Atopic dermatitis in the pediatric population: A cross-sectional, international epidemiologic study. Ann Allergy Asthma Immunol. 2021;126:417-428.e2.

Branum AM, Lukacs SL. Food Allergy Among U.S. Children: Trends in Prevalence and Hospitalizations. NCHS Data Brief. 2008;10:1–7.

Google Scholar 

Ünsal H, Dal ST, Akarsu A, Şahiner ÜM, Soyer Ö, Şekerel BE. Phenotypes of persistent hen`s egg allergy in children and adolescents. Turk J Pediatr. 2023;65. https://doi.org/10.24953/turkjped.2021.5417.

Mahr TA, Lieberman JA, Haselkorn T, Damle V, Ali Y, Chidambaram A, et al. Characteristics of Peanut Allergy Diagnosis in a US Health Care Claims Database (2011–2017). J Allergy Clin Immunol Pract. 2021;9. https://doi.org/10.1016/j.jaip.2020.12.020.

Gupta RS, Springston EE, Warrier MR, Smith B, Kumar R, Pongracic J, et al. The prevalence, severity, and distribution of childhood food allergy in the United States. Pediatrics. 2011;128. https://doi.org/10.1542/peds.2011-0204.

Li JC, Arkin LM, Makhija MM, Singh AM. Prevalence of food allergy diagnosis in pediatric patients with atopic dermatitis referred to allergy and/or dermatology subspecialty clinics. J Allergy Clin Immunol Pract. 2022;10. https://doi.org/10.1016/j.jaip.2022.05.028.

Gabryszewski SJ, Dudley J, Shu D, Faerber JA, Grundmeier RW, Fiks AG, et al. Patterns in the Development of Pediatric Allergy. Pediatrics. 2023;152. https://doi.org/10.1542/peds.2022-060531.

Kroner JW, Kyzy AB, Burkle JW, Martin LJ, LeMasters GK, Bernstein DI, et al. Atopic Dermatitis Independently Increases Sensitization above Parental Atopy: the MPAACH Study. J Allergy Clin Immunol. 2020;145:1464.

Article  PubMed  PubMed Central  Google Scholar 

Christensen MO, Barakji YA, Loft N, Khatib CM, Egeberg A, Thomsen SF, et al. Prevalence of and association between atopic dermatitis and food sensitivity, food allergy and challenge-proven food allergy: A systematic review and meta-analysis. J Eur Acad Dermatol Venereol. 2023;37:984–1003.

Article  CAS  PubMed  Google Scholar 

Akelma Z, Köse SŞ, Özmen S. The risk factors for food allergy in infants with atopic dermatitis. Turk J Pediatr. 2023;65. https://doi.org/10.24953/turkjped.2022.656.

Kawada S, Futamura M, Hashimoto H, Ono M, Akita N, Sekimizu M, et al. Association between sites and severity of eczema and the onset of cow’s milk and egg allergy in children. PLoS One. 2020;15. https://doi.org/10.1371/journal.pone.0240980.

Polaskey MT, Bendelow A, Mukherji J, Buranosky B, Silverberg JI, Fishbein A. Facial atopic dermatitis is associated with sensitization to cow’s milk, egg whites, and peanuts in children under 36 months. Pediatr Dermatol. 2023;40. https://doi.org/10.1111/pde.15326.

McAleer MA, Jakasa I, Raj N, O’Donnell CPF, Lane ME, Rawlings AV, et al. Early-life regional and temporal variation in filaggrin-derived natural moisturizing factor, filaggrin-processing enzyme activity, corneocyte phenotypes and plasmin activity: implications for atopic dermatitis. Br J Dermatol. 2018;179:431–41.

CAS  PubMed  PubMed Central  Google Scholar 

Gabryszewski SJ, Chang X, Dudley JW, Mentch F, March M, Holmes JH, et al. Unsupervised modeling and genome-wide association identify novel features of allergic march trajectories. J Allergy Clin Immunol. 2021;147. https://doi.org/10.1016/j.jaci.2020.06.026.

Jiang J, Warren CM, Brewer A, Soffer G, Gupta RS. Racial, Ethnic, and Socioeconomic Differences in Food Allergies in the US. JAMA Netw Open. 2023;6:e2318162.

Article  PubMed  PubMed Central  Google Scholar 

Brunner PM, Guttman-Yassky E. Racial differences in atopic dermatitis. Ann Allergy Asthma Immunol. 2019;122:449–55.

Article  PubMed  Google Scholar 

Tsilochristou O, du Toit G, Sayre PH, Roberts G, Lawson K, Sever ML, et al. Association of Staphylococcus aureus colonization with food allergy occurs independently of eczema severity. J Allergy Clin Immunol. 2019;144. https://doi.org/10.1016/j.jaci.2019.04.025.

