Phytocannabinoids restore seizure-induced alterations in emotional behaviour in male rats

Engel J. Introduction to temporal lobe epilepsy. Epilepsy Res. 1996;26:141–50.

Article  PubMed  Google Scholar 

Rho JM, White HS. Brief history of anti‐seizure drug development. Epilepsia Open. 2018;3:114–9.

Article  PubMed  PubMed Central  Google Scholar 

Eddy CM, Rickards HE, Cavanna AE. The cognitive impact of antiepileptic drugs. Ther Adv Neurol Disord. 2011;4:385–407.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bridgeman MB, Abazia DT. Medicinal Cannabis: History, Pharmacology, And Implications for the Acute Care Setting. P T. 2017;42:180–8.

PubMed  PubMed Central  Google Scholar 

Perucca E. Cannabinoids in the Treatment of Epilepsy: Hard Evidence at Last? J Epilepsy Res. 2017;7:61–76.

Article  PubMed  PubMed Central  Google Scholar 

Zaheer S, Kumar D, Khan MT, Giyanwani PR, Kiran F. Epilepsy and Cannabis: A Literature Review. Cureus. 2018;10:e3278.

PubMed  PubMed Central  Google Scholar 

Bedse G, Colangeli R, Lavecchia AM, Romano A, Altieri F, Cifani C, et al. Role of the basolateral amygdala in mediating the effects of the fatty acid amide hydrolase inhibitor URB597 on HPA axis response to stress. Eur Neuropsychopharmacol. 2014;24:1511–23.

Article  CAS  PubMed  Google Scholar 

Morena M, Patel S, Bains JS, Hill MN. Neurobiological Interactions Between Stress and the Endocannabinoid System. Neuropsychopharmacology. 2016;41:80–102.

Article  CAS  PubMed  Google Scholar 

Hurd YL, Yoon M, Manini AF, Hernandez S, Olmedo R, Ostman M, et al. Early Phase in the Development of Cannabidiol as a Treatment for Addiction: Opioid Relapse Takes Initial Center Stage. Neurotherapeutics. 2015;12:807–15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rapin L, Gamaoun R, El Hage C, Arboleda MF, Prosk E. Cannabidiol use and effectiveness: real-world evidence from a Canadian medical cannabis clinic. J Cannabis Res. 2021;3:19.

Article  PubMed  PubMed Central  Google Scholar 

Lee JLC, Bertoglio LJ, Guimarães FS, Stevenson CW. Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders. Br J Pharmacol. 2017;174:3242–56.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hasbi A, Madras BK, George SR. Endocannabinoid System and Exogenous Cannabinoids in Depression and Anxiety: A Review. Brain Sci. 2023;13:325.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fogaça MV, Reis FMCV, Campos AC, Guimarães FS. Effects of intra-prelimbic prefrontal cortex injection of cannabidiol on anxiety-like behavior: involvement of 5HT1A receptors and previous stressful experience. Eur Neuropsychopharmacol. 2014;24:410–9.

Article  PubMed  Google Scholar 

Fagherazzi EV, Garcia VA, Maurmann N, Bervanger T, Halmenschlager LH, Busato SB, et al. Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders. Psychopharmacol. 2012;219:1133–40.

Article  CAS  Google Scholar 

Navarrete F, García-Gutiérrez MS, Gasparyan A, Austrich-Olivares A, Manzanares J. Role of Cannabidiol in the Therapeutic Intervention for Substance Use Disorders. Front Pharmacol. 2021;12:626010.

Cheng D, Spiro AS, Jenner AM, Garner B, Karl T. Long-term cannabidiol treatment prevents the development of social recognition memory deficits in Alzheimer’s disease transgenic mice. J Alzheimers Dis. 2014;42:1383–96.

Article  CAS  PubMed  Google Scholar 

Chen K, Ratzliff A, Hilgenberg L, Gulyás A, Freund TF, Smith M, et al. Long-term plasticity of endocannabinoid signaling induced by developmental febrile seizures. Neuron. 2003;39:599–611.

