6:1132. https://doi.org/10.3389/fmicb.2015.01132.

Article  PubMed  PubMed Central  Google Scholar 

Aga M, Bentz GL, Raffa S, Torrisi MR, Kondo S, Wakisaka N, Yoshizaki T, Pagano JS, Shackelford J. Exosomal HIF1α supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes. Oncogene. 2014;33:4613–22. https://doi.org/10.1038/onc.2014.66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li H, Chi X, Li R, Ouyang J, Chen Y. HIV-1-infected cell-derived exosomes promote the growth and progression of cervical cancer. Int J Biol Sci. 2019;15:2438–47. https://doi.org/10.7150/ijbs.38146.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wei XC, Xia YR, Zhou P, Xue X, Ding S, Liu LJ, Zhu F. Hepatitis B core antigen modulates exosomal miR-135a to target vesicle-associated membrane protein 2 promoting chemoresistance in hepatocellular carcinoma. World J Gastroenterol. 2021;27:8302–22. https://doi.org/10.3748/wjg.v27.i48.8302.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao X, Sun L, Mu T, Yi J, Ma C, Xie H, Liu M, Tang H. An HBV-encoded miRNA activates innate immunity to restrict HBV replication. J Mol Cell Biol. 2020;12:263–76. https://doi.org/10.1093/jmcb/mjz104.

Article