Eke PI, Borgnakke WS, Genco RJ. Recent epidemiologic trends in periodontitis in the USA. Periodontol. 2000. 2020;82:257 – 67.

Chen MX, Zhong YJ, Dong QQ, Wong HM, Wen YF. Global, regional, and national burden of severe periodontitis, 1990–2019: an analysis of the global burden of Disease Study 2019. J Clin Periodontol. 2021;48:1165–88.

Article  PubMed  Google Scholar 

Fakheran O, Birang R, Schmidlin PR, Razavi SM, Behfarnia P. Retro MTA and tricalcium phosphate/retro MTA for guided tissue regeneration of periodontal dehiscence defects in a dog model: a pilot study. Biomaterials Res. 2019;23:14.

Article  Google Scholar 

Paknejad M, Eslaminejad MB, Ghaedi B, Rokn A, Khorsand A, Etemad-Moghadam S, et al. Isolation and Assessment of mesenchymal stem cells derived from bone marrow: histologic and histomorphometric study in a Canine Periodontal defect. J Oral Implantol. 2015;41:284–91.

Article  PubMed  Google Scholar 

Pellegrini G, Pagni G, Rasperini G. Surgical approaches based on Biological objectives: GTR versus GBR techniques. Int J Dent. 2013;2013:521547.

Article  PubMed  PubMed Central  Google Scholar 

Aydin S, Şahin F. Stem cells derived from Dental tissues. Adv Exp Med Biol. 2019;1144:123–32.

Article  PubMed  CAS  Google Scholar 

Sui B, Zheng C, Zhao W, Xuan K, Li B, Jin Y. Mesenchymal condensation in tooth development and regeneration: a focus on translational aspects of organogenesis. Physiol Rev. 2023;103:1899–964.

Article  PubMed  CAS  Google Scholar 

Andrukhov O, Behm C, Blufstein A, Rausch-Fan X. Immunomodulatory properties of dental tissue-derived mesenchymal stem cells: implication in disease and tissue regeneration. World J Stem Cells. 2019;11:604–17.

Article  PubMed  PubMed Central  Google Scholar 

Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. P Natl Acad Sci Usa. 2000;97:13625–30.

Article  CAS  Google Scholar 

Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, et al. SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci U S A. 2003;100:5807–12.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet. 2004;364:149–55.

Article  PubMed  CAS  Google Scholar 

Morsczeck C, Gotz W, Schierholz J, Zeilhofer F, Kuhn U, Mohl C, et al. Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth. Matrix Biol. 2005;24:155–65.

Article  PubMed  CAS  Google Scholar 

Sonoyama W, Liu Y, Fang D, Yamaza T, Seo BM, Zhang C, et al. Mesenchymal stem cell-mediated functional tooth regeneration in swine. PLoS ONE. 2006;1:e79.

Article  PubMed  PubMed Central  Google Scholar 

Zhang Q, Shi S, Liu Y, Uyanne J, Shi Y, Shi S, et al. Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis. J Immunol. 2009;183:7787–98.

Article  PubMed  CAS  Google Scholar 

Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018;7:1535750.

Article  PubMed  PubMed Central  Google Scholar 

Janockova J, Slovinska L, Harvanova D, Spakova T, Rosocha J. New therapeutic approaches of mesenchymal stem cells-derived exosomes. J Biomed Sci. 2021;28:39.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li Y, Duan X, Chen Y, Liu B, Chen G. Dental stem cell-derived extracellular vesicles as promising therapeutic agents in the treatment of diseases. Int J Oral Sci. 2022;14:2.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ma L, Rao N, Jiang H, Dai Y, Yang S, Yang H, et al. Small extracellular vesicles from dental follicle stem cells provide biochemical cues for periodontal tissue regeneration. Stem Cell Res Ther. 2022;13:92.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Frantz C, Stewart KM, Weaver VM. The extracellular matrix at a glance. J Cell Sci. 2010;123:4195–200.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kapp TG, Rechenmacher F, Neubauer S, Maltsev OV, Cavalcanti-Adam EA, Zarka R, et al. A comprehensive evaluation of the Activity and Selectivity Profile of ligands for RGD-binding integrins. Sci Rep-Uk. 2017;7:39805.

Article  CAS  Google Scholar 

Lin H, Chen H, Zhao X, Chen Z, Zhang P, Tian Y, et al. Advances in mesenchymal stem cell conditioned medium-mediated periodontal tissue regeneration. J Transl Med. 2021;19:456.

Article  PubMed  PubMed Central  Google Scholar 

Xiong X, Yang X, Dai H, Feng G, Zhang Y, Zhou J, et al. Extracellular matrix derived from human urine-derived stem cells enhances the expansion, adhesion, spreading, and differentiation of human periodontal ligament stem cells. Stem Cell Res Ther. 2019;10:396.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tavelli L, McGuire MK, Zucchelli G, Rasperini G, Feinberg SE, Wang H, et al. Extracellular matrix-based scaffolding technologies for periodontal and peri-implant soft tissue regeneration. J Periodontol. 2020;91:17–25.

Article  PubMed  Google Scholar 

Takewaki M, Kajiya M, Takeda K, Sasaki S, Motoike S, Komatsu N, et al. MSC/ECM Cellular complexes Induce Periodontal tissue regeneration. J Dent Res. 2017;96:984–91.

Article  PubMed  CAS  Google Scholar 

Huang CC, Narayanan R, Warshawsky N, Ravindran S. Dual ECM biomimetic scaffolds for Dental Pulp Regenerative Applications. Front Physiol. 2018;9:495.

Article  PubMed  PubMed Central  Google Scholar 

Nowwarote N, Petit S, Ferre FC, Dingli F, Laigle V, Loew D, et al. Extracellular Matrix Derived from Dental Pulp Stem cells promotes mineralization. Front Bioeng Biotechnol. 2021;9:740712.

Article  PubMed  Google Scholar 

Phothichailert S, Nowwarote N, Fournier BPJ, Trachoo V, Roytrakul S, Namangkalakul W, et al. Effects of decellularized extracellular matrix derived from Jagged1-treated human dental pulp stem cells on biological responses of stem cells isolated from apical papilla. Front Cell Dev Biology. 2022;10:948812.

Article  Google Scholar 

Nagata M, Iwasaki K, Akazawa K, Komaki M, Yokoyama N, Izumi Y, et al. Conditioned medium from Periodontal ligament stem cells enhances Periodontal Regeneration. Tissue Eng Part A. 2017;23:367–77.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Qiu J, Wang X, Zhou H, Zhang C, Wang Y, Huang J, et al. Enhancement of periodontal tissue regeneration by conditioned media from gingiva-derived or periodontal ligament-derived mesenchymal stem cells: a comparative study in rats. Stem Cell Res Ther. 2020;11:42.

Article  PubMed  PubMed Central  CAS  Google Scholar 

de Jong T, Bakker AD, Everts V, Smit TH. The intricate anatomy of the periodontal ligament and its development: lessons for periodontal regeneration. J Periodontal Res. 2017;52:965–74.

Article  PubMed  Google Scholar 

Strydom H, Maltha JC, Kuijpers-Jagtman AM, Von den Hoff JW. The oxytalan fibre network in the periodontium and its possible mechanical function. Arch Oral Biol. 2012;57:1003–11.

Article  PubMed  CAS  Google Scholar 

Sodek J. A comparison of the rates of synthesis and turnover of collagen and non-collagen proteins in adult rat periodontal tissues and skin using a microassay. Arch Oral Biol. 1977;22:655–65.