Compston JE, McClung MR, Leslie WD (2019) Osteoporosis. The Lancet 393:364–376

Article  CAS  Google Scholar 

Napoli N, Chandran M, Pierroz DD, Abrahamsen B, Schwartz AV, Ferrari SL (2016) Mechanisms of diabetes mellitus-induced bone fragility. Nat Rev Endocrinol 13:208–219

Article  PubMed  Google Scholar 

Leanza G, Maddaloni E, Pitocco D et al (2019) Risk factors for fragility fractures in type 1 diabetes. Bone 125:194–199

Article  CAS  PubMed  Google Scholar 

Weber DR, Haynes K, Leonard MB, Willi SM, Denburg MR (2015) Type 1 diabetes is associated with an increased risk of fracture across the life span: a population-based cohort study using The Health Improvement Network (THIN). Diabetes Care 38:1913–1920

Article  PubMed  PubMed Central  Google Scholar 

Janghorbani M, Feskanich D, Willett WC, Hu F (2006) Prospective study of diabetes and risk of hip fracture. Diabetes Care 29:1573–1578

Article  PubMed  Google Scholar 

Khosla S, Samakkarnthai P, Monroe DG, Farr JN (2021) Update on the pathogenesis and treatment of skeletal fragility in type 2 diabetes mellitus. Nat Rev Endocrinol 17:685–697

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee NK, Sowa H, Hinoi E et al (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130:456–469

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferron M, Wei J, Yoshizawa T, Del Fattore A, DePinho RA, Teti A, Ducy P, Karsenty G (2010) Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell 142:296–308

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thomas DM, Hards DK, Rogers SD, Ng KW, Best JD (1996) Insulin receptor expression in bone. J Bone Miner Res 11:1312–1320

Article  CAS  PubMed  Google Scholar 

Reaven GM (1995) Pathophysiology of insulin resistance in human disease. Physiol Rev 75:473–486

Article  CAS  PubMed  Google Scholar 

Petersen MC, Shulman GI (2018) Mechanisms of insulin action and insulin resistance. Physiol Rev 98:2133–2223

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nolan CJ, Prentki M (2019) Insulin resistance and insulin hypersecretion in the metabolic syndrome and type 2 diabetes: time for a conceptual framework shift. Diab Vasc Dis Res 16:118–127

Article  CAS  PubMed  Google Scholar 

James DE, Stockli J, Birnbaum MJ (2021) The aetiology and molecular landscape of insulin resistance. Nat Rev Mol Cell Biol 22:751–771

Article  CAS  PubMed  Google Scholar 

Ruze R, Liu T, Zou X, Song J, Chen Y, Xu R, Yin X, Xu Q (2023) Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments. Front Endocrinol (Lausanne) 14:1161521

Article  PubMed  Google Scholar 

Li M, Chi X, Wang Y, Setrerrahmane S, Xie W, Xu H (2022) Trends in insulin resistance: insights into mechanisms and therapeutic strategy. Signal Transduct Target Ther 7:216–216

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xourafa G, Korbmacher M, Roden M (2023) Inter-organ crosstalk during development and progression of type 2 diabetes mellitus. Nat Rev Endocrinol 20:27–49

Article  PubMed  Google Scholar 

Ferron M, Lacombe J (2014) Regulation of energy metabolism by the skeleton: osteocalcin and beyond. Arch Biochem Biophys 561:137–146

Article  CAS  PubMed  Google Scholar 

Ferron M, McKee MD, Levine RL, Ducy P, Karsenty G (2012) Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice. Bone 50:568–575

Article  CAS  PubMed  Google Scholar 

Han Y, You X, Xing W, Zhang Z, Zou W (2018) Paracrine and endocrine actions of bone-the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts. Bone Res 6:16–16

Article  PubMed  PubMed Central  Google Scholar 

Anastasilakis AD, Tsourdi E, Tabacco G, Naciu AM, Napoli N, Vescini F, Palermo A (2021) The impact of antiosteoporotic drugs on glucose metabolism and fracture risk in diabetes: good or bad news? J Clin Med 10:996

Article  CAS  PubMed  PubMed Central  Google Scholar 

Greenhill C (2018) Role of bone in glucose metabolism. Nat Rev Endocrinol 14:191–191

Article  PubMed  Google Scholar 

Dirckx N, Moorer MC, Clemens TL, Riddle RC (2019) The role of osteoblasts in energy homeostasis. Nat Rev Endocrinol 15:651–665

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guntur AR, Le PT, Farber CR, Rosen CJ (2014) Bioenergetics during calvarial osteoblast differentiation reflect strain differences in bone mass. Endocrinology 155:1589–1595

Article  PubMed  PubMed Central  Google Scholar 

Lee W-C, Ji X, Nissim I, Long F (2020) Malic enzyme couples mitochondria with aerobic glycolysis in osteoblasts. Cell Rep 32:108108–108108

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fulzele K, Riddle RC, DiGirolamo DJ et al (2010) Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell 142:309–319

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oh JH, Lee NK (2017) Up-regulation of RANK expression via ERK1/2 by insulin contributes to the enhancement of osteoclast differentiation. Mol Cells 40:371–377

Article  CAS  PubMed  PubMed Central  Google Scholar 

Conte C, Epstein S, Napoli N (2018) Insulin resistance and bone: a biological partnership. Acta Diabetol 55:305–314

Article  CAS  PubMed  Google Scholar 

Zhou R, Guo Q, Xiao Y, Guo Q, Huang Y, Li C, Luo X (2021) Endocrine role of bone in the regulation of energy metabolism. Bone Res 9:25–25

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barrett-Connor E, Kritz-Silverstein D (1996) Does hyperinsulinemia preserve bone? Diabetes Care 19:1388–1392

Article  CAS  PubMed  Google Scholar 

Stolk RP, Van Daele PLA, Pols HAP, Burger H, Hofman A, Birkenhäger JC, Lamberts SWJ, Grobbee DE (1996) Hyperinsulinemia and bone mineral density in an elderly population: the Rotterdam study. Bone 18:545–549

Article  CAS  PubMed  Google Scholar 

Arikan S, Tuzcu A, Bahceci M, Ozmen S, Gokalp D (2012) Insulin resistance in type 2 diabetes mellitus may be related to bone mineral density. J Clin Densitom 15:186–190