Brunt E, Aishima S, Clavien PA, et al. cHCC-CCA: consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentiation. Hepatology. 2018;68:113–126

Article  PubMed  Google Scholar 

Sciarra A, Park YN, Sempoux C. Updates in the diagnosis of combined hepatocellular-cholangiocarcinoma. Hum Pathol. 2020;96:48–55

Article  CAS  PubMed  Google Scholar 

Shetty AS, Fowler KJ, Brunt EM, Agarwal S, Narra VR, Menias CO. Combined hepatocellular-cholangiocarcinoma: what the radiologist needs to know about biphenotypic liver carcinoma. Abdom Imaging. 2014;39:310–322

Article  PubMed  Google Scholar 

Groeschl RT, Turaga KK, Gamblin TC. Transplantation versus resection for patients with combined hepatocellular carcinoma-cholangiocarcinoma. J Surg Oncol. 2013;107:608–612

Article  PubMed  Google Scholar 

Gera S, Ettel M, Acosta-Gonzalez G, Xu R. Clinical features, histology, and histogenesis of combined hepatocellular-cholangiocarcinoma. World J Hepatol. 2017;9:300–309

Article  PubMed  PubMed Central  Google Scholar 

Wu CH, Yong CC, Liew EH, et al. Combined hepatocellular carcinoma and cholangiocarcinoma: diagnosis and prognosis after resection or transplantation. Transplant Proc. 2016;48:1100–1104

Article  PubMed  Google Scholar 

Jung DH, Hwang S, Song GW, et al. Longterm prognosis of combined hepatocellular carcinoma-cholangiocarcinoma following liver transplantation and resection. Liver Transpl. 2017;23:330–341

Article  PubMed  Google Scholar 

Fowler KJ, Sheybani A, Parker RA, et al. Combined hepatocellular and cholangiocarcinoma (biphenotypic) tumors: imaging features and diagnostic accuracy of contrast-enhanced CT and MRI. AJR Am J Roentgenol. 2013;201:332–339

Article  PubMed  Google Scholar 

Zhou CW, Wang Y, Ma L, Qian XL, Yang C, Zeng MS. Combined hepatocellular carcinoma-cholangiocarcinoma: MRI features correlated with tumor biomarkers and prognosis. Eur Radiol. 2022;32:78–88

Article  CAS  PubMed  Google Scholar 

Nagtegaal ID, Odze RD, Klimstra D, et al. The 2019 WHO classification of tumours of the digestive system. Histopathology. 2020;76:182–188

Article  PubMed  Google Scholar 

Sempoux C, Kakar S, Kondo F, Schirmacher P. Combined hepatocellular-cholangiocarcinoma and undifferentiated primary liver carcinoma. WHO classification of tumours: digestive system tumours, 5th edition. France: Lyon IARC. 2019. pp. 260–262

Lee JH, Chung GE, Yu SJ, et al. Long-term prognosis of combined hepatocellular and cholangiocarcinoma after curative resection comparison with hepatocellular carcinoma and cholangiocarcinoma. J Clin Gastroenterol. 2011;45:69–75

Article  PubMed  Google Scholar 

Yin X, Zhang BH, Qiu SJ, et al. Combined hepatocellular carcinoma and cholangiocarcinoma: clinical features, treatment modalities, and prognosis. Ann Surg Oncol. 2012;19:2869–2876

Article  PubMed  Google Scholar 

Yoon YI, Hwang S, Lee YJ, et al. Postresection outcomes of combined hepatocellular carcinoma-cholangiocarcinoma, hepatocellular carcinoma and intrahepatic cholangiocarcinoma. J Gastrointest Surg. 2016;20:411–420

Article  PubMed  Google Scholar 

Wang XL, Wang WT, Ma XJ, et al. lCombined hepatocellular-cholangiocarcinoma: which preoperative clinical data and conventional MRI characteristics have value for the prediction of microvascular invasion and clinical significance? Eur Radiol. 2020;30:5337–5347

