Insights on prevalence and incidence of anemia and rapid up-titration of oral heart failure treatment from the STRONG-HF study

Mebazaa A, Davison B, Chioncel O, Cohen-Solal A, Diaz R, Filippatos G, Metra M, Ponikowski P, Sliwa K, Voors AA, Edwards C, Novosadova M, Takagi K, Damasceno A, Saidu H, Gayat E, Pang PS, Celutkiene J, Cotter G (2022) Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial. Lancet. https://doi.org/10.1016/S0140-6736(22)02076-1

Article  PubMed  Google Scholar 

McDonagh TA, Metra M, Adamo M, Baumbach A, Böhm M, Burri H, Čelutkiene J, Chioncel O, Cleland JGF, Coats AJS, Crespo-Leiro MG, Farmakis D, Gardner RS, Gilard M, Heymans S, Hoes AW, Jaarsma T, Jankowska EA, Lainscak M, Lam CSP, Lyon AR, McMurray JJV, Mebazaa A, Mindham R, Muneretto C, Piepoli MF, Price S, Rosano GMC, Ruschitzka F, Skibelund AK, de Boer RA, Schulze PC, Abdelhamid M, Aboyans V, Adamopoulos S, Anker SD, Arbelo E, Asteggiano R, Bauersachs J, Bayes-Genis A, Borger MA, Budts W, Cikes M, Damman K, Delgado V, Dendale P, Dilaveris P, Drexel H, Ezekowitz J, Falk V, Fauchier L, Filippatos G, Fraser A, Frey N, Gale CP, Gustafsson F, Harris J, Iung B, Janssens S, Jessup M, Konradi A, Kotecha D, Lambrinou E, Lancellotti P, Landmesser U, Leclercq C, Lewis BS, Leyva F, Linhart A, Løchen ML, Lund LH, Mancini D, Masip J, Milicic D, Mueller C, Nef H, Nielsen JC, Neubeck L, Noutsias M, Petersen SE, Petronio AS, Ponikowski P, Prescott E, Rakisheva A, Richter D, Schlyakhto E, Seferovic P, Senni M, Sitges M, Sousa-Uva M, Tocchetti CG, Touyz R, Tschoepe C, Waltenberger J, Krim M, Hayrapetyan H, Moertl D, Mustafayev I, Kurlianskaya A, Depauw M, Kušljugić Z, Gatzov P, Agathangelou P, Melenovský V, Løgstrup BB, Mostafa AM, Uuetoa T, Lassus J, Logeart D, Kipiani Z, Chrysohoou C, Sepp R, Ingimarsdóttir IJ, O’Neill J, Gotsman I, Iacoviello M, Bajraktari G, Lunegova O, Kamzola G, Massih TA, Benlamin H, Žaliaduonyte D, Noppe S, Moore A, Vataman E, Boskovic A, Bennis A, Manintveld OC, Kostovska ES, Gulati G, Straburzyńska-Migaj E, Silva-Cardoso J, Rimbaş RC, Lopatin Y, Foscoli M, Stojkovic S, Goncalvesova E, Fras Z, Segovia J, Lindmark K, Maeder MT, Bsata W, Abid L, Altay H, Voronkov L, Davies C, Abdullaev T, Baigent CN, Antoniou S, Collet JP, Halvorsen S, Koskinas KC (2021) ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: developed by the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 42:3599–3726. https://doi.org/10.1093/EURHEARTJ/EHAB368