Tham EH, Chia M, Riggioni C, Nagarajan N, Common JEA, Kong HH. The skin microbiome in pediatric atopic dermatitis and food allergy. Allergy. 2024;79:1470–84.

Article  CAS  PubMed  Google Scholar 

Marques-Mejias A, Bartha I, Ciaccio CE, Chinthrajah RS, Chan S, Hershey GKK, et al. Skin as the target for allergy prevention and treatment. Ann Allergy Asthma Immunol. 2024. https://doi.org/10.1016/j.anai.2023.12.030.

Article  PubMed  Google Scholar 

Dębińska A, Sozańska B. Epicutaneous Sensitization and Food Allergy: Preventive Strategies Targeting Skin Barrier Repair-Facts and Challenges. Nutrients. 2023;15. https://doi.org/10.3390/nu15051070.

Lack G. Epidemiologic risks for food allergy. J Allergy Clin Immunol. 2008;121:1331–6.

Article  CAS  PubMed  Google Scholar 

Elias PM, Hatano Y, Williams ML. Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms. J Allergy Clin Immunol. 2008;121:1337–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Geba GP, Li D, Xu M, Mohammadi K, Attre R, Ardeleanu M, et al. Attenuating the atopic march: Meta-analysis of the dupilumab atopic dermatitis database for incident allergic events. J Allergy Clin Immunol. 2023;151:756–66.

Article  CAS  PubMed  Google Scholar 

Leung DYM, Calatroni A, Zaramela LS, LeBeau PK, Dyjack N, Brar K, et al. The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype. Sci Transl Med. 2019;11. https://doi.org/10.1126/scitranslmed.aav2685.

Berdyshev E, Goleva E, Bronova I, Bronoff AS, Hoffman BC, Ramirez-Gama MA, et al. Unique skin abnormality in patients with peanut allergy but no atopic dermatitis. J Allergy Clin Immunol. 2021;147. https://doi.org/10.1016/j.jaci.2020.06.015.

Huffaker MF, Kanchan K, Bahnson HT, Ruczinski I, Shankar G, Leung DYM, et al. Epidermal differentiation complex genetic variation in atopic dermatitis and peanut allergy. J Allergy Clin Immunol. 2023;151. https://doi.org/10.1016/j.jaci.2022.11.008.

Yamada H, Kaitani A, Izawa K, Ando T, Kamei A, Uchida S, et al. Staphylococcus aureus δ-toxin present on skin promotes the development of food allergy in a murine model. Front Immunol. 2023;14. https://doi.org/10.3389/fimmu.2023.1173069.

Packi K, Matysiak J, Klimczak S, Matuszewska E, Bręborowicz A, Pietkiewicz D, et al. Analysis of the Serum Profile of Cytokines Involved in the T-Helper Cell Type 17 Immune Response Pathway in Atopic Children with Food Allergy. Int J Environ Res Public Health. 2022;19. https://doi.org/10.3390/ijerph19137877.

Rizzi A, Lo Presti E, Chini R, Gammeri L, Inchingolo R, Lohmeyer FM, et al. Emerging Role of Alarmins in Food Allergy: An Update on Pathophysiological Insights, Potential Use as Disease Biomarkers, and Therapeutic Implications. J Clin Med Res. 2023;12. https://doi.org/10.3390/jcm12072699.

Hoskinson C, Dai DLY, Del Bel KL, Becker AB, Moraes TJ, Mandhane PJ, et al. Delayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease. Nat Commun. 2023;14. https://doi.org/10.1038/s41467-023-40336-4.

Švigir A, Ljubojević HS, Zrinski TR, Leniček KJ, Pustišek N, Navratil M. Fecal calprotectin as a biomarker of food allergy and disease severity in children with atopic dermatitis without gastrointestinal symptoms. Acta Dermatovenerol Croat. 2021;29. Available: https://pubmed.ncbi.nlm.nih.gov/36896687/. Accessed 12 Mar 2024.

Sampson HA, Aceves S, Bock SA, James J, Jones S, Lang D, et al. Food allergy: a practice parameter update-2014. J Allergy Clin Immunol. 2014;134:1016-25.e43.

Article  PubMed  Google Scholar 

Wollenberg A, Kinberger M, Arents B, Aszodi N, Avila Valle G, Barbarot S, et al. European guideline (EuroGuiDerm) on atopic eczema - part II: non-systemic treatments and treatment recommendations for special AE patient populations. J Eur Acad Dermatol Venereol. 2022;36:1904–26.

Article  CAS  PubMed  Google Scholar 

Rokaite R, Labanauskas L, Vaideliene L. Role of the skin patch test in diagnosing food allergy in children with atopic dermatitis. Medicina. 2004;40. Available: https://pubmed.ncbi.nlm.nih.gov/15547309/. Accessed 8 June 2024.

Du Toit G, Roberts G, Sayre PH, Bahnson HT, Radulovic S, Santos AF, et al. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med. 2015;372. https://doi.org/10.1056/NEJMoa1414850.

