Barbaro RP, MacLaren G, Boonstra PS, Combes A, Agerstrand C, Annich G, Diaz R, Fan E, Hryniewicz K, Lorusso R, Paden ML, Stead CM, Swol J, Iwashyna TJ, Slutsky AS, Brodie D, for the Extracorporeal Life Support Organization. Extracorporeal membrane oxygenation for COVID-19: evolving outcomes from the International Extracorporeal Life Support Organization Registry. Lancet. 2021;398:1230–8. https://doi.org/10.1016/S0140-6736(21)01960-7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ogura T, Oshimo S, Liu K, Iwashita Y, Hashimoto S, Takeda S. Establishment of a disaster management-like system for COVID-19 patients requiring veno-venous extracorporeal membrane oxygenation in Japan. Membranes. 2021;11:625. https://doi.org/10.3390/membranes11080625.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fukuda M, Tanaka R, Sadano K, Tokumine A, Mori T, Saomoto H, Sakai K. Insights into gradient and anisotropic pore structures of Capiox® gas exchange membranes for ECMO: theoretically verifying SARS-CoV-2 permeability. Membranes. 2022;12:314. https://doi.org/10.3390/membranes12030314.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ogawa T, Uemura T, Matsuda W, Sato M, Ishizuka K, Fukaya T, Kinoshita N, Nakamoto T, Ohmagari N, Katano H, Suzuki T, Hosaka S. SARS-CoV-2 leakage from the gas outlet port during extracorporeal membrane oxygenation for COVID-19. ASAIO J. 2021;67:511–6. https://doi.org/10.1097/MAT.0000000000001402.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fukuda M. Evolutions of extracorporeal membrane oxygenator (ECMO): perspectives for advanced hollow fiber membrane. J Artif Organs. 2024;27:1–6. https://doi.org/10.1007/s10047-023-01389-w.

Article  CAS  PubMed  Google Scholar 

Wang Y, Liu Y, Han Q, Lin H, Liu F. A novel poly (4-methyl-1-pentene)/polypropylene (PMP/PP) thin film composite (TFC) artificial lung membrane for enhanced gas transport and excellent hemo-compatibility. J Membr Sci. 2022;649:120359. https://doi.org/10.1016/j.memsci.2022.120359.

Article  CAS  Google Scholar 

Feng Y, Wang Q, Zhi L, Sun S, Zhao C. Anticoagulant biomimetic consecutive gas exchange network for advanced artificial lung membrane. J Membr Sci. 2022;653:1205029. https://doi.org/10.1016/j.memsci.2022.120502.

Article  CAS  Google Scholar 

Zhang T-Q, Jia Z-Q, Peng W, Li S, Wen J. Preparation of 4-methyl-1-pentene membranes via non-solvent induced phase separation (NIPS). Eur Polym J. 2022;178:111480. https://doi.org/10.1016/j.eurpolymj.2022.111480.

Article  CAS  Google Scholar 

Sheng D, Zhang L, Jia H, Guo B, Zhang X, Li Y. Phosphorylcholine/heparin composite coatings on artificial lung membrane for enhanced hemo-compatibility. Langmuir. 2023;653:1205029. https://doi.org/10.1021/acs.langmuir.3c00945.

Article  CAS  Google Scholar 

Feng Y, Wang Q, Sun S, Zhao W, Zhao C. Advanced hemocompatible polyethersulfone composite artificial lung membrane with efficient CO2/O2 exchange channel constructed by modified carbon nanotubes network. J Mater Sci Technol. 2023;160:181–93. https://doi.org/10.1016/j.jmst.2023.02.060.

Article  CAS  Google Scholar 

He T, He J, Wang Z, Cui Z. Modification strategies to improve the membrane hemocompatibility in extracorporeal membrane oxygenator (ECMO). Adv Compos Hybrid Mater. 2021;4:847–64. https://doi.org/10.1007/s42114-021-00244-x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barbaro RP, MacLaren G, Boonstra PS, Chen D, Li J, Hu H, Zhong X, Wang Y, Wang Z, Cui Z. Extracorporeal membrane oxygenator (ECMO): history, preparation, modification and mass transfer. Chin J Chem Eng. 2022;49:46–75.

Article  Google Scholar 

Tang Y, Zhang F, Wu F, Wang L, Feng A, Yu L, Wu H, Lin Y, Wang X. A novel tunable polypropylene hollow fiber membrane with gradient structure for extracorporeal membrane oxygenation applications. J Membr Sci. 2024;693:122325. https://doi.org/10.1016/j.memsci.2023.120502.

