Sex-specific and developmental effects of early life adversity on stress reactivity are rescued by postnatal knockdown of 5-HT1A autoreceptors

Kessler RC, McLaughlin KA, Green JG, et al. Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys. Br J Psychiatry. 2010;197:378–85. https://doi.org/10.1192/bjp.bp.110.080499.

Article  PubMed  PubMed Central  Google Scholar 

Nutt DJ. Neurobiological mechanisms in generalized anxiety disorder. J Clin Psychiatry. 2001;62 11:22–7.

Google Scholar 

Malave L, van Dijk MT, Anacker C. Early life adversity shapes neural circuit function during sensitive postnatal developmental periods. Transl Psychiatry. 2022;12:306. https://doi.org/10.1038/s41398-022-02092-9.

Article  PubMed  PubMed Central  Google Scholar 

Daskalakis NP, Bagot RC, Parker KJ, Vinkers CH, de Kloet ER. The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome. Psychoneuroendocrinology. 2013;38:1858–73. https://doi.org/10.1016/j.psyneuen.2013.06.008.

Article  PubMed  PubMed Central  Google Scholar 

Anacker C, O’Donnell KJ, Meaney MJ. Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function. Dialogues Clin Neurosci. 2014;16:321–33.

Article  PubMed  PubMed Central  Google Scholar 

van Bodegom M, Homberg JR, Henckens MJAG. Modulation of the hypothalamic-pituitary-adrenal axis by early life stress exposure. Front Cell Neurosci. 2017;11:87 https://doi.org/10.3389/fncel.2017.00087.

Article  PubMed  PubMed Central  Google Scholar 

Heim C, Newport DJ, Wagner D, Wilcox MM, Miller AH, Nemeroff CB. The role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: a multiple regression analysis. Depress Anxiety. 2002;15:117–25. https://doi.org/10.1002/da.10015.

Article  PubMed  Google Scholar 

Heim C, Newport DJ, Heit S, et al. Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. JAMA. 2000;284:592–7. https://doi.org/10.1001/jama.284.5.592.

Article  PubMed  Google Scholar 

Lajud N, Roque A, Cajero M, Gutiérrez-Ospina G, Torner L. Periodic maternal separation decreases hippocampal neurogenesis without affecting basal corticosterone during the stress hyporesponsive period, but alters HPA axis and coping behavior in adulthood. Psychoneuroendocrinology. 2012;37(Mar):410–20. https://doi.org/10.1016/j.psyneuen.2011.07.011.

Article  PubMed  Google Scholar 

Murgatroyd C, Patchev AV, Wu Y, et al. Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci. 2009;12:1559–66. https://doi.org/10.1038/nn.2436.

Article  PubMed  Google Scholar 

Wu Y, Patchev AV, Daniel G, Almeida OF, Spengler D. Early-life stress reduces DNA methylation of the Pomc gene in male mice. Endocrinology. 2014;155:1751–62. https://doi.org/10.1210/en.2013-1868.

Article  PubMed  Google Scholar 

Chen J, Evans AN, Liu Y, Honda M, Saavedra JM, Aguilera G. Maternal deprivation in rats is associated with corticotrophin-releasing hormone (CRH) promoter hypomethylation and enhances CRH transcriptional responses to stress in adulthood. J Neuroendocrinol. 2012;24:1055–64. https://doi.org/10.1111/j.1365-2826.2012.02306.x.

Article  PubMed  PubMed Central  Google Scholar 

Uchida S, Hara K, Kobayashi A, et al. Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents. J Neurosci. 2010;30:15007–18. https://doi.org/10.1523/JNEUROSCI.1436-10.2010.

Article  PubMed  PubMed Central  Google Scholar 

Daskalakis NP, Diamantopoulou A, Claessens SEF, et al. Early experience of a novel-environment in isolation primes a fearful phenotype characterized by persistent amygdala activation. Psychoneuroendocrinology. 2014;39:39–57. https://doi.org/10.1016/j.psyneuen.2013.09.021.

Article  PubMed  Google Scholar 

Rice CJ, Sandman CA, Lenjavi MR, Baram TZ. A novel mouse model for acute and long-lasting consequences of early life stress. Endocrinology. 2008;149:4892–900. https://doi.org/10.1210/en.2008-0633.

Article  PubMed  PubMed Central  Google Scholar 

Arp JM, Ter Horst JP, Loi M, et al. Blocking glucocorticoid receptors at adolescent age prevents enhanced freezing between repeated cue-exposures after conditioned fear in adult mice raised under chronic early life stress. Neurobiol Learn Mem. 2016;133:30–38. https://doi.org/10.1016/j.nlm.2016.05.009.

