Aharoni-Simon M, Hann-Obercyger M, Pen S, Madar Z, Tirosh O (2011) Fatty liver is associated with impaired activity of PPARγ-coactivator 1α (PGC1α) and mitochondrial biogenesis in mice. Lab Invest 91:1018–1028

Article  PubMed  CAS  Google Scholar 

Alam MF, Safhi MM, Anwer T, Siddiqui R, Khan G, Moni SS (2018) Therapeutic potential of Vanillylacetone against CCl4 induced hepatotoxicity by suppressing the serum marker, oxidative stress, inflammatory cytokines and apoptosis in Swiss albino mice. Exp Mol Pathol 105:81–88

Article  PubMed  CAS  Google Scholar 

Bedoui A, Mufti A, Feriani A, Baccari H, Bouallegue A, Kharrat M, Sobeh M, Amri M, Abbes Z (2023) Unlocking the hepatoprotective potential of the parasitic plant Orobanche foetida Poir. aqueous extract against CCl(4)-induced liver injury in rat. Front Pharmacol 14:1320062

Article  PubMed  CAS  Google Scholar 

Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–254

Article  PubMed  CAS  Google Scholar 

Chang SN, Kim SH, Dey DK, Park SM, Nasif O, Bajpai VK, Kang SC, Lee J, Park JG (2021) 5-O-Demethylnobiletin alleviates CCl4-induced acute liver injury by equilibrating ROS-mediated apoptosis and autophagy induction. Int J Mol Sci 22(3):1083

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chiu Y-J, Chou S-C, Chiu C-S, Kao C-P, Wu K-C, Chen C-J, Tsai J-C, Peng W-H (2018) Hepatoprotective effect of the ethanol extract of Polygonum orientale on carbon tetrachloride-induced acute liver injury in mice. J Food Drug Anal 26:369–379

Article  PubMed  CAS  Google Scholar 

Dong B (2018) Protective effects of sinomenine against ankylosing spondylitis and the underlying molecular mechanisms. Med Sci Monit 24:3631–3636

Article  PubMed  PubMed Central  CAS  Google Scholar 

Du K, Ramachandran A, McGill MR, Mansouri A, Asselah T, Farhood A, Woolbright BL, Ding WX, Jaeschke H (2017) Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity. Food Chem Toxicol 108:339–350

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fan H, Tu T, Zhang X, Yang Q, Liu G, Zhang T, Bao Y, Lu Y, Dong Z, Dong J, Zhao P (2022) Sinomenine attenuates alcohol-induced acute liver injury via inhibiting oxidative stress, inflammation and apoptosis in mice. Food Chem Toxicol 159:112759

Article  PubMed  CAS  Google Scholar 

Fu C, Wang Q, Zhai X, Gao J (2018) Sinomenine reduces neuronal cell apoptosis in mice after traumatic brain injury via its effect on mitochondrial pathway. Drug Des Devel Ther 12:77–84

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gao T, Shi T, Wiesenfeld-Hallin Z, Svensson CI, Xu X-J (2015) Sinomenine alleviates mechanical hypersensitivity in mice with experimentally induced rheumatoid arthritis. Scand J Pain 7:9–14

Article  PubMed  Google Scholar 

Hui B, Shu Y, Yang D, Wang Z, Zhang L, Lei N, Yang Z (2022) Sinomenine pretreatment alleviates hepatic ischemia/reperfusion injury through activating Nrf-2/HO-1 pathway. Immun Inflamm Dis 10:e700

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jamwal S, Blackburn JK, Elsworth JD (2021) PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders. Pharmacol Ther 219:107705

Article  PubMed  CAS  Google Scholar 

Jeong TB, Kwon D, Son SW, Kim SH, Lee YH, Seo MS, Kim KS, Jung YS (2020) Weaning mice and adult mice exhibit differential carbon tetrachloride-induced acute hepatotoxicity. Antioxidants (Basel) 9(3):201

Article  PubMed  CAS  Google Scholar 

Kayalı A, Bora ES, Acar H, Erbaş O (2024) Evaluation of the reparative effect of sinomenine in an acetaminophen-induced liver injury model. Curr Issues Mol Biol 46:923–933