Article  CAS  PubMed  Google Scholar 

McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, Burri H, Butler J, Čelutkienė J, Chioncel O, Cleland JGF, Crespo-Leiro MG, Farmakis D, Gilard M, Heymans S, Hoes AW, Jaarsma T, Jankowska EA, Lainscak M, Lam CSP, Lyon AR, McMurray JJV, Mebazaa A, Mindham R, Muneretto C, Piepoli MF, Price S, Rosano GMC, Ruschitzka F, Skibelund AK, Group ESD, de Boer RA, Schulze PC, Arbelo E, Bartunek J, Bauersachs J, Borger MA, Buccheri S, Cerbai E, Donal E, Edelmann F, Färber G, Heidecker B, Ibanez B, James S, Køber L, Koskinas KC, Masip J, McEvoy JW, Mentz R, Mihaylova B, Møller JE, Mullens W, Neubeck L, Nielsen JC, Pasquet AA, Ponikowski P, Prescott E, Rakisheva A, Rocca B, Rossello X, Sade LE, Schaubroeck H, Tessitore E, Tokmakova M, van der Meer P, Van Gelder IC, Van Heetvelde M, Vrints C, Wilhelm M, Witkowski A, Zeppenfeld K, Shuka N, Chettibi M, Hayrapetyan H, Pavo N, Islamli A, Pouleur A-C, Kusljugic Z, Tokmakova M, Milicic D, Christodoulides T, Malek F, Køber L, Koriem MAG, Põder P, Lassus J, Roubille F, Agladze V, Frantz S, Stavrati A, Kosztin A, Ingimarsdóttir IJ, Campbell P, Hasin T, Oliva F, Aidargaliyeva N, Bajraktari G, Mirrakhimov E, Kamzola G, El Neihoum AM, Zaliaduonyte D, Moore A, Vataman E, Boskovic A, Alami M, Manintveld O, Kostovska ES, Broch K, Nessler J, Franco F, Popescu BA, Foscoli M, Milosavljevic AS, Goncalvesova E, Fras Z, Gonzalez-Costello J, Lindmark K, Paul M, Oudeh A, Zakhama L, Celik A, Voronkov L, Clark A, Abdullaev T, Prescott E, James S, Arbelo E, Baigent C, Borger MA, Buccheri S, Ibanez B, Køber L, Koskinas KC, McEvoy JW, Mihaylova B, Mindham R, Neubeck L, Nielsen JC, Pasquet AA, Rakisheva A, Rocca B, Rossello X, Vaartjes I, Vrints C, Witkowski A, Zeppenfeld K (2023) Eur Heart J 44:3627–3639. https://doi.org/10.1093/EURHEARTJ/EHAD195

Article  CAS  PubMed  Google Scholar 

Chioncel O, Davison B, Adamo M, Antohi LE, Arrigo M, Barros M, Biegus J, Čerlinskaitė-Bajorė K, Celutkiene J, Cohen-Solal A, Damasceno A, Diaz R, Edwards C, Filippatos G, Kimmoun A, Lam CSP, Metra M, Novosadova M, Pagnesi M, Pang PS, Ponikowski P, Radu RI, Saidu H, Sliwa K, Voors AA, Takagi K, Ter Maaten JM, Tomasoni D, Cotter G, Mebazaa A (2023) Non-cardiac comorbidities and intensive up-titration of oral treatment in patients recently hospitalized for heart failure: Insights from the STRONG-HF trial. Eur J Heart Fail 25:1994–2006. https://doi.org/10.1002/EJHF.3039

Article  CAS  PubMed  Google Scholar 

Groenveld HF, Januzzi JL, Damman K, van Wijngaarden J, Hillege HL, van Veldhuisen DJ, van der Meer P (2008) Anemia and mortality in heart failure patients: a systematic review and meta-analysis. J Am Coll Cardiol 52:818–827. https://doi.org/10.1016/J.JACC.2008.04.061

Article  PubMed  Google Scholar 

Ishani A, Weinhandl E, Zhao Z, Gilbertson DT, Collins AJ, Yusuf S, Herzog CA (2005) Angiotensin-converting enzyme inhibitor as a risk factor for the development of anemia, and the impact of incident anemia on mortality in patients with left ventricular dysfunction. J Am Coll Cardiol 45:391–399. https://doi.org/10.1016/J.JACC.2004.10.038

Article  CAS  PubMed  Google Scholar 

Azizi M, Junot C, Ezan E, Ménard J (2001) Angiotensin I-converting enzyme and metabolism of the haematological peptide N-acetyl-seryl-aspartyl-lysyl-proline. Clin Exp Pharmacol Physiol 28:1066–1069. https://doi.org/10.1046/J.1440-1681.2001.03560.X

Article  CAS  PubMed  Google Scholar 

Komajda M, Anker SD, Charlesworth A, Okonko D, Metra M, Di Lenarda A, Remme W, Moullet C, Swedberg K, Cleland JGF, Poole-Wilson PA (2006) The impact of new onset anaemia on morbidity and mortality in chronic heart failure: results from COMET. Eur Heart J 27:1440–1446. https://doi.org/10.1093/EURHEARTJ/EHL012

Article  PubMed  Google Scholar 

McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR (2014) PARADIGM-HF investigators and committees, angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med 371:993–1004. https://doi.org/10.1056/NEJMoa1409077

Article  CAS  PubMed  Google Scholar 

McMurray JJV, Solomon SD, Inzucchi SE, Køber L, Kosiborod MN, Martinez FA, Ponikowski P, Sabatine MS, Anand IS, Bělohlávek J, Böhm M, Chiang C-E, Chopra VK, de Boer RA, Desai AS, Diez M, Drozdz J, Dukát A, Ge J, Howlett JG, Katova T, Kitakaze M, Ljungman CEA, Merkely B, Nicolau JC, O’Meara E, Petrie MC, Vinh PN, Schou M, Tereshchenko S, Verma S, Held C, DeMets DL, Docherty KF, Jhund PS, Bengtsson O, Sjöstrand M, Langkilde A-M (2019) Dapagliflozin in patients with heart failure and reduced ejection fraction. Clinical Trial 381:1995–2008. https://doi.org/10.1056/NEJMOA1911303

