Fuller, R. et al. Pollution and health: a progress update. Lancet Planet Health 6, e535–e547 (2022).

Article  PubMed  Google Scholar 

Landrigan, P. J. et al. The Lancet Commission on Pollution and Health. Lancet 391, 462–512 (2018).

Article  PubMed  Google Scholar 

Munzel, T., Hahad, O., Daiber, A. & Landrigan, P. J. Soil and water pollution and human health: what should cardiologists worry about? Cardiovasc. Res. 119, 440–449 (2023).

Article  PubMed  Google Scholar 

GBD 2015 DALYs and HALE Collaborators Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 388, 1603–1658 (2016).

Article  Google Scholar 

Institute for Health Metrics and Evaluation. Global health data exchange tool. Global Health Data Exchange http://ghdx.healthdata.org/gbd-results-tool (2023).

Lelieveld, J. et al. Cardiovascular disease burden from ambient air pollution in Europe reassessed using novel hazard ratio functions. Eur. Heart J. 40, 1590–1596 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lelieveld, J. et al. Air pollution deaths attributable to fossil fuels: observational and modelling study. BMJ 383, e077784 (2023).

Article  PubMed  PubMed Central  Google Scholar 

World Health Organization. The public health impact of chemicals: knowns and unknowns – data addendum for 2019. WHO https://www.who.int/publications/i/item/WHO-HEP-ECH-EHD-21.01 (2021).

World Health Organization. Global action plan for the prevention and control of non-communicable diseases 2013–2020. WHO https://www.who.int/publications/i/item/9789241506236 (2013).

United Nations Environment Program. Global assessment of soil pollution. UNEP https://www.unep.org/resources/report/global-assessment-soil-pollution (2021).

United Nations Environment Program. Soil pollution a risk to our health and food security. UNEP https://www.unep.org/news-and-stories/story/soil-pollution-risk-our-health-and-food-security (2020).

Mielke, H. W. & Reagan, P. L. Soil is an important pathway of human lead exposure. Environ. Health Perspect. 106, 217–229 (1998).

CAS  PubMed  PubMed Central  Google Scholar 

European Envrionment Agency. Water Pollution and Health. EEA https://www.eea.europa.eu/publications/zero-pollution/health/water-pollution (2022).

United Nations. Water. summary progress update 2021: SDG 6 – Water and sanitation for all. UN-Water http://www.unwater.org/sites/default/files/app/uploads/2021/12/SDG-6-Summary-Progress-Update-2021_Version-July-2021a.pdf (2021).

Global Allliance on Health and Pollution. Pollution and health metrics. GAHP https://gahp.net/wp-content/uploads/2019/12/PollutionandHealthMetrics-final-12_18_2019.pdf (2019).

World Health Organization. The public health impact of chemicals: knowns and unknowns. WHO http://www.who.int/publications/i/item/WHO-FWC-PHE-EPE-16.01-eng (2016).

World Health Organization. Food safety. WHO http://www.who.int/news-room/fact-sheets/detail/food-safety (2022).

European Commission. The European Human Biomonitoring Initiative. HBM4EU https://www.hbm4eu.eu/ (2016).

Centers for Disease Control and Prevention. National biomonitoring program. CDC https://www.cdc.gov/biomonitoring/index.html (2018).

Persson, L. et al. Outside the safe operating space of the planetary boundary for novel entities. Environ. Sci. Technol. 56, 1510–1521 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

United Nations Environment Program. Global chemicals outlook II – from legacies to innovative solutions: Implementing the 2030 Agenda for Sustainable Development (Part I). UNEP https://www.unep.org/topics/chemicals-and-pollution-action/chemicals-management/global-chemicals-outlook (2019).

Maertens, A., Golden, E. & Hartung, T. Avoiding regrettable substitutions: green toxicology for sustainable chemistry. ACS Sustain. Chem. Eng. 9, 7749–7758 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peters, A., Nawrot, T. S. & Baccarelli, A. A. Hallmarks of environmental insults. Cell 184, 1455–1468 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

La Merrill, M. A. et al. Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification. Nat. Rev. Endocrinol. 16, 45–57 (2020).

