Abdullah N, Chermahini SH, Suan CL, Sarmidi MR (2013) Labisia pumila: a review on its traditional, phytochemical and biological uses. World Appl Sci J 27:1297–1306. https://doi.org/10.5829/idosi.wasj.2013.27.10.1391

Aoki N, Arakawa E, Ito M (2007) Studies on anti-obesity effects of soy isoflavones with anti-oxidant and phytoestrogenic activity. Soy Protein Res 9:96–101

Google Scholar 

Arya P, Kumari N, Wani SA, Kumar P (2023) Trigonella foenum graecum In: Amalraj A, Karthik Varma AC, Kuttapan S, Matharu A (Eds) Herbs, spices and their roles in nutraceuticals and functional foods. Elsevier, London, pp 133–148. https://doi.org/10.1016/B978-0-323-90794-1.00001-6

Avula B, Wang YH, Ali Z, Smillie TJ, Khan IA (2010) Quantitative determination of triperpene saponins and alkenated-phenolics from Labisia pumila by LC-UV/ELSD method and confirmation by LC-ESI-TOF. Planta Med 77:1742–1748. https://doi.org/10.1055/s-0030-1271037

Article  CAS  Google Scholar 

Bahtiar A, Arifin S, Razalifha A, Qomariah N, Wuyung PE, Arsianti A (2014) Polar fraction of Punica granatum L. peel extract increased osteoblast number on ovariectomized rat bone. Int J Herb Med 2:65–70

Banerjee K, Thiagarajan P (2015) Linum usitatissimum L. (flax) plant and its seed oil a review. JCHPS 8:623–628

Bennetts HW, Underwood EJ (1951) The oestrogenic effects of subterranean clover (Trifolium subterraneum). Aust J Exp Biol Med Sci 29:249–253. https://doi.org/10.1038/icb.1951.29

Beral V, Banks E, Reeves G (2002) Evidence from randomised trials on the long-term effects of hormone replacement therapy. Lancet 360:942–944. https://doi.org/10.1016/S0140-6736(02)11032-4

Article  PubMed  Google Scholar 

Borker SA, Venugopalan PP, Bhat SN (2013) Study of menopausal symptoms, and perceptions about menopause among women at a rural community in Kerala. J Mid-Life Health 4:182–187. https://doi.org/10.4103/0976-7800.118997

Article  Google Scholar 

Carter MW, Smart WWG, Matrone G (1953) Estimation of estrogenic activity of genistein obtained from soybean meal. Proc Soc Exp Biol Med 84:506–507. https://doi.org/10.3181/00379727-84-20693

Article  CAS  PubMed  Google Scholar 

Cegieła U, Folwarczna J, Pytlik M, Zgórka G (2012) Effects of extracts from Trifolium medium L. and Trifolium pratense L. on development of estrogen deficiency-induced osteoporosis in rats. Evid-Based Compl Altern Med 2012:921684. https://doi.org/10.1155/2012/921684

Chansakaow S, Ishikawa T, Sekine K, Okada M, Higuchi Y, Kudo M, Chaichantipyuth C (2000) Isoflavonoids from Pueraria mirifica and their estrogenic activity. Planta Med 66:572–575. https://doi.org/10.1055/s-2000-8603

Article  CAS  PubMed  Google Scholar 

Cheng E, Story CD, Yoder L, Hale WH, Burroughs W (1953) Estrogenic activity of isoflavone derivatives extracted and prepared from soybean oil meal. Science 118:164–165. https://doi.org/10.1126/science.118.3058.164

Article  CAS  PubMed  Google Scholar 

Cherdshewasart W, Kitsamai Y, Malaivijitnond S (2007) Evaluation of the estrogenic activity of the wild Pueraria mirifica by vaginal cornification assay. J Reprod Dev 53:385–393. https://doi.org/10.1262/jrd.18065

Cherdshewasart W, Sriwatcharakul S, Malaivijitnond S (2008) Variance of estrogenic activity of the phytoestrogen-rich plant. Maturitas 61:350–357. https://doi.org/10.1016/j.maturitas.2008.09.017

