Mitochondrial dynamics as a potential therapeutic target in acute myeloid leukemia

Khwaja A, Bjorkholm M, Gale RE, Levine RL, Jordan CT, Ehninger G, et al. Acute myeloid leukaemia. Nat Rev Dis Primers. 2016;2:16010.

Article  PubMed  Google Scholar 

Döhner H, Wei AH, Appelbaum FR, Craddock C, DiNardo CD, Dombret H, et al. Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN. Blood. 2022;140:1345–77.

Article  PubMed  Google Scholar 

Hanahan D. Hallmarks of cancer: new dimensions. Cancer Discov. 2022;12:31–46.

Article  PubMed  Google Scholar 

Sainero-Alcolado L, Liaño-Pons J, Ruiz-Pérez MV, Arsenian-Henriksson M. Targeting mitochondrial metabolism for precision medicine in cancer. Cell Death Differ. 2022;29:1304–17.

Article  PubMed  PubMed Central  Google Scholar 

Skrtić M, Sriskanthadevan S, Jhas B, Gebbia M, Wang X, Wang Z, et al. Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell. 2011;20:674–88.

Article  PubMed  PubMed Central  Google Scholar 

Panina SB, Pei J, Kirienko NV. Mitochondrial metabolism as a target for acute myeloid leukemia treatment. Cancer Metab. 2021;9:17.

Article  PubMed  PubMed Central  Google Scholar 

Westermann B. Mitochondrial fusion and fission in cell life and death. Nat Rev Mol Cell Biol. 2010;11:872–84.

Article  PubMed  Google Scholar 

Giacomello M, Pyakurel A, Glytsou C, Scorrano L. The cell biology of mitochondrial membrane dynamics. Nat Rev Mol Cell Biol. 2020;21:204–24.

Article  PubMed  Google Scholar 

Losón OC, Song Z, Chen H, Chan DC. Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission. Mol Biol Cell. 2013;24:659–67.

Article  PubMed  PubMed Central  Google Scholar 

Hayashi Y, Harada H. Mitochondrial dynamics as a pathobiological mediator of clonal myeloid disorders. Cancer Sci. 2023;114:2722–8.

Article  PubMed  PubMed Central  Google Scholar 

Larrue C, Mouche S, Lin S, Simonetta F, Scheidegger NK, Poulain L, et al. Mitochondrial fusion is a therapeutic vulnerability of acute myeloid leukemia. Leukemia. 2023;37:765–75.

Article  PubMed  PubMed Central  Google Scholar 

Chen X, Glytsou C, Zhou H, Narang S, Reyna DE, Lopez A, et al. Targeting mitochondrial structure sensitizes acute myeloid leukemia to venetoclax treatment. Cancer Discov. 2019;9:890–909.

Article  PubMed  PubMed Central  Google Scholar 

Bordt EA, Clerc P, Roelofs BA, Saladino AJ, Tretter L, Adam-Vizi V, et al. The putative Drp1 inhibitor mdivi-1 Is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species. Dev Cell. 2017;40:583-594.e6.

Article  PubMed  PubMed Central  Google Scholar 

Cassidy-Stone A, Chipuk JE, Ingerman E, Song C, Yoo C, Kuwana T, et al. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell. 2008;14:193–204.

Article  PubMed  PubMed Central  Google Scholar 

Metzeler KH, Hummel M, Bloomfield CD, Spiekermann K, Braess J, Sauerland MC, et al. An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia. Blood. 2008;112:4193–201.

Article  PubMed  PubMed Central  Google Scholar 

Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, et al. NCBI GEO: archive for functional genomics data sets–update. Nucleic Acids Res. 2013;41:D991–5.

Article  PubMed  Google Scholar 

Pei S, Minhajuddin M, Adane B, Khan N, Stevens BM, Mack SC, et al. AMPK/FIS1-mediated mitophagy is required for self-renewal of human AML stem cells. Cell Stem Cell. 2018;23:86-100.e6.

