Giannelou P, Simopoulou M, Grigoriadis S, Makrakis E, Kontogeorgi A, Pantou A, et al. The conundrum of poor ovarian response: from diagnosis to treatment. Diagnostics (Basel). 2020;10(9):687.

Article  PubMed  Google Scholar 

Venetis CA, Kolibianakis EM, Tarlatzi TB, Tarlatzis BC. Evidence-based management of poor ovarian response. Ann N Y Acad Sci. 2010;1205(1):199–206.

Article  CAS  PubMed  Google Scholar 

Drakopoulos P, Blockeel C, Stoop D, Camus M, De Vos M, Tournaye H, Polyzos NP. Conventional ovarian stimulation and single embryo transfer for IVF/ICSI. How many oocytes do we need to maximize cumulative live birth rates after utilization of all fresh and frozen embryos? Hum Reprod. 2016;31(2):370–6.

PubMed  Google Scholar 

Law YJ, Zhang N, Kolibianakis EM, Costello MF, Keller E, Chambers GM, Venetis CA. Is there an optimal number of oocytes retrieved at which live birth rates or cumulative live birth rates per aspiration are maximized after ART? A systematic review. Reprod Biomed Online. 2021;42(1):83–104.

Article  PubMed  Google Scholar 

Ferraretti AP, La Marca A, Fauser BC, Tarlatzis B, Nargund G, Gianaroli L, Definition EPOR. ESHRE consensus on the definition of ‘poor response’ to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum Reprod. 2011;26(7):1616–24.

Article  CAS  PubMed  Google Scholar 

Alviggi C, Andersen C, Buehler K, Conforti A, De Placido G, Esteves S, et al. Poseidon Group (patient-Oriented strategies encompassing IndividualizeD oocyte number). A new more detailed stratification of low responders to ovarian stimulation: from a poor ovarian response to a low prognosis concept. Fertil Steril. 2016;105(6):1452–3.

Article  PubMed  Google Scholar 

Annalisa R, Dominic S, Nikolaos PP. Diminished ovarian reserve and poor ovarian response: diagnostic and therapeutic management. Front Physiol. 2022;13:827678.

Nunez-Calonge R, Cortes S, Gutierrez Gonzalez LM, Kireev R, Vara E, Ortega L, et al. Oxidative stress in follicular fluid of young women with low response compared with fertile oocyte donors. Reprod Biomed Online. 2016;32(4):446–56.

Article  CAS  PubMed  Google Scholar 

Taghavi SA, Ashrafi M, Mehdizadeh M, Karimian L, Joghataie MT, Aflatoonian R. Toll-like receptors expression in follicular cells of patients with poor ovarian response. Int J Fertil Steril. 2014;8(2):183–92.

PubMed  Google Scholar 

Luddi A, Capaldo A, Focarelli R, Gori M, Morgante G, Piomboni P, De Leo V. Antioxidants reduce oxidative stress in follicular fluid of aged women undergoing IVF. Reprod Biol Endocrinol. 2016;14(1):57.

Article  PubMed  Google Scholar 

Regan SLP, Knight PG, Yovich JL, Leung Y, Arfuso F, Dharmarajan A. Granulosa Cell apoptosis in the ovarian Follicle-A changing view. Front Endocrinol (Lausanne). 2018;9:61.

Article  PubMed  Google Scholar 

Kaltsas A, Zikopoulos A, Moustakli E, Zachariou A, Tsirka G, Tsiampali C, et al. The Silent threat to women’s fertility: uncovering the devastating effects of oxidative stress. Antioxid (Basel). 2023;12(8):1490.

Article  CAS  Google Scholar 

Adashi EY. Endocrinology of the ovary. Hum Reprod. 1994;9(5):815–27.

Article  CAS  PubMed  Google Scholar 

Redza-Dutordoir M, Averill-Bates DA. Activation of apoptosis signalling pathways by reactive oxygen species. Biochim Biophys Acta Mol Cell Res. 2016;1863(12):2977–92.

Article  CAS  Google Scholar 

Yan F, Zhao Q, Li Y, Zheng Z, Kong X, Shu C, et al. The role of oxidative stress in ovarian aging: a review. J Ovarian Res. 2022;15(1):100.

Article  CAS  PubMed  Google Scholar 

Regan S, Knight P, Yovich J, Leung Y, Arfuso F, Dharmarajan A. Granulosa cell apoptosis in the ovarian follicle-a changing view. Front Endocrinol. 2018;9(2018):61.

