Mehta PK, Quesada O, Al-Badri A et al (2022) Ischemia and no obstructive coronary arteries in patients with stable ischemic heart disease. Int J Cardiol 348:1–8

PubMed  Google Scholar 

Feuer DS, Handberg EM, Mehrad B et al (2022) Microvascular dysfunction as a systemic disease: a review of the evidence. Am J Med 135:1059–1068

PubMed  PubMed Central  Google Scholar 

Del Buono MG, Montone RA, Camilli M et al (2021) Coronary microvascular dysfunction across the spectrum of cardiovascular diseases: JACC state-of-the-art review. J Am Coll Cardiol 78:1352–1371

PubMed  PubMed Central  Google Scholar 

Chacko L, J PH, Rajkumar C et al (2020) Effects of percutaneous coronary intervention on death and myocardial infarction stratified by stable and unstable coronary artery disease: a meta-analysis of randomized controlled trials. Circ Cardiovasc Qual Outcomes 13:e006363

PubMed  PubMed Central  Google Scholar 

Al-Lamee R, Thompson D, Dehbi HM et al (2018) Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial. Lancet 391:31–40

PubMed  Google Scholar 

Maron DJ, Hochman JS, Reynolds HR et al (2020) Initial invasive or conservative strategy for stable coronary disease. N Engl J Med 382:1395–1407

PubMed  PubMed Central  Google Scholar 

Kei CY, Singh K, Dautov RF, Nguyen TH, Chirkov YY, Horowitz JD (2023) Coronary “microvascular dysfunction”: evolving understanding of pathophysiology, clinical implications, and potential therapeutics. Int J Mol Sci 24(14):11287

CAS  PubMed  PubMed Central  Google Scholar 

Sinha A, Rahman H, Perera D (2023) Coronary microvascular dysfunction and heart failure with preserved ejection fraction: what are the mechanistic links? Curr Opin Cardiol. https://doi.org/10.1097/HCO.0000000000001082

Article  PubMed  PubMed Central  Google Scholar 

Rim TH, Teo AWJ, Yang HHS, Cheung CY, Wong TY (2020) Retinal vascular signs and cerebrovascular diseases. J Neuroophthalmol 40:44–59

PubMed  Google Scholar 

Yanai H, Adachi H, Hakoshima M, Katsuyama H (2023) Significance of endothelial dysfunction amelioration for sodium-glucose cotransporter 2 inhibitor-induced improvements in heart failure and chronic kidney disease in diabetic patients. Metabolites 13(6):736

CAS  PubMed  PubMed Central  Google Scholar 

Nowroozpoor A, Gutterman D, Safdar B (2021) Is microvascular dysfunction a systemic disorder with common biomarkers found in the heart, brain, and kidneys? - a scoping review. Microvasc Res 134:104123

CAS  PubMed  Google Scholar 

D’Amario D, Migliaro S, Borovac JA et al (2019) Microvascular dysfunction in heart failure with preserved ejection fraction. Front Physiol 10:1347

PubMed  PubMed Central  Google Scholar 

Shah SJ, Lam CSP, Svedlund S et al (2018) Prevalence and correlates of coronary microvascular dysfunction in heart failure with preserved ejection fraction: PROMIS-HFpEF. Eur Heart J 39:3439–3450

CAS  PubMed  PubMed Central  Google Scholar 

El Sabbagh A, Prasad M, Zack CJ et al (2018) High-sensitivity troponin in patients with coronary artery endothelial dysfunction. J Invasive Cardiol 30:406–410

PubMed  Google Scholar 

Luft T, Dreger P, Radujkovic A (2021) Endothelial cell dysfunction: a key determinant for the outcome of allogeneic stem cell transplantation. Bone Marrow Transplant 56:2326–2335

PubMed  PubMed Central  Google Scholar 

Carreras E, Diaz-Ricart M (2011) The role of the endothelium in the short-term complications of hematopoietic SCT. Bone Marrow Transplant 46:1495–1502

CAS  PubMed  Google Scholar 

Mir E, Palomo M, Rovira M et al (2017) Endothelial damage is aggravated in acute GvHD and could predict its development. Bone Marrow Transplant 52:1317–1325

CAS  PubMed  Google Scholar 

Song GY, Jung SH, Kim K et al (2020) Endothelial activation and stress index (EASIX) is a reliable predictor for overall survival in patients with multiple myeloma. BMC Cancer 20:803

CAS  PubMed  PubMed Central  Google Scholar 

Go SI, Park S, Kang MH et al (2022) Endothelial activation and stress index (EASIX) as a predictive biomarker in small cell lung cancer. Cancer Biomark 35:217–225

