Cabeza-Cabrerizo, M., Cardoso, A., Minutti, C. M., Pereira da Costa, M. & Reis e Sousa, C. Dendritic cells revisited. Annu. Rev. Immunol. 39, 131–166 (2021). This recent review nicely summarizes the latest insights on DC nomenclature, ontogeny and function.

Article  CAS  PubMed  Google Scholar 

Durai, V. & Murphy, K. M. Functions of murine dendritic cells. Immunity 45, 719–736 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eisenbarth, S. C. Dendritic cell subsets in T cell programming: location dictates function. Nat. Rev. Immunol. 19, 89–103 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mildner, A. & Jung, S. Development and function of dendritic cell subsets. Immunity 40, 642–656 (2014).

Article  CAS  PubMed  Google Scholar 

Ziegler-Heitbrock, L., Ohteki, T., Ginhoux, F., Shortman, K. & Spits, H. Reclassifying plasmacytoid dendritic cells as innate lymphocytes. Nat. Rev. Immunol. https://doi.org/10.1038/s41577-022-00806-0 (2023).

Reizis, B. et al. Reclassification of plasmacytoid dendritic cells as innate lymphocytes is premature. Nat. Rev. Immunol. 23, 336–337 (2023).

Article  CAS  PubMed  Google Scholar 

Ziegler-Heitbrock, L., Ohteki, T., Ginhoux, F., Shortman, K. & Spits, H. Reply to ‘Reclassification of plasmacytoid dendritic cells as innate lymphocytes is premature’. Nat. Rev. Immunol. 23, 338–339 (2023).

Article  CAS  PubMed  Google Scholar 

Schlitzer, A. et al. Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow. Nat. Immunol. 16, 718–728 (2015).

Article  CAS  PubMed  Google Scholar 

Feng, J. et al. Clonal lineage tracing reveals shared origin of conventional and plasmacytoid dendritic cells. Immunity 55, 405–422.e11 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guilliams, M. et al. Unsupervised high-dimensional analysis aligns dendritic cells across tissues and species. Immunity 45, 669–684 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guilliams, M. et al. Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny. Nat. Rev. Immunol. 14, 571–578 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Geissmann, F. et al. Development of monocytes, macrophages, and dendritic cells. Science 327, 656–661 (2010).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lewis, K. L. et al. Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Immunity 35, 780–791 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mellman, I. & Steinman, R. M. Dendritic cells: specialized and regulated antigen processing machines. Cell 106, 255–258 (2001).

Article  CAS  PubMed  Google Scholar 

Ohl, L. et al. CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity 21, 279–288 (2004).

Article  CAS  PubMed  Google Scholar 

Förster, R., Davalos-Misslitz, A. C. & Rot, A. CCR7 and its ligands: balancing immunity and tolerance. Nat. Rev. Immunol. 8, 362–371 (2008).

Article  PubMed  Google Scholar 

Ferris, S. T. et al. cDC1 prime and are licensed by CD4+ T cells to induce anti-tumour immunity. Nature 584, 624–629 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bosteels, C. et al. Inflammatory type 2 cDCs acquire features of cDC1s and macrophages to orchestrate immunity to respiratory virus infection. Immunity 52, 1039–1056.e9 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Desch, A. N. et al. Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction. Nat. Commun. 5, 4674 (2014).

Article  CAS  PubMed  Google Scholar 

Eickhoff, S. et al. Robust anti-viral immunity requires multiple distinct T cell-dendritic cell interactions. Cell 162, 1322–1337 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Borst, J., Ahrends, T., Bąbała, N., Melief, C. J. M. & Kastenmüller, W. CD4+ T cell help in cancer immunology and immunotherapy. Nat. Rev. Immunol. 18, 635–647 (2018).

Article  CAS  PubMed  Google Scholar 

Wilson, N. S. et al. Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling. Immunol. Cell Biol. 86, 200–205 (2008).

Article  CAS  PubMed  Google Scholar 

Ardouin, L. et al. Broad and largely concordant molecular changes characterize tolerogenic and immunogenic dendritic cell maturation in thymus and periphery. Immunity 45, 305–318 (2016). This study shows that homeostatically matured cDC1 are not just in a semi-mature state but share a common and distinct gene signature with immunogenically matured cDC1.

Article  CAS  PubMed  Google Scholar 

Bosteels, V. et al. LXR signaling controls homeostatic dendritic cell maturation. Sci. Immunol. 8, eadd3955 (2023). This study causally links the engulfment of apoptotic cells to the influx of cholesterol, the onset of homeostatic cDC1 maturation and the activation of LXR.

Article  CAS  PubMed  Google Scholar 

Kurts, C., Kosaka, H., Carbone, F. R., Miller, J. F. & Heath, W. R. Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8+ T cells. J. Exp. Med. 186, 239–245 (1997).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Belz, G. T. et al. The CD8α+ dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens. J. Exp. Med. 196, 1099–1104 (2002).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu, K. et al. Immune tolerance after delivery of dying cells to dendritic cells in situ. J. Exp. Med. 196, 1091–1097 (2002).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perry, J. S. A. et al. Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus. Immunity 41, 414–426 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perry, J. S. A. et al. Transfer of cell-surface antigens by scavenger receptor CD36 promotes thymic regulatory T cell receptor repertoire development and allo-tolerance. Immunity 48, 923–936.e4 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bourque, J. & Hawiger, D. Life and death of tolerogenic dendritic cells. Trends Immunol. 44, 110–118 (2023).

Article  CAS  PubMed