Advances in retinal pigment epithelial cell transplantation for retinal degenerative diseases

Wong WL, Su X, Li X, Cheung CMG, Klein R, Cheng C-Y, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health. 2014;2:e106–16.

Article  PubMed  Google Scholar 

Tanna P, Strauss RW, Fujinami K, Michaelides M. Stargardt disease: clinical features, molecular genetics, animal models and therapeutic options. Br J Ophthalmol. 2017;101:25–30.

Article  PubMed  Google Scholar 

Chaumet-Riffaud AE, Chaumet-Riffaud P, Cariou A, Devisme C, Audo I, Sahel J-A, et al. Impact of retinitis pigmentosa on quality of life, mental health, and employment among young adults. Am J Ophthalmol. 2017;177:169–74.

Article  PubMed  Google Scholar 

Fleckenstein M, Keenan TD, Guymer RH, Chakravarthy U, Schmitz-Valckenberg S, Klaver CC, et al. Age-related macular degeneration. Nat Rev Dis Primers. 2021;7:31.

Article  PubMed  Google Scholar 

Schwartz SD, Regillo CD, Lam BL, Eliott D, Rosenfeld PJ, Gregori NZ, et al. Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt’s macular dystrophy: follow-up of two open-label phase 1/2 studies. Lancet. 2015;385:509–16.

Article  PubMed  Google Scholar 

Mandai M, Watanabe A, Kurimoto Y, Hirami Y, Morinaga C, Daimon T, et al. Autologous induced stem-cell–derived retinal cells for macular degeneration. N Engl J Med. 2017;376:1038–46.

Article  CAS  PubMed  Google Scholar 

Schwartz SD, Hubschman J-P, Heilwell G, Franco-Cardenas V, Pan CK, Ostrick RM, et al. Embryonic stem cell trials for macular degeneration: a preliminary report. Lancet. 2012;379:713–20.

Article  CAS  PubMed  Google Scholar 

da Cruz L, Fynes K, Georgiadis O, Kerby J, Luo YH, Ahmado A, et al. Phase 1 clinical study of an embryonic stem cell–derived retinal pigment epithelium patch in age-related macular degeneration. Nat Biotechnol. 2018;36:328–37.

Article  PubMed  Google Scholar 

Dujardin C, Habeler W, Monville C, Letourneur D, Simon-Yarza T. Advances in the engineering of the outer blood-retina barrier: From in-vitro modelling to cellular therapy. Bioact Mater. 2024;31:151–77.

CAS  PubMed  Google Scholar 

Liu H, Jing L, Sun J, Huang D. An overview of scaffolds for retinal pigment epithelium research. Procedia Manuf. 2021;53:492–9.

Article  Google Scholar 

Yang S, Zhou J, Li D. Functions and diseases of the retinal pigment epithelium. Front Pharmacol. 2021;12:727870.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tian X, Cui Z, Liu S, Zhou J, Cui R. Melanosome transport and regulation in development and disease. Pharmacol Th. 2021;219:107707.

Article  CAS  Google Scholar 

Strauss O. The retinal pigment epithelium in visual function. Physiol Rev. 2005;85:845–81.

Article  CAS  PubMed  Google Scholar 

Steinmetz JD, Bourne RRA, Briant PS, Flaxman SR, Taylor HRB, Jonas JB, et al. Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study. Lancet Glob Health. 2021;9:e144–60.

Article  Google Scholar 

Newton F, Megaw R. Mechanisms of photoreceptor death in retinitis pigmentosa. Genes. 2020;11:1120.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cornish KS, Ho J, Downes S, Scott NW, Bainbridge J, Lois N. The epidemiology of Stargardt disease in the United Kingdom. Ophthalmol Retina. 2017;1:508–13.

Article  Google Scholar 

Cremers FP, Lee W, Collin RW, Allikmets R. Clinical spectrum, genetic complexity and therapeutic approaches for retinal disease caused by ABCA4 mutations. Prog Retin Eye Res. 2020;79:100861.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kawasaki H, Suemori H, Mizuseki K, Watanabe K, Urano F, Ichinose H, et al. Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity. Proc Natl Acad Sci U S A. 2002;99:1580–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haruta M, Sasai Y, Kawasaki H, Amemiya K, Ooto S, Kitada M, et al. In Vitro and In Vivo Characterization of Pigment Epithelial Cells Differentiated from Primate Embryonic Stem Cells. Invest Ophthalmol Vis Sci. 2004;45:1020–5.

Article  PubMed  Google Scholar 

Buchholz DE, Hikita ST, Rowland TJ, Friedrich AM, Hinman CR, Johnson LV, et al. Derivation of Functional Retinal Pigmented Epithelium from Induced Pluripotent Stem Cells. Stem Cells. 2009;27:2427–34.

Article  CAS  PubMed  Google Scholar 

Meyer JS, Shearer RL, Capowski EE, Wright LS, Wallace KA, McMillan EL, et al. Modeling early retinal development with human embryonic and induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2009;106:16698–703.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Idelson M, Alper R, Obolensky A, Ben-Shushan E, Hemo I, Yachimovich-Cohen N, et al. Directed Differentiation of Human Embryonic Stem Cells into Functional Retinal Pigment Epithelium Cells. Cell Stem Cell. 2009;5:396–408.

Article  CAS  PubMed  Google Scholar 

Sonoda S, Spee C, Barron E, Ryan SJ, Kannan R, Hinton DR. A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells. Nat Protoc. 2009;4:662–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Regha K, Bhargava M, Al-Mubaarak A, Chai C, Parikh BH, Liu Z, et al. Customized strategies for high-yield purification of retinal pigment epithelial cells differentiated from different stem cell sources. Sci Rep. 2022;12:15563.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kashani AH, Lebkowski JS, Rahhal FM, Avery RL, Salehi-Had H, Dang W, et al. A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration. Sci Transl Med. 2018;10:eaao4097.

Article  PubMed  Google Scholar 

Sugita S, Futatsugi Y, Ishida M, Edo A, Takahashi M. Retinal pigment epithelial cells derived from induced pluripotent stem (iPS) cells suppress or activate T cells via costimulatory signals. Int J Mol Sci. 2020;21:6507.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singh RB, Blanco T, Mittal SK, Alemi H, Chauhan SK, Chen Y, et al. Pigment epithelium–derived factor enhances the suppressive phenotype of regulatory T cells in a murine model of dry eye disease. Am J Pathol. 2021;191:720–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sugita S, Iwasaki Y, Makabe K, Kimura T, Futagami T, Suegami S, et al. Lack of T Cell Response to iPSC-derived retinal pigment epithelial cells from HLA homozygous donors. Stem Cell Rep. 2016;7:619–34.

Article  CAS  Google Scholar 

Zhao Q, Lai K. Role of immune inflammation regulated by macrophage in the pathogenesis of age-related macular degeneration. Exp Eye Res. 2024;239:109770.

Article  CAS  PubMed  Google Scholar 

Fanelli G, Romano M, Lombardi G, Sacks SH. Soluble Collectin 11 (CL-11) Acts as an immunosuppressive molecule potentially used by stem cell-derived retinal epithelial cells to modulate T cell response. Cells. 2023;12:1805.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mehat MS, Sundaram V, Ripamonti C, Robson AG, Smith AJ, Borooah S, et al. Transplantation of human embryonic stem cell-derived retinal pigment epithelial cells in macular degeneration. Ophthalmol. 2018;125:1765–75.

Article  Google Scholar 

Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131:861–72.

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