KK reports honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from AbbVie G.K., Novartis Pharma K.K., PharmaEssentia Japan KK, Sanofi K.K., and Takeda Pharmaceutical Co., Ltd. YS reports research funding from Astellas Pharma Inc., Incyte Biosciences Japan G.K., Kyowa Kirin Co., Ltd., Ono Pharmaceutical Co., Ltd., and Toyo Kohan Co., Ltd.; grants from Shojunkai Takeuchi Hospital; honoraria from Novartis Pharma K.K.; and participation on a data safety monitoring board or advisory board for Novartis Pharma K.K. AG reports research funding from Bayer Yakuhin, Ltd., Chugai Pharmaceutical Co., Ltd., Daiichi Sankyo Co., Ltd., Eisai Co., Ltd., MSD K.K., Nihon Pharmaceutical Co., Ltd., Nippon Shinyaku Co., Ltd., Ono Pharmaceutical Co., Ltd., Otsuka Pharmaceutical Co., Ltd., Sumitomo Pharma Co., Ltd., Taiho Pharmaceutical Co., Ltd., and Takeda Pharmaceutical Co., Ltd.; consulting fees from Alexion Pharmaceuticals, Inc., Chugai Pharmaceutical Co., Ltd., and PharmaEssentia Japan KK; honoraria from Alexion Pharmaceuticals, Inc., Chugai Pharmaceutical Co., Ltd., Daiichi Sankyo Co., Ltd., Eisai Co., Ltd., Janssen Pharmaceutical K.K., Kyowa Kirin Co., Ltd., Novartis Pharma K.K., Ono Pharmaceutical Co., Ltd., Otsuka Pharmaceutical Co., Ltd., Nihon Pharmaceutical Co., Ltd., Nippon Shinyaku Co., Ltd., Pfizer Japan Inc., Sanofi K.K., Sumitomo Pharma Co., Ltd., Taiho Pharmaceutical Co., Ltd., and Takeda Pharmaceutical Co., Ltd.; and participation on a data safety monitoring board or advisory board for Alexion Pharmaceuticals, Inc., Chugai Pharmaceutical Co., Ltd., and PharmaEssentia Japan KK. KT reports research funding and consulting fees from Astellas Pharma Inc., Chugai Pharmaceutical Co., Ltd., Kyowa Kirin Co., Ltd., Otsuka Pharmaceutical Co., Ltd., PharmaEssentia Japan KK, and Takeda Pharmaceutical Co., Ltd.; and honoraria from Alexion Pharmaceuticals, Inc., Kyowa Kirin Co., Ltd., MSD K.K., and Novartis Pharma K.K. M Ichii reports payments for presentations from Novartis Pharmaceuticals and payments for speakers bureaus from Sumitomo Pharma Co., Ltd. TI reports payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Asahi Kasei Pharma Co., Ltd., Chugai Pharmaceutical Co., Ltd., Novartis Pharma K.K., and PharmaEssentia Japan KK. SS reports payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from AbbVie G.K., Amgen K.K., Asahi Kasei Pharma Co., Ltd., Novartis Pharma K.K., and Ono Pharmaceutical Co., Ltd. M Ito reports payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from AstraZeneca K.K., Bristol-Myers Squibb K.K., Chugai Pharmaceutical Co., Ltd., Incyte Biosciences Japan G.K., Janssen Pharmaceutical K.K., Novartis Pharma K.K., PharmaEssentia Japan KK, and Takeda Pharmaceutical Co., Ltd. OZ is an employee of PharmaEssentia Corporation USA. AQ is an employee of PharmaEssentia Corporation Taiwan. HK is an employee of PharmaEssentia Japan KK. TS is a board member of PharmaEssentia Japan KK. NK reports grants from Chugai Pharmaceutical Co., Ltd., Kyowa Kirin Co., Ltd., Otsuka Pharmaceutical Co., Ltd., Perseus Proteomics Inc., PharmaEssentia Japan KK, and Sumitomo Pharma Co., Ltd.; research funding from Meiji Seika Pharma Co., Ltd. and Takeda Pharmaceutical Co., Ltd.; consulting fees from Japan Tobacco Inc., PharmaEssentia Japan KK, and Torii Pharmaceutical Co., Ltd.; honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Novartis Pharma K.K. and Takeda Pharmaceutical Co., Ltd.; and is a board member of PharmaEssentia Japan KK. KS reports research funding from AbbVie G.K., Chugai Pharmaceutical Co., Ltd., Daiichi Sankyo Co., Ltd., Eisai Co., Ltd., Kyowa Kirin Co., Ltd., Mochida Pharmaceutical Co., Ltd., Nippon Kayaku Co., Ltd., Otsuka Pharmaceutical Co., Ltd., Shionogi & Co., Ltd., Sumitomo Pharma Co., Ltd., Taisho Pharmaceutical Co., Ltd., and Takeda Pharmaceutical Co., Ltd.; honoraria from Novartis Pharma K.K. and Takeda Pharmaceutical Co., Ltd.; and participation on a data safety monitoring board or advisory board for AbbVie G.K.