Article  CAS  PubMed  Google Scholar 

Circosta C, Pasquale RD, Palumbo DR, Samperi S, Occhiuto F (2006) Effects of isoflavones from red clover (Trifolium pratense) on skin changes induced by ovariectomy in rats. Phytother Res 20:1096–1099. https://doi.org/10.1002/ptr.2017

Article  CAS  PubMed  Google Scholar 

Connor EB, Stuenkel CA (2001) Hormone replacement therapy (HRT)-risks and benefits. Int J Epidemiol 30:423–426. https://doi.org/10.1093/ije/30.3.423

Article  Google Scholar 

Curnow DH (1954) Oestrogenic activity of subterranean clover 2. The isolation of genistein from subterranean clover and methods of quantitative estimation. Biochem J 58:283–287. https://doi.org/10.1042/bj0580283

Article  CAS  PubMed  PubMed Central  Google Scholar 

Czepas JK (2016) Trifolium species – the latest findings on chemical profile, ethnomedicinal use and pharmacological properties. J Pharm Pharmacol 68:845–861. https://doi.org/10.1111/jphp.12568

Article  CAS  Google Scholar 

East J (1955) The effect of certain plant preparations on the fertility of laboratory mammals. J Endocrinol 12:261–266. https://doi.org/10.1677/joe.0.0120252

Article  CAS  PubMed  Google Scholar 

Echeverria V, Echeverria F, Barreto GE, Echeverría J, Mendoza C (2021) Estrogenic plants: to prevent neurodegeneration and memory loss and other symptoms in women after menopause. Front Pharmacol 12:644103. https://doi.org/10.3389/fphar.2021.644103

Article  CAS  PubMed  PubMed Central  Google Scholar 

Effendy NM, Khamis MF, Soelaiman IN, Shuid AN (2014) The effects of Labisia pumila on postmenopausal osteoporotic rat model: Dose and time-dependent micro-CT analysis. J X-Ray Sci Technol 22:503–518. https://doi.org/10.3233/XST-140441

Article  Google Scholar 

Elghamry MI, Grunert E, Schultz G (1969) Enlargement of the udders and milk secretion in nonpregnant heifers on pasture containing estrogenic plants. Deut Tierarztl Wochensch 76:445–448

CAS  Google Scholar 

Fait T (2019) Menopause hormone therapy: latest developments and clinical practice. Drugs Context 8:212551. https://doi.org/10.7573/dic.212551

Article  PubMed  PubMed Central  Google Scholar 

Fischer UA, Jaksch AV, Carle R, Kammerer DR (2012) Determination of lignans in edible and nonedible parts of pomegranate (Punica granatum L.) and products derived therefrom, particularly focusing on the quantitation of isolariciresinol using HPLC-DAD-ESI/MSn. J Agric Food Chem 60:283–292. https://doi.org/10.1021/jf203598m

Flux DS, Munford RE, Wilson GF (1963) Biological estimation of oestrogenic activity in red clover (Trifolium pratense): relative potencies of parts of plant and changes with storage. J Dairy Res 30:243–249. https://doi.org/10.1017/S0022029900011432

Franke AA, Halm BM, Kakazu K, Li X, Custer LJ (2009) Phytoestrogenic isoflavonoids in epidemiologic and clinical research. Drug Test Anal 1:14–21. https://doi.org/10.1002/dta.12

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fuentealba C, Figuerola F, Estevez AM, Bastias JM, Munoz O (2014) Bioaccessibility of lignans from flaxseed (Linum usitatissimum L.) determined by single-batch in vitro simulation of the digestive process. J Sci Food Agric 94:1729–1738. https://doi.org/10.1002/jsfa.6482

Hargreaves DF, Potten CS, Harding C, Shaw LE, Morton MS, Roberts SA, Howell A, Bundred NJ (1999) Two-week dietary soy supplementation has an estrogenic effect on normal premenopausal breast. J Clin Endocrinol Metab 84:4017–4024. https://doi.org/10.1210/jcem.84.11.6152

