Misfolding and aggregation in neurodegenerative diseases: protein quality control machinery as potential therapeutic clearance pathways

Sweeney P, Park H, Baumann M, Dunlop J, Frydman J, Kopito R, et al. Protein misfolding in neurodegenerative diseases: implications and strategies. Transl Neurodegener. 2017;6:6.

Article  PubMed  PubMed Central  Google Scholar 

Katsuno M, Sahashi K, Iguchi Y, Hashizume A. Preclinical progression of neurodegenerative diseases. Nagoya University Graduate School of Medicine, School of Medicine; 2018. https://doi.org/10.18999/nagjms.80.3.289. Cited 2023 Aug 1.

Metcalfe SM, Bickerton S, Fahmy T. Neurodegenerative disease: a perspective on cell-based therapy in the new era of cell-free nano-therapy. CPD. 2017;23:776–83.

Article  CAS  Google Scholar 

Barthélemy NR, Salvadó G, Schindler SE, He Y, Janelidze S, Collij LE, et al. Highly accurate blood test for Alzheimer’s disease is similar or superior to clinical cerebrospinal fluid tests. Nat Med. 2024;30:1085–95.

Article  PubMed  PubMed Central  Google Scholar 

Gulisano W, Maugeri D, Baltrons MA, Fà M, Amato A, Palmeri A, et al. Role of amyloid-β and tau proteins in Alzheimer’s disease: confuting the amyloid cascade. Perry G, Avila J, Moreira PI, Sorensen AA, Tabaton M, editors. JAD. 2018;64:S611–31.

Article  CAS  PubMed  Google Scholar 

Abubakar MB, Sanusi KO, Ugusman A, Mohamed W, Kamal H, Ibrahim NH, et al. Alzheimer’s disease: an update and insights into pathophysiology. Front Aging Neurosci. 2022;14:742408.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Frisoni GB, Altomare D, Thal DR, Ribaldi F, Van Der Kant R, Ossenkoppele R, et al. The probabilistic model of Alzheimer disease: the amyloid hypothesis revised. Nat Rev Neurosci. 2022;23:53–66.

Article  CAS  PubMed  Google Scholar 

d’Errico P, Meyer-Luehmann M. Mechanisms of pathogenic tau and Aβ protein spreading in Alzheimer’s disease. Front Aging Neurosci. 2020;12:265.

Article  PubMed  PubMed Central  Google Scholar 

Zhang H, Wei W, Zhao M, Ma L, Jiang X, Pei H, et al. Interaction between Aβ and tau in the pathogenesis of Alzheimer’s disease. Int J Biol Sci. 2021;17:2181–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Simon DK, Tanner CM, Brundin P. Parkinson disease epidemiology, pathology, genetics, and pathophysiology. Clin Geriatr Med. 2020;36:1–12.

Article  PubMed  Google Scholar 

DeMaagd G, Philip A. Parkinson’s disease and its management: part 1: disease entity, risk factors, pathophysiology, clinical presentation, and diagnosis. P T. 2015;40:504–32.

PubMed  PubMed Central  Google Scholar 

Ebrahimi-Fakhari D, Saidi L-J, Wahlster L. Molecular chaperones and protein folding as therapeutic targets in Parkinson’s disease and other synucleinopathies. Acta Neuropathol Commun. 2013;1:79.

Article  PubMed  PubMed Central  Google Scholar 

Gómez-Benito M, Granado N, García-Sanz P, Michel A, Dumoulin M, Moratalla R. Modeling Parkinson’s disease with the alpha-synuclein protein. Front Pharmacol. 2020;11:356.

Article  PubMed  PubMed Central  Google Scholar 

Paxinou E, Chen Q, Weisse M, Giasson BI, Norris EH, Rueter SM, et al. Induction of α-synuclein aggregation by intracellular nitrative insult. J Neurosci. 2001;21:8053–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fields CR, Bengoa-Vergniory N, Wade-Martins R. Targeting alpha-synuclein as a therapy for Parkinson’s disease. Front Mol Neurosci. 2019;12:299.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McKeith I. Dementia with Lewy bodies. Dialogues Clin Neurosci. 2004;6:333–41.