Article  PubMed  PubMed Central  Google Scholar 

Saito Y, Kinoshita M, Yamada A, Kawano S, Liu HS, Kamimura S, et al. Mannose and phosphomannose isomerase regulate energy metabolism under glucose starvation in leukemia. Cancer Sci. 2021;112:4944–56.

Article  PubMed  PubMed Central  Google Scholar 

Warburg O. On respiratory impairment in cancer cells. Science. 1956;124:269–70.

Article  PubMed  Google Scholar 

Youle RJ, van der Bliek AM. Mitochondrial fission, fusion, and stress. Science. 2012;337:1062–5.

Article  PubMed  PubMed Central  Google Scholar 

Archer SL. Mitochondrial dynamics–mitochondrial fission and fusion in human diseases. N Engl J Med. 2013;369:2236–51.

Article  PubMed  Google Scholar 

Orrenius S, Gogvadze V, Zhivotovsky B. Mitochondrial oxidative stress: implications for cell death. Annu Rev Pharmacol Toxicol. 2007;47:143–83.

Article  PubMed  Google Scholar 

Chen H, Chan DC. Mitochondrial dynamics in regulating the unique phenotypes of cancer and stem cells. Cell Metab. 2017;26:39–48.

Article  PubMed  PubMed Central  Google Scholar 

Aoyagi Y, Hayashi Y, Harada Y, Choi K, Matsunuma N, Sadato D, et al. Mitochondrial fragmentation triggers ineffective hematopoiesis in myelodysplastic syndromes. Cancer Discov. 2022;12:250–69.

Article  PubMed  Google Scholar 

Rehman J, Zhang HJ, Toth PT, Zhang Y, Marsboom G, Hong Z, et al. Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer. FASEB J. 2012;26:2175–86.

Article  PubMed  PubMed Central  Google Scholar 

Zhao J, Zhang J, Yu M, Xie Y, Huang Y, Wolff DW, et al. Mitochondrial dynamics regulates migration and invasion of breast cancer cells. Oncogene. 2013;32:4814–24.

Article  PubMed  Google Scholar 

Nagdas S, Kashatus JA, Nascimento A, Hussain SS, Trainor RE, Pollock SR, et al. Drp1 promotes KRas-driven metabolic changes to drive pancreatic tumor growth. Cell Rep. 2019;28:1845-59.e5.

Article  PubMed  PubMed Central  Google Scholar 

Zamberlan M, Boeckx A, Muller F, Vinelli F, Ek O, Vianello C, et al. Inhibition of the mitochondrial protein Opa1 curtails breast cancer growth. J Exp Clin Cancer Res. 2022;41:95.

Article  PubMed  PubMed Central  Google Scholar 

Schimmer AD. Mitochondrial shapeshifting impacts AML stemness and differentiation. Cell Stem Cell. 2018;23:3–4.

Article  PubMed  Google Scholar 

Huang Q, Zhan L, Cao H, Li J, Lyu Y, Guo X, et al. Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFkB and TP53 pathways. Autophagy. 2016;12:999–1014.

Article  PubMed  PubMed Central  Google Scholar 

Guido C, Whitaker-Menezes D, Lin Z, Pestell RG, Howell A, Zimmers TA, et al. Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth. Oncotarget. 2012;3:798–810.

Article  PubMed  PubMed Central  Google Scholar 

Hu M, Zhao Y, Cao Y, Tang Q, Feng Z, Ni J, et al. DRP1 promotes lactate utilization in KRAS-mutant non-small-cell lung cancer cells. Cancer Sci. 2020;111:3588–99.

Article  PubMed  PubMed Central  Google Scholar 

Jang JE, Hwang DY, Eom JI, Cheong JW, Jeung HK, Cho H, et al. DRP1 inhibition enhances venetoclax-induced mitochondrial apoptosis in TP53-mutated acute myeloid leukemia cells through BAX/BAK activation. Cancers. 2023;15:745.

留言 (0)

沒有登入
gif