CAS  PubMed  Google Scholar 

Gu JS, Ryu JW, Yu SH et al (2022) Prognostic value of the endothelial activation and stress index in patients with upper tract urothelial cancer undergoing radical nephroureterectomy. Investig Clin Urol 63:623–630

PubMed  PubMed Central  Google Scholar 

Merz A, Germing U, Kobbe G et al (2019) EASIX for prediction of survival in lower-risk myelodysplastic syndromes. Blood Cancer J 9:85

PubMed  PubMed Central  Google Scholar 

Fuster JJ, MacLauchlan S, Zuriaga MA et al (2017) Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice. Science 355:842–847

CAS  PubMed  PubMed Central  Google Scholar 

Dorsheimer L, Assmus B, Rasper T et al (2019) Association of mutations contributing to clonal hematopoiesis with prognosis in chronic ischemic heart failure. JAMA Cardiol 4:25–33

PubMed  Google Scholar 

Akhiyat N, Lasho T, Ganji M et al (2023) Clonal hematopoiesis of indeterminate potential is associated with coronary microvascular dysfunction in early nonobstructive coronary artery disease. Arterioscler Thromb Vasc Biol 43:774–783

CAS  PubMed  PubMed Central  Google Scholar 

Bitzan M, Hammad RM, Bonnefoy A, Al Dhaheri WS, Vezina C, Rivard GE (2018) Acquired thrombotic thrombocytopenic purpura with isolated CFHR3/1 deletion-rapid remission following complement blockade. Pediatr Nephrol 33:1437–1442

PubMed  PubMed Central  Google Scholar 

Ruutu T, Barosi G, Benjamin RJ et al (2007) Diagnostic criteria for hematopoietic stem cell transplant-associated microangiopathy: results of a consensus process by an international working group. Haematologica 92:95–100

PubMed  Google Scholar 

Luft T, Benner A, Terzer T et al (2020) EASIX and mortality after allogeneic stem cell transplantation. Bone Marrow Transplant 55:553–561

CAS  PubMed  Google Scholar 

Luft T, Benner A, Jodele S et al (2017) EASIX in patients with acute graft-versus-host disease: a retrospective cohort analysis. Lancet Haematol 4:e414–e423

PubMed  Google Scholar 

Korell F, Schreck N, Muller-Tidow C, Dreger P, Luft T, Taskforce allogeneic Stem Cell Transplantation UHH (2022) Pre-transplant EASIX and sepsis after allogeneic stem cell transplantation. Intensive Care Med 48:753–755

PubMed  PubMed Central  Google Scholar 

Korell F, DeFilipp Z, Schreck N, Luft T, Taskforces Allogeneic Stem Cell T (2023) Validation of pre-conditioning EASIX for prediction of sepsis after allogeneic stem cell transplantation. Intensive Care Med 49(11):1408–1410

PubMed  PubMed Central  Google Scholar 

Xu HB, Ye Y, Xue F, Wu J, Suo Z, Zhang H (2023) Association between endothelial activation and stress index and 28 day mortality in septic ICU patients: a retrospective cohort study. Int J Med Sci 20:1165–1173

CAS  PubMed  PubMed Central  Google Scholar 

Schult D, Rasch S, Schmid RM, Lahmer T, Mayr U (2023) EASIX is an accurate and easily available prognostic score in critically Ill patients with advanced liver disease. J Clin Med 12(7):2553

CAS  PubMed  PubMed Central  Google Scholar 

Luft T, Wendtner CM, Kosely F et al (2021) EASIX for prediction of outcome in hospitalized SARS-CoV-2 infected patients. Front Immunol 12:634416

CAS  PubMed  PubMed Central  Google Scholar 

McDonagh TA, Metra M, Adamo M et al (2021) 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J 42:3599–3726

CAS  PubMed  Google Scholar 

Luft PDT, Heidelberg UH (2022) The Endothelial Cell Dysfunction and Outcome Project for Hematological Neoplasms. https://classic.clinicaltrials.gov/show/NCT05502887

Royston P, Altman DG (2013) External validation of a Cox prognostic model: principles and methods. BMC Med Res Methodol 13:33

PubMed  PubMed Central  Google Scholar 

Nawas MT, Sanchez-Escamilla M, Devlin SM et al (2022) Dynamic EASIX scores closely predict nonrelapse mortality after allogeneic hematopoietic cell transplantation. Blood Adv 6:5898–5907

PubMed  PubMed Central  Google Scholar 

Park S, Go SI, Lee GW (2022) The endothelial activation and stress ind