Article  CAS  PubMed  Google Scholar 

Hettle JA, Kitts WD (1983) Effects of phyto-estrogenic alfalfa consumption on plasma LH levels in cycling ewes. Anim Reprod Sci 6:233–238. https://doi.org/10.1016/0378-4320(83)90043-X

Article  CAS  Google Scholar 

Hiremath SP, Rao SH (1990) Antifertility efficacy of the plant Striga lutea (Scrophulariacae) on rats. Contraception 42:467–477. https://doi.org/10.1016/0010-7824(90)90053-X

Hong YH, Wang SC, Hsu C, Lin BF, Kuo YH, Huang CJ (2011) Phytoestrogenic compounds in alfalfa sprout (Medicago sativa) beyond coumestrol. J Agric Food Chem 59:131–137. https://doi.org/10.1021/jf102997p

Kalachaveedu M, Raghavan D, Telapolu S, Kuruvilla S, Kedike B (2018) Phytoestrogenic effect of Inula racemosa Hook f – a cardioprotective root drug in traditional medicine. J Ethnopharmacol 210:408–416. https://doi.org/10.1016/j.jep.2017.09.001

Kasparova M, Siatka T, Spilkova J, Dusek JC (2006) Explant culture of Trifolium pratense L. Farmaceuticke Spolecnosti 55:44–47

Khushboo PS, Jadhav VM, Kadam VJ, Sathe NS (2010) Psoralea corylifolia Linn. –“Kushtanashini.” Pharmacogn Rev 4:69–76. https://doi.org/10.4103/0973-7847.65331

Kim MH, Choi YY, Han JM, Lee HS, Hong SB, Lee SG, Yang WM (2014) Ameliorative effects of Schizandra chinensis on osteoporosis via activation of estrogen receptor (ER)-α/-β. Food Funct 5:1594–1601. https://doi.org/10.1039/c4fo00133h

Kim MH, Lee HS, Hong SB, Yang WM (2017) Schizandra chinensis exhibits phytoestrogenic effects by regulating the activation of estrogen receptor-α and-β. Chin J Integr Med. https://doi.org/10.1007/s11655-017-2966-y

Louw A, Joubert E, Visser K (2013) Phytoestrogenic potential of Cyclopia extracts and polyphenols. Planta Med 79:580–590. https://doi.org/10.1055/s-0032-1328463

Article  CAS  PubMed  Google Scholar 

Lu LJW, Chen NW, Nayeem F, Ramanujam VMS, Kuo YF, Brunder DG, Nagamani M, Anderson KE (2018) Novel effects of phytoestrogenic soy isoflavones on serum calcium and chloride in premenopausal women: a 2-year double-blind, randomized, placebo-controlled study. Clin Nutr 37:1862–1870. https://doi.org/10.1016/j.clnu.2017.11.002

Article  CAS  PubMed  Google Scholar 

Maggiolini M, Statti G, Vivacqua A, Gabriele S, Rago V, Loizzo M, Menichini F, Amdò S (2002) Estrogenic and antiproliferative activities of isoliquiritigenin in MCF7 breast cancer cells. J Steroid Biochem Mol Biol 82:315–322. https://doi.org/10.1016/S0960-0760(02)00230-3

Article  CAS  PubMed  Google Scholar 

Mahajan N, Aggarwal M, Bagga A (2012) Health issues of menopausal women in North India. J mid-Life Health 3:84–87. https://doi.org/10.4103/0976-7800.104467

Article  Google Scholar 

Martinchik AN, Zubtsov VV (2012) Phyto-estrogenic properties of flaxseed lignans. Vopr Pitan 81:61–66

CAS  PubMed  Google Scholar 

Messina M (2014) Soy foods, isoflavones, and the health of postmenopausal women. Am J Clin Nutr 100:423S-430S. https://doi.org/10.3945/ajcn.113.071464

Article  CAS  PubMed  Google Scholar 

Mfenyana C, DeBeer D, Joubert E, Louw A (2008) Selective extraction of Cyclopia for enhanced in vitro phytoestrogenicity and benchmarking against commercial phytoestrogen extracts. J Steroid Biochem Mol Biol 112:74–86. https://doi.org/10.1016/j.jsbmb.2008.08.005

Milligan S, Ka