METTL3 silencing inhibits ferroptosis to suppress ovarian fibrosis in PCOS by upregulating m6A modification of GPX4

Bolívar S et al (2023) The role of METTL3 in the progression of cardiac fibrosis. Curr Top Med Chem 23(26):2427–2435

Article  PubMed  Google Scholar 

Bulut G et al (2015) Effects of jnk inhibitor on inflammation and fibrosis in the ovary tissue of a rat model of polycystic ovary syndrome. Int J Clin Exp Pathol 8(8):8774–8785

PubMed  PubMed Central  Google Scholar 

Cai W et al (2023) Alox15/15-HpETE aggravates myocardial ischemia-reperfusion injury by promoting cardiomyocyte ferroptosis. Circulation 147(19):1444–1460

Article  CAS  PubMed  Google Scholar 

Chen X et al (2021a) Broadening horizons: the role of ferroptosis in cancer. Nat Rev Clin Oncol 18(5):280–296

Article  CAS  PubMed  Google Scholar 

Chen X et al (2021b) Ferroptosis: machinery and regulation. Autophagy 17(9):2054–2081

Article  CAS  PubMed  Google Scholar 

Chen L et al (2022) METTL3-mediated m6A modification stabilizes TERRA and maintains telomere stability. Nucleic Acids Res 50(20):11619–11634

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng H et al (2021) Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis. Biochim Biophys Acta Mol Basis Dis 1867:166204

Article  CAS  PubMed  Google Scholar 

DiRenzo DM et al (2016) A crosstalk between TGF-β/Smad3 and Wnt/β-catenin pathways promotes vascular smooth muscle cell proliferation. Cell Signal 28(5):498–505

Article  CAS  PubMed  PubMed Central  Google Scholar 

Escobar-Morreale HF (2012) Iron metabolism and the polycystic ovary syndrome. Trends Endocrinol Metab 23(10):509–515

Article  CAS  PubMed  Google Scholar 

Franks S (2006) Controversy in clinical endocrinology: diagnosis of polycystic ovarian syndrome: in defense of the Rotterdam criteria. J Clin Endocrinol Metab 91(3):786–789

Article  CAS  PubMed  Google Scholar 

Gleicher N et al (2022) Reconsidering the polycystic ovary syndrome (PCOS). Biomedicines 10(7):1505

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khan MJ, Ullah A, Basit S (2019) Genetic basis of polycystic ovary syndrome (PCOS): current perspectives. Appl Clin Genet 12:249–260

Article  PubMed  PubMed Central  Google Scholar 

Lambertini L et al (2017) Intrauterine reprogramming of the polycystic ovary syndrome: evidence from a pilot study of cord blood global methylation analysis. Front Endocrinol 8:352

Article  Google Scholar 

Leask A, Abraham DJ (2004) TGF-beta signaling and the fibrotic response. Faseb j 18(7):816–827

Article  CAS  PubMed  Google Scholar 

Li T et al (2021) Silencing of METTL3 attenuates cardiac fibrosis induced by myocardial infarction via inhibiting the activation of cardiac fibroblasts. Faseb J 35(2):e21162

Article  CAS  PubMed  Google Scholar 

Li Y et al (2022) The m(6)A methyltransferase Mettl3 deficiency attenuates hepatic stellate cell activation and liver fibrosis. Mol Ther 30(12):3714–3728

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin Q et al (2023) Mitophagy alleviates cisplatin-induced renal tubular epithelial cell ferroptosis through ROS/HO-1/GPX4 axis. Int J Biol Sci 19(4):1192–1210

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu ZX et al (2018) Link between m6A modification and cancers. Front Bioeng Biotechnol 6:89

Article  PubMed  PubMed Central  Google Scholar 

Liu H et al (2022) Cryptotanshinone protects against PCOS-induced damage of ovarian tissue via regulating oxidative stress, mitochondrial membrane potential, inflammation, and apoptosis via regulating ferroptosis. Oxid Med Cell Longev 2022:8011850

PubMed  PubMed Central  Google Scholar 

Ni WJ et al (2023) Genetic and pharmacological inhibition of METTL3 alleviates renal fibrosis by reducing EVL m6A modification through an IGF2BP2-dependent mechanism. Clin Transl Med 13(8):e1359

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oerum S et al (2021) A comprehensive review of m6A/m6Am RNA methyltransferase structures. Nucleic Acids Res 49(13):7239–7255

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng Q et al (2023) Metformin improves polycystic ovary syndrome in mice by inhibiting ovarian ferroptosis. Front Endocrinol 14:1070264

Article  Google Scholar 

Shen M et al (2021) N(6)-methyladenosine modification regulates ferroptosis through autophagy signaling pathway in hepatic stellate cells. Redox Biol 47:102151

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shu B et al (2021) The METTL3/MALAT1/PTBP1/USP8/TAK1 axis promotes pyroptosis and M1 polarization of macrophages and contributes to liver fibrosis. Cell Death Discov 7(1):368

Article  CAS  PubMed  PubMed Central  Google Scholar 

Siddiqui S et al (2022) A brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS). J Assist Reprod Genet 39(11):2439–2473

Article  PubMed  PubMed Central  Google Scholar 

Song T et al (2019) Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation. Nucleic Acids Res 47(12):6130–6144

Article  CAS  PubMed  PubMed Central  Google Scholar 

Song Z et al (2021) Exosomal miR-4443 promotes cisplatin resistance in non-small cell lung carcinoma by regulating FSP1 m6A modification-mediated ferroptosis. Life Sci 276:119399

Article  CAS  PubMed  Google Scholar 

Tu B et al (2023) METTL3 boosts mitochondrial fission and induces cardiac fibrosis by enhancing LncRNA GAS5 methylation. Pharmacol Res 194:106840

Article  CAS  PubMed  Google Scholar 

Wang D et al (2018) DHEA-induced ovarian hyperfibrosis is mediated by TGF-β signaling pathway. J Ovarian Res 11(1):6

Article  PubMed  PubMed Central  Google Scholar 

Wang D et al (2020a) Suppression of p66Shc prevents hyperandrogenism-induced ovarian oxidative stress and fibrosis. J Transl Med 18(1):84

Article  PubMed  PubMed Central  Google Scholar 

Wang J et al (2020b) Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload. Cell Death Dis 11(7):574

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y et al (2023) METTL3-mediated m6A modification of HMGA2 mRNA promotes subretinal fibrosis and epithelial-mesenchymal transition. J Mol Cell Biol. https://doi.org/10.1093/jmcb/mjad005

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