Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Miyata, Y. et al. Membrane structure-responsive lipid scrambling by TMEM63B to control plasma membrane lipid distribution. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-024-01411-6 (2024).