In patients who are undergoing transcatheter aortic valve implantation (TAVI) for severe aortic stenosis and who have stable coronary artery disease (CAD), percutaneous coronary intervention (PCI) reduces the occurrence of major adverse cardiac events compared with conservative treatment. This finding from the NOTION-3 trial was presented at the ESC Congress 2024.

Aortic stenosis and CAD have shared risk factors, aetiology and clinical presentation. Approximately 50% of patients undergoing TAVI also have CAD. However, no clear recommendation exists in European or US guidelines on performing PCI in addition to TAVI.