The Protective Role of Baicalin in the Regulation of NLRP3 Inflammasome in Different Diseases

Zhao, H., et al. (2022). The Role of H(2)S Regulating NLRP3 Inflammasome in Diabetes. International Journal of Molecular Sciences, 23(9), 4818.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu, X., et al. (2022). The Role of Endoplasmic Reticulum Stress and NLRP3 Inflammasome in Liver Disorders. International Journal of Molecular Sciences, 23(7), 3528.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bai, B., et al. (2020). NLRP3 inflammasome in endothelial dysfunction. Cell Death & Disease, 11(9), 776.

Article  CAS  Google Scholar 

O’Connor, Jr., W., et al. (2003). Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties. The Journal of Immunology, 171(12), 6329–33.

Article  PubMed  Google Scholar 

Halle, A., et al. (2008). The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nature Immunology, 9(8), 857–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhong, Y., Kinio, A., & Saleh, M. (2013). Functions of NOD-Like Receptors in Human Diseases. Frontiers in Immunology, 4, 333.

Article  PubMed  PubMed Central  Google Scholar 

Cai, X., et al. (2014). Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation. Cell, 156(6), 1207–1222.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu, A., et al. (2014). Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell, 156(6), 1193–1206.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Próchnicki, T., Mangan, M.S., & Latz, E. (2016) Recent insights into the molecular mechanisms of the NLRP3 inflammasome activation. F1000Research, 5, F1000 Faculty Rev-1469.

Davidovich, P., Higgins, C. A., Najda, Z., Longley, D. B., & Martin, S. J. (2023). cFLIPL acts as a suppressor of TRAIL- and Fas-initiated inflammation by inhibiting assembly of caspase-8/FADD/RIPK1 NF-κB-activating complexes. Cell Reports, 42(12), 113476.

Article  CAS  PubMed  Google Scholar 

Chen, J., Mei, Q., Wang, L., & Wei, Y. (2024). DEFB114 protein enhances host resistance to fungal infection through the NOD1/2-ATG16L1-NF-κB signaling pathway. Bioorganic Chemistry, 146, 107245.

Article  CAS  PubMed  Google Scholar 

Mridha, A. R., Wree, A., Robertson, A. A. B., Yeh, M. M., Johnson, C. D., Van Rooyen, D. M., Haczeyni, F., Teoh, N. C., Savard, C., & Ioannou, G. N., et al. (2017). NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. Journal of Hepatology, 66, 1037–1046. https://doi.org/10.1016/j.jhep.2017.01.022.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cho, S., Ying, F., & Sweeney, G. (2023). Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease. Biomedical Journal., 46(5), 100624.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang, S. Y., Tian, T., Li, W. J., Liu, T., Wang, C., Hu, G., Du, R. H., Liu, Y., & Lu, M. (2023). Mefloquine targets NLRP3 to reduce lipopolysaccharide-induced systemic inflammation and neural injury. EMBO reports, 24(10), e57101.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang, J. W., Mao, B., Tao, R. J., Fan, L. C., Lu, H. W., Ge, B. X., & Xu, J. F. (2020). Corticosteroids alleviate lipopolysaccharide-induced inflammation and lung injury via inhibiting NLRP3-inflammasome activation. Journal of Cellular and Molecular Medicine, 24(21), 12716–12725.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Faria, S. S., Costantini, S., de Lima, V. C. C., de Andrade, V. P., Rialland, M., Cedric, R., Budillon, A., & Magalhães, K. G. (2021). NLRP3 inflammasome-mediated cytokine production and pyroptosis cell death in breast cancer. Journal of Biomedical Science, 28, 26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Toldo, S., & Abbate, A. (2024). The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases. Nature Reviews. Cardiology., 21(4), 219–237.

CAS  PubMed  Google Scholar 

Liu, B., Mao, X., & Huang, D., et al. (2019). Novel role of NLRP3-inflammasome in regulation of lipogenesis in fasting-induced hepatic steatosis. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy., 12, 801–811.

Article  CAS  PubMed  Google Scholar 

Zhao, T., et al. (2019). Scutellaria baicalensis Georgi. (Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology. Journal of Pharmacy and Pharmacology, 71(9), 1353–1369.

Article  CAS  PubMed  Google Scholar 

Chen, G., et al., Baicalin alleviates hyperglycemia-induced endothelial impairment 1 via Nrf2. Journal of Endocrinology, 2018.

Fang, J., et al. (2018). Baicalin provides neuroprotection in traumatic brain injury mice model through Akt/Nrf2 pathway. Drug Design. Development and Therapy, 12, 2497–2508.

Article  CAS  Google Scholar 

Huang, T., Liu, Y., & Zhang, C. (2019). Pharmacokinetics and Bioavailability Enhancement of Baicalin: A Review. European Journal of Drug Metabolism and Pharmacokinetics, 44(2), 159–168.

Article  PubMed  Google Scholar 

Hu, Z., et al. (2022). An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways. Iranian Journal of Basic Medical Sciences, 25(1), 14–26.

PubMed  PubMed Central  Google Scholar 

Ganguly, R., Gupta, A., & Pandey, A. K. (2022). Role of baicalin as a potential therapeutic agent in hepatobiliary and gastrointestinal disorders: A review. World Journal of Gastroenterology, 28(26), 3047–3062.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fang, P., et al. (2020). Baicalin and its aglycone: a novel approach for treatment of metabolic disorders. Pharmacological Reports, 72(1), 13–23.

Article  CAS  PubMed  Google Scholar 

Ming, J., Zhuoneng, L., & Guangxun, Z. (2018). Protective role of flavonoid baicalin from Scutellaria baicalensis in periodontal disease pathogenesis: A literature review. Complementary Therapies in Medicine, 38, 11–18.

Article  PubMed  Google Scholar 

Dinda, B., et al. (2017). Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders. European Journal of Medicinal Chemistry, 131, 68–80.

Article  CAS  PubMed  Google Scholar 

Xiao, J. R., & Do, C. W. (2014). and C.H. To, Potential therapeutic effects of baicalein, baicalin, and wogonin in ocular disorders. Journal of Ocular Pharmacology and Therapeutics, 30(8), 605–14.

Article  CAS  PubMed  Google Scholar 

Sowndhararajan, K., et al. (2018). Neuroprotective and Cognitive Enhancement Potentials of Baicalin: A Review. Brain Sciences, 8(6), 104.

Article  PubMed  PubMed Central  Google Scholar 

Liang, W., Huang, X., & Chen, W. (2017). The Effects of Baicalin and Baicalein on Cerebral Ischemia: A Review. Aging and disease, 8(6), 850–867.

Article  PubMed  PubMed Central  Google Scholar 

Wang, L., et al. (2022). Latest research progress on anticancer effect of baicalin and its aglycone baicalein. Archives of Pharmacal Research, 45(8), 535–557.

Article  CAS  PubMed  Google Scholar 

Ungvari, Z., et al. (2018). Mechanisms of Vascular Aging. Circulation Research, 123(7), 849–867.

Article  CAS  PubMed 

留言 (0)

沒有登入
gif