Article  CAS  Google Scholar 

Duy Nguyen BT, Nguyen Thi HY, Nguyen Thi BP, Kang D-K, Kim JF. The roles of membrane technology in artificial organs: current challenges and perspectives. Membranes. 2021;11:239. https://doi.org/10.3390/membranes11040239.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fukuda M, Furuya T, Sadano K, Tokumine A, Mori T, Saomoto H, Sakai K. Electron microscopic confirmation of anisotropic pore characteristics for ECMO membranes theoretically validating the risk of SARS-CoV-2 permeation. Membranes. 2021;11:529. https://doi.org/10.3390/membranes11070529.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fukuda M, Yoshimoto H, Saomoto H, Sakai K. Validity of three-dimensional tortuous pore structure and fouling of hemoconcentration capillary membrane using tortuous pore diffusion model and scanning probe microscopy. Membranes. 2020;10:315. https://doi.org/10.3390/membranes10110315.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hayama M, Kohori F, Sakai K. AFM observation of small surface pores of hollow fiber dialysis membrane using highly sharpened probe. J Membr Sci. 2002;197:243–9.

Article  CAS  Google Scholar 

Yamazaki K, Matsuda M, Yamamoto K, Yakushiji T, Sakai K. Internal and surface structure characterization of cellulose triacetate hollow fiber dialysis membranes. J Membr Sci. 2011;368:34–40. https://doi.org/10.1016/j.memsci.2010.11.008.

Article  CAS  Google Scholar 

Fukuda M, Saomoto H, Mori T, Yoshimoto H, Kusumi R, Sakai K. Impact of three-dimensional tortuous pore structure on polyethersulfone membrane morphology and mass transfer properties from a manufacturing perspective. J Artif Organs. 2020;23:171–9. https://doi.org/10.1007/s10047-019-01144-0.

Article  CAS  PubMed  Google Scholar 

Alqaheem Y, Alomair AA. Microscopy and spectroscopy techniques for characterization of polymeric membranes. Membranes. 2020;10:33. https://doi.org/10.3390/membranes10020033.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dinelli F, Brucale M, Valle F, Ascoli C, Samorì B, Sartore M, Adami M, Galletti R, Prato S, Troian B, Albonetti C. Probing Italy: a scanning probe microscopy storyline. Micro. 2023;3:549–65. https://doi.org/10.3390/mico3020037.

Article  Google Scholar 

Fukuda M, Sakai K. 3D porous structure imaging of membranes for medical devices using scanning probe microscopy and electron microscopy—from membrane science points of view. J Artif Organs. 2024. https://doi.org/10.1007/s10047-023-01431-x.

Article  PubMed  Google Scholar 

Ren H, Zhang X, Li Y, Zhang D, Huang F, Zhang Z. Preparation of cross-sectional membrane samples for scanning electron microscopy characterizations using a new frozen section technique. Membranes. 2023;13:634. https://doi.org/10.3390/membranes13070634.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roberge H, Moreau P, Couallier E, Abella P. Determination of the key structural factors affecting permeability and selectivity of PAN and PES polymeric filtration membranes using 3D FIB/SEM. J Membr Sci. 2022;653:120530. https://doi.org/10.1016/j.memsci.2022.120530.

Article  CAS  Google Scholar 

Kaneko A, Takasu H. Introduction of ion milling system and its application (in Japanese). J Surf Finish Soc Jpn. 2015;66:581–5. https://doi.org/10.4139/sfj.66.581.

Article  Google Scholar 

Getinge Group Japan K.K. Package insert (assisting circulation system: HLS SET Advanced-LT, 30200BZX00270000), 22 May 2023

Terumo Corporation. https://www.terumo.co.jp/medical/equipment/me171.html. Accessed 1 Nov 2023

Tatsumi E, Taenaka Y, Nakatani T, Akagi H, Seki H, Yagura A, Sasaki E, Goto M, Nakamaru H, Takano H. A VAD and novel high performance compact oxygenator for long-term ECMO with local anticoagulation. ASAIO J. 1990;36:M480–3.

CAS  Google Scholar 

Tanaka M, Motomura T, Kawada M, Anzai T, Kasori Y, Shiroya T, Shimura K, Onishi M, Mochizuki A. Blood compatible aspects of poly(2-methoxyethylacrylate) (PMEA)-relationship between protein adsorption and platelet adhesion on PMEA surface. Biomaterials. 2000;21:1471–81.

Article  CAS  PubMed  Google Scholar 

Lund LW, Hattler BG, Federspiel WJ. Is condensation the cause of plasma leakage in microporous hollow fiber membrane oxygenators. J Membr Sci. 1998;147:87–93.

Article