Article  CAS  Google Scholar 

Streng KW, Nauta JF, Hillege HL, Anker SD, Cleland JG, Dickstein K, Filippatos G, Lang CC, Metra M, Ng LL, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zwinderman AH, Zannad F, Damman K, van der Meer P, Voors AA (2018) Non-cardiac comorbidities in heart failure with reduced, mid-range and preserved ejection fraction. Int J Cardiol 271:132–139. https://doi.org/10.1016/J.IJCARD.2018.04.001

Article  PubMed  Google Scholar 

Chioncel O, Benson L, Crespo-Leiro MG, Anker SD, Coats AJS, Filippatos G, McDonagh T, Margineanu C, Mebazaa A, Metra M, Piepoli MF, Adamo M, Rosano GMC, Ruschitzka F, Savarese G, Seferovic P, Volterrani M, Ferrari R, Maggioni AP, Lund LH (2023) Comprehensive characterization of non-cardiac comorbidities in acute heart failure: an analysis of ESC-HFA EURObservational Research Programme Heart Failure Long-Term Registry. Eur J Prev Cardiol 30:1346–1358. https://doi.org/10.1093/EURJPC/ZWAD151

Article  PubMed  Google Scholar 

Fox MT, Jorde UP (2005) Anemia, chronic heart failure, and the impact of male vs female gender. Congest Heart Fail 11:129–132. https://doi.org/10.1111/J.1527-5299.2005.03953.X

Article  PubMed  Google Scholar 

Go AS, Yang J, Ackerson LM, Lepper K, Robbins S, Massie BM, Shlipak MG (2006) Hemoglobin level, chronic kidney disease, and the risks of death and hospitalization in adults with chronic heart failure. Circulation 113:2713–2723. https://doi.org/10.1161/CIRCULATIONAHA.105.577577

Article  CAS  PubMed  Google Scholar 

Mehdi U, Toto RD (2009) Anemia, diabetes, and chronic kidney disease. Diabetes Care 32:1320–1326. https://doi.org/10.2337/DC08-0779

Article  PubMed  PubMed Central  Google Scholar 

Shah R, Agarwal AK (2013) Anemia associated with chronic heart failure: current concepts. Clin Interv Aging 8:111. https://doi.org/10.2147/CIA.S27105

Article  CAS  PubMed  PubMed Central  Google Scholar 

Van Der Meer P, Lipsic E, Westenbrink BD, Van De Wal RMA, Schoemaker RG, Vellenga E, Van Veldhuisen DJ, Voors AA, Van Gilst WH (2005) Levels of hematopoiesis inhibitor N-acetyl-seryl-aspartyl-lysyl-proline partially explain the occurrence of anemia in heart failure. Circulation 112:1743–1747. https://doi.org/10.1161/CIRCULATIONAHA.105.549121

Article  CAS  PubMed  Google Scholar 

Anand IS, Kuskowski MA, Rector TS, Florea VG, Glazer RD, Hester A, Chiang YT, Aknay N, Maggioni AP, Opasich C, Latini R, Cohn JN (2005) Anemia and change in hemoglobin over time related to mortality and morbidity in patients with chronic heart failure. Circulation 112:1121–1127. https://doi.org/10.1161/CIRCULATIONAHA.104.512988

Article  CAS  PubMed  Google Scholar 

Guralnik JM, Ershler WB, Schrier SL, Picozzi VJ (2005) Anemia in the elderly: a public health crisis in hematology. Hematology 2005:528–532. https://doi.org/10.1182/ASHEDUCATION-2005.1.528

Article  Google Scholar 

Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC (2004) Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood 104:2263–2268. https://doi.org/10.1182/BLOOD-2004-05-1812

Article  CAS  PubMed  Google Scholar 

Mansoor F, Bai P, Kaur N, Sultan S, Sharma S, Dilip A, Kammawal Y, Shahid S, Rizwan A (2021) Evaluation of serum electrolyte levels in patients with anemia. Cureus. https://doi.org/10.7759/CUREUS.18417

Article  PubMed  PubMed Central  Google Scholar 

Rafiq M, Arooj A, Tahir Q-A, Fayyaz N, Samad A, Bashir S (2021) Evaluation of serum electrolyte levels in iron deficiency anemia patients. Prof Med J 28:691–696. https://doi.org/10.29309/TPMJ/2021.28.05.5702

Article 

留言 (0)

沒有登入
gif