Article  PubMed  Google Scholar 

Bolton JL, Short AK, Othy S, et al. Early stress-induced impaired microglial pruning of excitatory synapses on immature CRH-expressing neurons provokes aberrant adult stress responses. Cell Rep. 2022;38:110600 https://doi.org/10.1016/j.celrep.2022.110600.

Article  PubMed  PubMed Central  Google Scholar 

Gunn BG, Cunningham L, Cooper MA, et al. Dysfunctional astrocytic and synaptic regulation of hypothalamic glutamatergic transmission in a mouse model of early-life adversity: relevance to neurosteroids and programming of the stress response. J Neurosci. 2013;33:19534–54. https://doi.org/10.1523/JNEUROSCI.1337-13.2013.

Article  PubMed  PubMed Central  Google Scholar 

Anacker C, Zunszain PA, Carvalho LA, Pariante CM. The glucocorticoid receptor: pivot of depression and of antidepressant treatment? Psychoneuroendocrinology. 2011;36:415–25. https://doi.org/10.1016/j.psyneuen.2010.03.007.

Article  PubMed  PubMed Central  Google Scholar 

Anacker C, Cattaneo A, Luoni A, et al. Glucocorticoid-related molecular signaling pathways regulating hippocampal neurogenesis. Neuropsychopharmacology. 2013;38:872–83. https://doi.org/10.1038/npp.2012.253.

Article  PubMed  PubMed Central  Google Scholar 

Anacker C, Cattaneo A, Musaelyan K, et al. Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis. Proc Natl Acad Sci USA. 2013;110:8708–13. https://doi.org/10.1073/pnas.1300886110.

Article  PubMed  PubMed Central  Google Scholar 

David DJ, Samuels BA, Rainer Q, et al. Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. Neuron. 2009;62:479–93. https://doi.org/10.1016/j.neuron.2009.04.017. S0896-6273(09)00298-0 [pii]

Article  PubMed  PubMed Central  Google Scholar 

Anacker C, Luna VM, Stevens GS, et al. Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus. Nature. 2018;559:98–102. https://doi.org/10.1038/s41586-018-0262-4. 07

Article  PubMed  PubMed Central  Google Scholar 

Snyder JS, Soumier A, Brewer M, Pickel J, Cameron HA Adult hippocampal neurogenesis buffers stress responses and depressive behaviour. Nature. 2011;10287 [pii]. https://doi.org/10.1038/nature10287.

Ivy AS, Rex CS, Chen Y, et al. Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve excessive activation of CRH receptors. J Neurosci. 2010;30:13005–15. https://doi.org/10.1523/JNEUROSCI.1784-10.2010.

Article  PubMed  PubMed Central  Google Scholar 

Bath KG, Manzano-Nieves G, Goodwill H. Early life stress accelerates behavioral and neural maturation of the hippocampus in male mice. Horm Behav. 2016;82:64–71. https://doi.org/10.1016/j.yhbeh.2016.04.010.

Article  PubMed  PubMed Central  Google Scholar 

Youssef M, Atsak P, Cardenas J, Kosmidis S, Leonardo ED, Dranovsky A. Early life stress delays hippocampal development and diminishes the adult stem cell pool in mice. Sci Rep. 2019;9:4120. https://doi.org/10.1038/s41598-019-40868-0.

Article  PubMed  PubMed Central  Google Scholar 

Lucassen PJ, Oomen CA, Naninck EF, et al. Regulation of Adult Neurogenesis and Plasticity by (Early) Stress, Glucocorticoids, and Inflammation. Cold Spring Harb Perspect Biol. 2015;7:a021303. https://doi.org/10.1101/cshperspect.a021303.

Article  PubMed  PubMed Central  Google Scholar 

Naninck EF, Hoeijmakers L, Kakava-Georgiadou N, et al. Chronic early life stress alters developmental and adult neurogenesis and impairs cognitive function in mice. Hippocampus. 2015;25:309–28. https://doi.org/10.1002/hipo.22374.

Article  PubMed  Google Scholar 

Boldrini M, Galfalvy H, Dwork AJ, et al. Resilience is associated with larger dentate gyrus, while suicide decedents with major depressive disorder have fewer granule neurons. Biol Psychiatry. 2019;85:850–62. https://doi.org/10.1016/j.biopsych.2018.12.022.

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