Fisher HR, Du Toit G, Bahnson HT, Lack G. The challenges of preventing food allergy: Lessons learned from LEAP and EAT. Ann Allergy Asthma Immunol. 2018;121:313–9.

Article  PubMed  Google Scholar 

Perkin MR, Logan K, Bahnson HT, Marrs T, Radulovic S, Craven J, et al. Efficacy of the Enquiring About Tolerance (EAT) study among infants at high risk of developing food allergy. J Allergy Clin Immunol. 2019;144:1606-1614.e2.

Article  PubMed  PubMed Central  Google Scholar 

Togias A, Cooper SF, Acebal ML, Assa’ad A, Baker JR Jr, Beck LA, et al. Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel. J Allergy Clin Immunol. 2017;139:29–44.

Soriano VX, Peters RL, Ponsonby A-L, Dharmage SC, Perrett KP, Field MJ, et al. Earlier ingestion of peanut after changes to infant feeding guidelines: The EarlyNuts study. J Allergy Clin Immunol. 2019;144:1327-1335.e5.

Article  PubMed  Google Scholar 

Fleischer DM, Chan ES, Venter C, Spergel JM, Abrams EM, Stukus D, et al. A Consensus Approach to the Primary Prevention of Food Allergy Through Nutrition: Guidance from the American Academy of Allergy, Asthma, and Immunology; American College of Allergy, Asthma, and Immunology; and the Canadian Society for Allergy and Clinical Immunology. J Allergy Clin Immunol Pract. 2021;9:22-43.e4.

Article  CAS  PubMed  Google Scholar 

Horimukai K, Morita K, Narita M, Kondo M, Kitazawa H, Nozaki M, et al. Application of moisturizer to neonates prevents development of atopic dermatitis. J Allergy Clin Immunol. 2014;134:824-830.e6.

Article  PubMed  Google Scholar 

Skjerven HO, Lie A, Vettukattil R, Rehbinder EM, LeBlanc M, Asarnoj A, et al. Early food intervention and skin emollients to prevent food allergy in young children (PreventADALL): a factorial, multicentre, cluster-randomised trial. Lancet. 2022;399:2398–411.

Article  PubMed  Google Scholar 

Chalmers JR, Haines RH, Bradshaw LE, Montgomery AA, Thomas KS, Brown SJ, et al. Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial. Lancet. 2020;395:962–72.

Article  PubMed  PubMed Central  Google Scholar 

Lowe AJ, Su JC, Allen KJ, Abramson MJ, Cranswick N, Robertson CF, et al. A randomized trial of a barrier lipid replacement strategy for the prevention of atopic dermatitis and allergic sensitization: the PEBBLES pilot study. Br J Dermatol. 2018;178:e19–21.

Article  CAS  PubMed  Google Scholar 

AAAAI/ACAAI JTF Atopic Dermatitis Guideline Panel, Chu DK, Schneider L, Asiniwasis RN, Boguniewicz M, De Benedetto A, et al. Atopic dermatitis (eczema) guidelines: 2023 American Academy of Allergy, Asthma and Immunology/American College of Allergy, Asthma and Immunology Joint Task Force on Practice Parameters GRADE- and Institute of Medicine-based recommendations. Ann Allergy Asthma Immunol. 2024;132: 274–312.

Miyaji Y, Yang L, Yamamoto-Hanada K, Narita M, Saito H, Ohya Y. Earlier aggressive treatment to shorten the duration of eczema in infants resulted in fewer food allergies at 2 years of age. J Allergy Clin Immunol Pract. 2020;8. https://doi.org/10.1016/j.jaip.2019.11.036.

Murashkin NN, Namazova-Baranova LS, Makarova SG, Ivanov RA, Grigorev SG, Fedorov DV, et al. Observational study of pimecrolimus 1% cream for prevention of transcutaneous sensitization in children with atopic dermatitis during their first year of life. Front Pediatr. 2023;11:1102354.

Article  PubMed  PubMed Central  Google Scholar 

Schneider L, Hanifin J, Boguniewicz M, Eichenfield LF, Spergel JM, Dakovic R, et al. Study of the Atopic March: Development of Atopic Comorbidities. Pediatr Dermatol. 2016;33:388–98.

Article  PubMed  PubMed Central  Google Scholar 

Yamamoto-Hanada K, Kobayashi T, Mikami M, Williams HC, Saito H, Saito-Abe M, et al. Enhanced early skin treatment for atopic dermatitis in infants reduces food allergy. J Allergy Clin Immunol. 2023;152. https://doi.org/10.1016/j.jaci.2023.03.008.

Logan K, Bahnson HT, Ylescupidez A, Beyer K, Bellach J, Campbell DE, et al. Early introduction of peanut reduces peanut allergy across risk groups in pooled and causal inference analyses. Allergy. 2023;78:1307–18.

Article  PubMed