Article  PubMed  PubMed Central  Google Scholar 

Jiang XX, Huang XT, Huang CS, Chen LH, Liang LJ, Yin XY. Long-term outcome and prognostic factors of combined hepatocellular carcinoma and cholangiocarcinoma after curative resection. Gastroenterol Rep. 2020;8:134–142

Article  Google Scholar 

Zhou CW, Ni XY, Lu X, et al. MR features based on LI-RADS ver. correlated with cytokeratin 19 expression in combined hepatocellular carcinoma-cholangiocarcinoma. J Hepatocell Carcino. 2018;2021(8):975–983

Google Scholar 

Chernyak V, Fowler KJ, Kamaya A, et al. Liver imaging reporting and data system (LI-RADS) version 2018: imaging of hepatocellular carcinoma in at-risk patients. Radiology. 2018;289:816–830

Article  PubMed  Google Scholar 

Saraiya N, Yopp AC, Rich NE, Odewole M, Parikh ND, Singal AG. Systematic review with meta-analysis: recurrence of hepatocellular carcinoma following direct-acting antiviral therapy. Aliment Pharmacol Ther. 2018;48:127–137

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bridgewater J, Galle PR, Khan SA, et al. Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma. J Hepatol. 2014;60:1268–1289

Article  PubMed  Google Scholar 

He C, Mao Y, Wang J, et al. The predictive value of staging systems and inflammation scores for patients with combined hepatocellular cholangiocarcinoma after surgical resection: a retrospective study. J Gastrointest Surg. 2018;22:1239–1250

Article  PubMed  Google Scholar 

Choi SH, Lee SS, Park SH, et al. LI-RADS classification and prognosis of primary liver cancers at gadoxetic acid-enhanced MRI. Radiology. 2019;290:388–397

Article  PubMed  Google Scholar 

Jeon SK, Joo I, Lee DH, et al. Combined hepatocellular cholangiocarcinoma: LI-RADS v2017 categorisation for differential diagnosis and prognostication on gadoxetic acid-enhanced MR imaging. Eur Radiol. 2019;29:373–382

Article  PubMed  Google Scholar 

Park SH, Lee SS, Yu E, et al. Combined hepatocellular-cholangiocarcinoma: gadoxetic acid-enhanced MRI findings correlated with pathologic features and prognosis. J Magn Reson Imaging. 2017;46:267–280

Article  PubMed  Google Scholar 

Choi SH, Jeon SK, Lee SS, et al. Radio-pathologic correlation of biphenotypic primary liver cancer (combined hepatocellular cholangiocarcinoma): changes in the 2019 WHO classification and impact on LI-RADS classification at liver MRI. Eur Radiol. 2021;31:9479–9488

Article  PubMed  Google Scholar 

Choi JY, Lee JM, Sirlin CB. CT and MR imaging diagnosis and staging of hepatocellular carcinoma: part II. Extracellular agents, hepatobiliary agents, and ancillary imaging features. Radiology. 2014;273:30–50

Article  PubMed  Google Scholar 

Li D, Si X, Wang S, Zhou Y. Long-term outcomes of combined hepatocellular-cholangiocarcinoma after hepatectomy or liver transplantation: A systematic review and meta-analysis. Hepatobiliary Pancreat Dis Int. 2019;18:12–18

Article  PubMed  Google Scholar 

Magistri P, Tarantino G, Serra V, Guidetti C, Ballarin R, Di F. Liver transplantation and combined hepatocellular-cholangiocarcinoma: feasibility and outcomes. Dig Liver Dis. 2017;49:467–470

Article  PubMed  Google Scholar 

Kim M, Hwang S, Song G, et al. Salvage living donor liver transplantation for post-resection recurrence of combined hepatocellular carcinoma-cholangiocarcinoma. Korean J Transplant. 2021;35:116–123

Article  PubMed  PubMed Central  Google Scholar