Article  CAS  PubMed  Google Scholar 

Romigi A, Bari M, Placidi F, Marciani MG, Malaponti M, Torelli F, et al. Cerebrospinal fluid levels of the endocannabinoid anandamide are reduced in patients with untreated newly diagnosed temporal lobe epilepsy. Epilepsia. 2010;51:768–72.

Article  CAS  PubMed  Google Scholar 

Colangeli R, Morena M, Pittman QJ, Hill MN, Teskey GC. Anandamide Signaling Augmentation Rescues Amygdala Synaptic Function and Comorbid Emotional Alterations in a Model of Epilepsy. J Neurosci. 2020;40:6068–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Colangeli, Morena R, Werner M, Thompson A, Stelt RJ, van der M, et al. 2-AG-Mediated Control of GABAergic Signaling Is Impaired in a Model of Epilepsy. J Neurosci. 2023;43:571–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Di Marzo V, Piscitelli F. The Endocannabinoid System and its Modulation by Phytocannabinoids. Neurotherapeutics. 2015;12:692–8.

Article  PubMed  PubMed Central  Google Scholar 

Jacobson MR, Watts JJ, Boileau I, Tong J, Mizrahi R. A systematic review of phytocannabinoid exposure on the endocannabinoid system: Implications for psychosis. Eur Neuropsychopharmacol. 2019;29:330–48.

Article  CAS  PubMed  Google Scholar 

Maccarrone M. Phytocannabinoids and endocannabinoids: different in nature. Rend Fis Acc Lincei. 2020;31:931–8.

Article  Google Scholar 

Busquets-Garcia A, Gomis-González M, Srivastava RK, Cutando L, Ortega-Alvaro A, Ruehle S, et al. Peripheral and central CB1 cannabinoid receptors control stress-induced impairment of memory consolidation. Proc Natl Acad Sci USA. 2016;113:9904–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bedse G, Hartley ND, Neale E, Gaulden A, Patrick T, Kingsley P, et al. Functional Redundancy Between Canonical Endocannabinoid Signaling Systems in the Modulation of Anxiety. Biol Psychiatry. 2017;82:488–99.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smirnov MS, Kiyatkin EA. Behavioral and temperature effects of delta 9-tetrahydrocannabinol in human-relevant doses in rats. Brain Res. 2008;1228:145–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Manwell LA, Ford B, Matthews BA, Heipel H, Mallet PE. A vapourized Δ(9)-tetrahydrocannabinol (Δ(9)-THC) delivery system part II: comparison of behavioural effects of pulmonary versus parenteral cannabinoid exposure in rodents. J Pharm Toxicol Methods. 2014;70:112–9.

Article  CAS  Google Scholar 

Moore CF, Weerts EM. Cannabinoid tetrad effects of oral Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in male and female rats: sex, dose-effects and time course evaluations. Psychopharmacol. 2022;239:1397–408.

Article  CAS  Google Scholar 

Cuttler C, Mischley LK, Sexton M. Sex Differences in Cannabis Use and Effects: A Cross-Sectional Survey of Cannabis Users. Cannabis Cannabinoid Res. 2016;1:166–75.

Article  PubMed  PubMed Central  Google Scholar 

Baglot SL, Hume C, Petrie GN, Aukema RJ, Lightfoot SHM, Grace LM, et al. Pharmacokinetics and central accumulation of delta-9-tetrahydrocannabinol (THC) and its bioactive metabolites are influenced by route of administration and sex in rats. Sci Rep. 2021;11:23990.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim J, De Jesus O. Medication Routes of Administration. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.

Blair RDG. Temporal Lobe Epilepsy Semiology. Epilepsy Res Treat. 2012;2012:751510.

PubMed  PubMed Central  Google Scholar 

Racine RJ. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol. 1972;32:281–94.

Article 

留言 (0)

沒有登入
gif