Byrne C, Caskey F, Castledine C, et al. UK Renal Registry. Nephron. 2018;139.
Koye DN, Shaw JE, Reid CM et al (2017) Incidence of chronic kidney disease among people with diabetes: a systematic review of observational studies. Diabet Med 34:887–901
Article CAS PubMed Google Scholar
Fineberg D, Jandeleit-Dahm KAM, Cooper ME (2013) Diabetic nephropathy: diagnosis and treatment. Nat Rev Endocrinol 9:713–723
Article CAS PubMed Google Scholar
Selby NM, Taal MW (2020) An updated overview of diabetic nephropathy: diagnosis, prognosis, treatment goals and latest guidelines. Diabetes, Obes Metab 22:3–15
Wendt TM, Tanji N, Guo J et al (2003) RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy. Am J Pathol 162:1123–1137
Article CAS PubMed PubMed Central Google Scholar
Coughlan MT, Thorburn DR, Penfold SA et al (2009) RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes. J Am Soc Nephrol JASN 20:742
Article CAS PubMed Google Scholar
Nagata M (2016) Podocyte injury and its consequences. Kidney Int 89:1221–1230
Article CAS PubMed Google Scholar
Barutta F, Bellini S, Gruden G (2022) Mechanisms of podocyte injury and implications for diabetic nephropathy. Clin Sci 136:493–520
Sarafidis PA, Lasaridis AN (2010) Endothelin antagonism for diabetic nephropathy. Nat Rev Nephrol 6:447–449
Article CAS PubMed Google Scholar
Asanuma K, Mundel P (2003) The role of podocytes in glomerular pathobiology. J Clin Exp Nephrol 7:255–259
Empitu MA, Kikyo M, Shirata N et al (2023) Inhibition of importin-a–mediated nuclear localization of dendrin attenuates podocyte loss and glomerulosclerosis. J Am Soc Nephrol 34:1222–1239
Article PubMed PubMed Central Google Scholar
Empitu MA, Kadariswantiningsih IN, Aizawa M et al (2018) MAGI-2 and scaffold proteins in glomerulopathy. Am J Physiol Physiol 315:F1336–F1344
Lenoir O, Milon M, Virsolvy A et al (2014) Direct action of endothelin-1 on podocytes promotes diabetic glomerulosclerosis. J Am Soc Nephrol JASN 25:1050
Article CAS PubMed Google Scholar
Du P, Fan B, Han H et al (2013) NOD2 promotes renal injury by exacerbating inflammation and podocyte insulin resistance in diabetic nephropathy. Kidney Int 84:265–276
Article CAS PubMed Google Scholar
Tagawa A, Yasuda M, Kume S et al (2016) Impaired podocyte autophagy exacerbates proteinuria in diabetic nephropathy. Diabetes 65:755–767
Article CAS PubMed Google Scholar
Cybulsky AV (2017) Endoplasmic reticulum stress, the unfolded protein response and autophagy in kidney diseases. Nat Rev Nephrol 13:681–696
Article CAS PubMed Google Scholar
Barton M, Yanagisawa M (2019) Endothelin: 30 years from discovery to therapy. Hypertension 74:1232–1265
Article CAS PubMed Google Scholar
Yanagisawa M, Kurihara H, Kimura S et al (1988) A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nat 332:411–415
Ko CM, Gieske MC, Al-Alem L et al (2006) Endothelin-2 in ovarian follicle rupture. Endocrinology 147:1770–1779
Article CAS PubMed Google Scholar
Chang I, Bramall AN, Baynash AG et al (2013) Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest 123:2643–2653
Article CAS PubMed PubMed Central Google Scholar
Kurihara Y, Kurihara H, Suzuki H, et al. Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1. Nat 1994 3686473. 1994;368:703–10.
McPherson A, Larson SB (2019) The X-ray crystal structure of human endothelin 1, a polypeptide hormone regulator of blood pressure. Acta Crystallogr Sect F Struct Biol Commun 75:47–53
Davenport AP, Hyndman KA, Dhaun N et al (2016) Endothelin. Pharmacol Rev 68(2):357–418
Article PubMed PubMed Central Google Scholar
Huggins JP, Pelton JT, Miller RC (1993) The structure and specificity of endothelin receptors: their importance in physiology and medicine. Pharmacol Ther 59:55–123
Article CAS PubMed Google Scholar
Williams DL, Jones KL, Pettibone DJ et al (1991) Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes. Biochem Biophys Res Commun 175:556–561
Article CAS PubMed Google Scholar
Maguire JJ, Davenport AP (1999) Endothelin receptor expression and pharmacology in human saphenous vein graft. Br J Pharmacol 126:443
Article CAS PubMed PubMed Central Google Scholar
Clouthier DE, Hosoda K, Richardson JA et al (1998) Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice. Development 125:813–824
Article CAS PubMed Google Scholar
Hosoda K, Hammer RE, Richardson JA et al (1994) Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice. Cell 79:1267–1276
Article CAS PubMed Google Scholar
Speck D, Kleinau G, Szczepek M et al (2022) Angiotensin and endothelin receptor structures with implications for signaling regulation and pharmacological targeting. Front Endocrinol (Lausanne). https://doi.org/10.3389/FENDO.2022.880002/FULL
Vachiéry JL, Davenport A (2009) The endothelin system in pulmonary and renal vasculopathy: les liaisons dangereuses. Eur Respir Rev 18:260–271
Maguire JJ, Davenport AP (2015) Endothelin receptors and their antagonists. Semin Nephrol 35:125–136
Article CAS PubMed PubMed Central Google Scholar
Bremnes T, Paasche JD, Mehlum A et al (2000) Regulation and intracellular trafficking pathways of the endothelin receptors. J Biol Chem 275:17596–17604
Article CAS PubMed Google Scholar
Nambi P, Pullen M, Wu H-L et al (1992) Identification of endothelin receptor subtypes in human renal cortex and medulla using subtype-selective ligands. Endocrinology 131:1081–1086
Article CAS PubMed Google Scholar
Kuc R, Davenport AP (2004) Comparison of endothelin-A and endothelin-B receptor distribution visualized by radioligand binding versus immunocytochemical localization using subtype selective antisera. J Cardiovasc Pharmacol 44:S224–S226
Article CAS PubMed Google Scholar
Buelli S, Rosanò L, Gagliardini E et al (2014) β-Arrestin-1 drives endothe
留言 (0)