Article  PubMed  Google Scholar 

Cosselman, K. E., Navas-Acien, A. & Kaufman, J. D. Environmental factors in cardiovascular disease. Nat. Rev. Cardiol. 12, 627–642 (2015).

Article  CAS  PubMed  Google Scholar 

Liu, Z., Lu, Y., Zhong, K., Wang, C. & Xu, X. The associations between endocrine disrupting chemicals and markers of inflammation and immune responses: a systematic review and meta-analysis. Ecotoxicol. Environ. Saf. 234, 113382 (2022).

Article  CAS  PubMed  Google Scholar 

Chen, J. C. et al. Associations of per- and polyfluoroalkyl substances, polychlorinated biphenyls, organochlorine pesticides, and polybrominated diphenyl ethers with oxidative stress markers: a systematic review and meta-analysis. Environ. Res. 239, 117308 (2023).

Article  CAS  PubMed  Google Scholar 

Daiber, A. et al. Targeting vascular (endothelial) dysfunction. Br. J. Pharmacol. 174, 1591–1619 (2017).

Article  CAS  PubMed  Google Scholar 

Wenzel, P., Kossmann, S., Munzel, T. & Daiber, A. Redox regulation of cardiovascular inflammation – immunomodulatory function of mitochondrial and Nox-derived reactive oxygen and nitrogen species. Free Radic. Biol. Med. 109, 48–60 (2017).

Article  CAS  PubMed  Google Scholar 

Vogel, C. F. A., Van Winkle, L. S., Esser, C. & Haarmann-Stemmann, T. The aryl hydrocarbon receptor as a target of environmental stressors – implications for pollution mediated stress and inflammatory responses. Redox Biol. 34, 101530 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martinez-Pinna, J. et al. Endocrine disruptors in plastics alter β-cell physiology and increase the risk of diabetes mellitus. Am. J. Physiol. Endocrinol. Metab. 324, E488–E505 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sule, R. O., Condon, L. & Gomes, A. V. A common feature of pesticides: oxidative stress – the role of oxidative stress in pesticide-induced toxicity. Oxid. Med. Cell Longev. 2022, 5563759 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Rasin, P. & Sreekanth, A. Cadmium exposure and cardiovascular diseases. Chem. Res. Toxicol. 36, 1441–1443 (2023).

Article  CAS  PubMed  Google Scholar 

Singh, N., Kumar, A., Gupta, V. K. & Sharma, B. Biochemical and molecular bases of lead-induced toxicity in mammalian systems and possible mitigations. Chem. Res. Toxicol. 31, 1009–1021 (2018).

Article  CAS  PubMed  Google Scholar 

Hu, H., Chen, Y., Jing, L., Zhai, C. & Shen, L. The link between ferroptosis and cardiovascular diseases: a novel target for treatment. Front. Cardiovasc. Med. 8, 710963 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Farina, M., Aschner, M. & Rocha, J. B. Oxidative stress in MeHg-induced neurotoxicity. Toxicol. Appl. Pharmacol. 256, 405–417 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kempuraj, D. et al. Mercury induces inflammatory mediator release from human mast cells. J. Neuroinflammation 7, 20 (2010).

Article  PubMed  PubMed Central  Google Scholar 

Ellinsworth, D. C. Arsenic, reactive oxygen, and endothelial dysfunction. J. Pharmacol. Exp. Ther. 353, 458–464 (2015).

Article  CAS  PubMed  Google Scholar 

Jomova, K. & Valko, M. Advances in metal-induced oxidative stress and human disease. Toxicology 283, 65–87 (2011).

Article  CAS  PubMed  Google Scholar 

Gaetke, L. M. & Chow, C. K. Copper toxicity, oxidative stress, and antioxidant nutrients. Toxicology 189, 147–163 (2003).

Article  CAS