Article  PubMed  PubMed Central  Google Scholar 

Komen JC, Thorburn DR (2014) Turn up the power - pharmacological activation of mitochondrial biogenesis in mouse models. Br J Pharmacol 171:1818–1836

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lee G-H, Lee H-Y, Choi M-K, Chung H-W, Kim S-W, Chae H-J (2017) Protective effect of Curcuma longa L. extract on CCl4-induced acute hepatic stress. BMC Res Notes 10:77

Article  PubMed  PubMed Central  Google Scholar 

Li R, Yang W, Yin Y, Ma X, Zhang P, Tao K (2021) 4-OI Attenuates carbon tetrachloride-induced hepatic injury via regulating oxidative stress and the inflammatory response. Front Pharmacol 12:651444

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li Y, Cai W, Ai Z, Xue C, Cao R, Dong N (2023) Protective effects of sinomenine hydrochloride on lead-induced oxidative stress, inflammation, and apoptosis in mouse liver. Environ Sci Pollut Res Int 30:7510–7521

Article  PubMed  CAS  Google Scholar 

Lin S-Y, Xu D, Du X-X, Ran C-L, Xu L, Ren S-J, Tang Z-T, Yin L-Z, He C-L, Yuan Z-X, Fu H-L, Zhao X-L, Shu G (2019) Protective effects of salidroside against carbon tetrachloride (CCl4)-induced liver injury by initiating mitochondria to resist oxidative stress in mice. Int J Mol Sci 20:3187

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu S, Chen Q, Liu J, Yang X, Zhang Y, Huang F (2018) Sinomenine protects against E.coli-induced acute lung injury in mice through Nrf2-NF-κB pathway. Biomed Pharmacother 107:696–702

Article  PubMed  CAS  Google Scholar 

Ma Y, Li W, Yao Q, Liu Y, Yu J, Zang L, Wang S, Zhou L, Wen S, Luo Y, Li W, Niu X (2024) Harmine ameliorates CCl(4)-induced acute liver injury through suppression of autophagy and inflammation. Int Immunopharmacol 129:111538

Article  PubMed  CAS  Google Scholar 

Mohi-Ud-Din R, Mir RH, Sawhney G, Dar MA, Bhat ZA (2019) Possible pathways of hepatotoxicity caused by chemical agents. Curr Drug Metab 20:867–879

Article  PubMed  CAS  Google Scholar 

Movsesyan VA, Yakovlev AG, Dabaghyan EA, Stoica BA, Faden AI (2002) Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway. Biochem Biophys Res Commun 299:201–207

Article  PubMed  CAS  Google Scholar 

Nwaechefu OO, Olaolu TD, Akinwunmi IR, Ojezele OO, Olorunsogo OO (2022) Cajanus cajan ameliorated CCl4-induced oxidative stress in Wistar rats via the combined mechanisms of anti-inflammation and mitochondrial-membrane transition pore inhibition. J Ethnopharmacol 289:114920

Article  PubMed  CAS  Google Scholar 

Rostami A, Taleahmad F, Haddadzadeh-Niri N, Joneidi E, Afshin-Majd S, Baluchnejadmojarad T, Roghani M (2022) Sinomenine attenuates trimethyltin-induced cognitive decline via targeting hippocampal oxidative stress and neuroinflammation. J Mol Neurosci 72:1609–1621

Article  PubMed  CAS  Google Scholar 

Rousta AM, Mirahmadi SM, Shahmohammadi A, Mehrabi Z, Fallah S, Baluchnejadmojarad T, Roghani M (2022) Therapeutic potential of isorhamnetin following acetaminophen-induced hepatotoxicity through targeting NLRP3/NF-κB/Nrf2. Drug Res (Stuttg) 72:245–254

Article  PubMed  CAS  Google Scholar 

Stravitz RT, Lee WM (2019) Acute liver failure. Lancet 394:869–881

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ullah H, Khan A, Baig MW, Ullah N, Ahmed N, Tipu MK, Ali H, Khan S (2020) Poncirin attenuates CCL4-induced liver injury through inhibition of oxidative stress and inflammatory cytokines in mice. BMC Complement Med Ther 20:115