Esposito, M., Guise, T. & Kang, Y. The biology of bone metastasis. Cold Spring Harb. Perspect. Med. 8, a031252 (2018).
Article PubMed PubMed Central Google Scholar
Zhang, W. et al. The bone microenvironment invigorates metastatic seeds for further dissemination. Cell 184, 2471–2486.e20 (2021).
Article CAS PubMed PubMed Central Google Scholar
Nagrath, S. et al. Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature 450, 1235–1239 (2007).
Article CAS PubMed PubMed Central Google Scholar
Braun, S. et al. A pooled analysis of bone marrow micrometastasis in breast cancer. N. Engl. J. Med. 353, 793–802 (2005).
Article CAS PubMed Google Scholar
Zheng, H. et al. Therapeutic antibody targeting tumor- and osteoblastic niche-derived Jagged1 sensitizes bone metastasis to chemotherapy. Cancer Cell 32, 731–747.e6 (2017).
Article CAS PubMed PubMed Central Google Scholar
Wang, H. et al. The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells. Cancer Cell 27, 193–210 (2015).
Article PubMed PubMed Central Google Scholar
Lu, X. et al. VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors. Cancer Cell 20, 701–714 (2011).
Article CAS PubMed PubMed Central Google Scholar
Ghajar, C. M. et al. The perivascular niche regulates breast tumour dormancy. Nat. Cell Biol. 15, 807–817 (2013).
Article CAS PubMed PubMed Central Google Scholar
Yin, J. J. et al. TGF-β signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. J. Clin. Invest. 103, 197–206 (1999).
Article CAS PubMed PubMed Central Google Scholar
Ross, M. H. et al. Bone-induced expression of integrin β3 enables targeted nanotherapy of breast cancer metastases. Cancer Res. 77, 6299–6312 (2017).
Article CAS PubMed PubMed Central Google Scholar
Sethi, N., Dai, X., Winter, C. G. & Kang, Y. Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. Cancer Cell 19, 192–205 (2011).
Article CAS PubMed PubMed Central Google Scholar
Satcher, R. L. & Zhang, X. H. Evolving cancer-niche interactions and therapeutic targets during bone metastasis. Nat. Rev. Cancer 22, 85–101 (2022).
Article CAS PubMed Google Scholar
Massague, J. & Obenauf, A. C. Metastatic colonization by circulating tumour cells. Nature 529, 298–306 (2016).
Article CAS PubMed PubMed Central Google Scholar
Minn, A. J. et al. Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. J. Clin. Invest. 115, 44–55 (2005).
Article CAS PubMed PubMed Central Google Scholar
Kang, Y. et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3, 537–549 (2003).
Article CAS PubMed Google Scholar
Lelekakis, M. et al. A novel orthotopic model of breast cancer metastasis to bone. Clin. Exp. Metastasis 17, 163–170 (1999).
Article CAS PubMed Google Scholar
Navin, N. et al. Tumour evolution inferred by single-cell sequencing. Nature 472, 90–94 (2011).
Article CAS PubMed PubMed Central Google Scholar
Picelli, S. et al. Full-length RNA-seq from single cells using Smart-seq2. Nat. Protoc. 9, 171–181 (2014).
Article CAS PubMed Google Scholar
Wang, X. L., He, Y., Zhang, Q. M., Ren, X. W. & Zhang, Z. M. Direct comparative analyses of 10X Genomics chromium and Smart-seq2. Genom. Proteom. Bioinf. 19, 253–266 (2021).
Reid, J. E. & Wernisch, L. Pseudotime estimation: deconfounding single cell time series. Bioinformatics 32, 2973–2980 (2016).
Article CAS PubMed PubMed Central Google Scholar
Jolly, M. K., Ware, K. E., Gilja, S., Somarelli, J. A. & Levine, H. EMT and MET: necessary or permissive for metastasis? Mol. Oncol. 11, 755–769 (2017).
Article PubMed PubMed Central Google Scholar
Thiery, J. P., Acloque, H., Huang, R. Y. & Nieto, M. A. Epithelial–mesenchymal transitions in development and disease. Cell 139, 871–890 (2009).
Article CAS PubMed Google Scholar
Minn, A. J. et al. Genes that mediate breast cancer metastasis to lung. Nature 436, 518–524 (2005).
Article CAS PubMed PubMed Central Google Scholar
Lanczky, A. & Gyorffy, B. Web-based survival analysis tool tailored for medical research (KMplot): development and implementation. J. Med. Internet Res. 23, e27633 (2021).
Article PubMed PubMed Central Google Scholar
Rose, A. A. et al. Osteoactivin promotes breast cancer metastasis to bone. Mol. Cancer Res. 5, 1001–1014 (2007).
Article CAS PubMed Google Scholar
Maric, G., Rose, A. A., Annis, M. G. & Siegel, P. M. Glycoprotein non-metastatic b (GPNMB): a metastatic mediator and emerging therapeutic target in cancer. Onco Targets Ther. 6, 839–852 (2013).
CAS PubMed PubMed Central Google Scholar
Tang, X. et al. GPR116, an adhesion G-protein-coupled receptor, promotes breast cancer metastasis via the Gαq-p63RhoGEF-Rho GTPase pathway. Cancer Res. 73, 6206–6218 (2013).
Article CAS PubMed Google Scholar
Lu, T. T. & Browning, J. L. Role of the lymphotoxin/LIGHT system in the development and maintenance of reticular networks and vasculature in lymphoid tissues. Front. Immunol. 5, 47 (2014).
Article PubMed PubMed Central Google Scholar
Haybaeck, J. et al. A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell 16, 295–308 (2009).
Article CAS PubMed PubMed Central Google Scholar
Bauer, J. et al. Lymphotoxin, NF-kB, and cancer: the dark side of cytokines. Dig. Dis. 30, 453–468 (2012).
Das, R. et al. Lymphotoxin-β receptor–NIK signaling induces alternative RELB/NF-κB2 activation to promote metastatic gene expression and cell migration in head and neck cancer. Mol. Carcinog. 58, 411–425 (2019).
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