Article  Google Scholar 

Ralla B, Stephan C, Meller S, Dietrich D, Kristiansen G, Jung K. Nucleic acid-based biomarkers in body fluids of patients with urologic malignancies. Crit Rev Clin Lab Sci. 2014;51(4):200–31.

Article  CAS  PubMed  Google Scholar 

Scalici E, Traver S, Molinari N, Mullet T, Monforte M, Vintejoux E, Hamamah S. Cell-free DNA in human follicular fluid as a biomarker of embryo quality. Hum Reprod. 2014;29(12):2661–9.

Article  CAS  PubMed  Google Scholar 

Traver S, Assou S, Scalici E, Haouzi D, Al-Edani T, Belloc S, Hamamah S. Cell-free nucleic acids as non-invasive biomarkers of gynecological cancers, ovarian, endometrial and obstetric disorders and fetal aneuploidy. Hum Reprod Update. 2014;20(6):905–23.

Article  CAS  PubMed  Google Scholar 

Baka S, Malamitsi-Puchner A. Novel follicular fluid factors influencing oocyte developmental potential in IVF: a review. Reprod Biomed Online. 2006;12(4):500–6.

Article  CAS  PubMed  Google Scholar 

Ficicioglu C, Cenksoy PO, Yildirim G, Kaspar C. Which cut-off value of serum anti-Müllerian hormone level can predict poor ovarian reserve, poor ovarian response to stimulation and in vitro fertilization success? A prospective data analysis. Gynecol Endocrinol. 2014;30(5):372–6.

Article  CAS  PubMed  Google Scholar 

Seifer DB, Gardiner AC, Ferreira KA, Peluso JJ. Apoptosis as a function of ovarian reserve in women undergoing in vitro fertilization. Fertil Steril. 1996;66(4):593–8.

Article  CAS  PubMed  Google Scholar 

Jeve YB, Bhandari HM. Effective treatment protocol for poor ovarian response: a systematic review and meta-analysis. J Hum Reprod Sci. 2016;9(2):70–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Blumenfeld Z. What is the best regimen for ovarian stimulation of poor responders in ART/IVF? Front Endocrinol (Lausanne). 2020;11:192.

Article  PubMed  Google Scholar 

Gong Y, Luo S, Fan P, Jin S, Zhu H, Deng T, et al. Growth hormone alleviates oxidative stress and improves oocyte quality in Chinese women with polycystic ovary syndrome: a randomized controlled trial. Sci Rep. 2020;10(1):18769.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu Y, Nisenblat V, Lu C, Li R, Qiao J, Zhen X, Wang S. Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial. Reprod Biol Endocrinol. 2018;16(1):29.

Article  PubMed  PubMed Central  Google Scholar 

Wang J, Liu B, Wen J, Qu B. The role of dehydroepiandrosterone in improving in vitro fertilization outcome in patients with DOR/POR: a systematic review and Meta- analysis. Comb Chem High Throughput Screen. 2023;26(5):916–27.

Article  CAS  PubMed  Google Scholar 

Kohandel Z, Farkhondeh T, Aschner M, Samarghandian S. Nrf2 a molecular therapeutic target for Astaxanthin. Biomed Pharmacother. 2021;137:111374.

Article  CAS  PubMed  Google Scholar 

Ambati RR, Phang SM, Ravi S, Aswathanarayana RG. Astaxanthin: sources, extraction, stability, biological activities and its commercial applications–a review. Mar Drugs. 2014;12(1):128–52.

Article  PubMed  PubMed Central  Google Scholar 

Suyono EA, Pradani L, Mu’avatun U, Habiba RN, Rohma EF. Combination of blue, red, white, and ultraviolet lights for increasing carotenoids and biomass of microalga Haematococcus pluvialis. Procedia Environ Sci. 2015;28:399–405.

Article  CAS  Google Scholar 

Howden R. Nrf2 and cardiovascular defense. Oxid Med Cell Longev. 2013;2013(1):104308.

Higuera-Ciapara I, Felix-Valenzuela L, Goycoolea F. Astaxanthin: a review of its chemistry and applications. Crit Rev Food Sci Nutr. 2006;46(2):185–96.

Article  CAS  PubMed  Google Scholar 

Kohandel Z, Farkhondeh T, Aschner M, Pourbagher-Shahri AM, Samarghandian S. Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases. Biomed Pharmacother. 2022;145: 112179.

Article  CAS  PubMed  Google Scholar 

Zhang H, Tsao R. Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects. Curr Opin Food Sci. 2016;8:33–42.