Article  PubMed  PubMed Central  Google Scholar 

Outeiro TF, Koss DJ, Erskine D, Walker L, Kurzawa-Akanbi M, Burn D, et al. Dementia with Lewy bodies: an update and outlook. Mol Neurodegener. 2019;14:5.

Article  PubMed  PubMed Central  Google Scholar 

Haider A, Spurling BC, Sánchez-Manso JC. Lewy body dementia. In: StatPearls. Treasure Island: StatPearls Publishing; 2023. Available from: http://www.ncbi.nlm.nih.gov/books/NBK482441/. Cited 2024 Jan 5.

Kuhn J, Cascella M. Alexander disease. In: StatPearls. Treasure Island: StatPearls Publishing; 2023. Available from: http://www.ncbi.nlm.nih.gov/books/NBK562242/. Cited 2024 Jan 6.

Hagemann TL. Alexander disease: models, mechanisms, and medicine. Curr Opin Neurobiol. 2022;72:140–7.

Article  CAS  PubMed  Google Scholar 

Li W, Li J-Y. Overlaps and divergences between tauopathies and synucleinopathies: a duet of neurodegeneration. Transl Neurodegener. 2024;13:16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dugger BN, Dickson DW. Pathology of neurodegenerative diseases. Cold Spring Harb Perspect Biol. 2017;9:a028035.

Article  PubMed  PubMed Central  Google Scholar 

Blokhuis AM, Groen EJN, Koppers M, Van Den Berg LH, Pasterkamp RJ. Protein aggregation in amyotrophic lateral sclerosis. Acta Neuropathol. 2013;125:777–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hergesheimer RC, Chami AA, De Assis DR, Vourc’h P, Andres CR, Corcia P, et al. The debated toxic role of aggregated TDP-43 in amyotrophic lateral sclerosis: a resolution in sight? Brain. 2019;142:1176–94.

Article  PubMed  PubMed Central  Google Scholar 

Ortiz GG, Ramírez-Jirano J, Arizaga RL, Delgado-Lara DLC, Torres-Sánchez ED. Frontotemporal-TDP and LATE neurocognitive disorders: a pathophysiological and genetic approach. Brain Sci. 2023;13:1474.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bevan-Jones WR, Cope TE, Jones PS, Kaalund SS, Passamonti L, Allinson K, et al. Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum. Brain. 2020;143:1010–26.

Article  PubMed  PubMed Central  Google Scholar 

Jiao H-S, Yuan P, Yu J-T. TMEM106B aggregation in neurodegenerative diseases: linking genetics to function. Mol Neurodegener. 2023;18:54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Riku Y, Atsuta N, Yoshida M, Tatsumi S, Iwasaki Y, Mimuro M, et al. Differential motor neuron involvement in progressive muscular atrophy: a comparative study with amyotrophic lateral sclerosis. BMJ Open. 2014;4:e005213.

Article  PubMed  PubMed Central  Google Scholar 

Cykowski MD, Powell SZ, Appel JW, Arumanayagam AS, Rivera AL, Appel SH. Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis. Acta Neuropathol Commun. 2018;6:28.

Article  PubMed  PubMed Central  Google Scholar 

De Boer EMJ, Orie VK, Williams T, Baker MR, De Oliveira HM, Polvikoski T, et al. TDP-43 proteinopathies: a new wave of neurodegenerative diseases. J Neurol Neurosurg Psychiatry. 2021;92:86–95.

Article  Google Scholar 

Bayazid R, Orru’ C, Aslam R, Cohen Y, Silva-Rohwer A, Lee S-K, et al. A novel subtype of sporadic Creutzfeldt-Jakob disease with PRNP codon 129MM genotype and PrP plaques. Acta Neuropathol. 2023;146:121–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferrer I, Puig B, Blanco R, Martı E. Prion protein deposition and abnormal synaptic protein expression in the cerebellum in Creutzfeldt-Jakob disease. Neuroscience. 2000;97:715–26.

Article  CAS  PubMed 

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