Mesenchymal stem cells-derived exosomes alleviate liver fibrosis by targeting Hedgehog/SMO signaling

Parola M, Pinzani M. Liver fibrosis: pathophysiology, pathogenetic targets and clinical issues. Mol Aspects Med. 2019;65:37–55

Article  CAS  PubMed  Google Scholar 

Yan Y, et al. Extra- and intra-cellular mechanisms of hepatic stellate cell activation. Biomedicines. 2021;9(8):1014

Article  PubMed  PubMed Central  Google Scholar 

Kisseleva T, Brenner D. Molecular and cellular mechanisms of liver fibrosis and its regression. Nat Rev Gastroenterol Hepatol. 2021;18(3):151–166

Article  PubMed  Google Scholar 

Friedman SL. Liver fibrosis–from bench to bedside. J Hepatol. 2003;38(1):S38-53

Article  PubMed  Google Scholar 

Tsuchida T, Friedman SL. Mechanisms of hepatic stellate cell activation. Nat Rev Gastroenterol Hepatol. 2017;14(7):397–411

Article  CAS  PubMed  Google Scholar 

Higashi T, Friedman SL, Hoshida Y. Hepatic stellate cells as key target in liver fibrosis. Adv Drug Deliv Rev. 2017;121:27–42

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lackner C, Tiniakos D. Fibrosis and alcohol-related liver disease. J Hepatol. 2019;70(2):294–304

Article  PubMed  Google Scholar 

Weng Z, et al. Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer. J Hematol Oncol. 2021;14(1):136

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang W, et al. Comparison of therapeutic effects of mesenchymal stem cells from umbilical cord and bone marrow in the treatment of type 1 diabetes. Stem Cell Res Ther. 2022;13(1):406

Article  PubMed  PubMed Central  Google Scholar 

Kern S, et al. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells. 2006;24(5):1294–1301

Article  CAS  PubMed  Google Scholar 

Wang Y, et al. Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications. Nat Immunol. 2014;15(11):1009–1016

Article  CAS  PubMed  Google Scholar 

Li C, et al. Hippo signaling controls NLR family pyrin domain containing 3 activation and governs immunoregulation of mesenchymal stem cells in mouse liver injury. Hepatology. 2019;70(5):1714–1731

Article  CAS  PubMed  Google Scholar 

Yu M, et al. Notch-activated mesenchymal stromal/stem cells enhance the protective effect against acetaminophen-induced acute liver injury by activating AMPK/SIRT1 pathway. Stem Cell Res Ther. 2022;13(1):318

Article  CAS  PubMed  PubMed Central  Google Scholar 

El Agha E, et al. Mesenchymal stem cells in fibrotic disease. Cell Stem Cell. 2017;21(2):166–177

Article  PubMed  Google Scholar 

Trounson A, McDonald C. Stem cell therapies in clinical trials: progress and challenges. Cell Stem Cell. 2015;17(1):11–22

Article  CAS  PubMed  Google Scholar 

Wan T, et al. Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases. Sci Adv. 2022;8(37):eabp9435

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie Z, et al. Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment. Gut. 2022;71(3):568–579

Article  CAS  PubMed  Google Scholar 

Hou X, et al. Myeloid-cell-specific IL-6 signaling promotes microRNA-223-enriched exosome production to attenuate NAFLD-associated fibrosis. Hepatology. 2021;74(1):116–132

Article  CAS  PubMed  Google Scholar 

Vlassov AV, et al. Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochim Biophys Acta. 2012;1820(7):940–948

Article  CAS  PubMed  Google Scholar 

Greening DW, et al. Exosomes and their roles in immune regulation and cancer. Semin Cell Dev Biol. 2015;40:72–81

Article  CAS  PubMed  Google Scholar 

Kinoshita K, et al. Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats. Gut. 2007;56(5):706–714

Article  CAS  PubMed  Google Scholar 

Omenetti A, et al. Hedgehog signaling in the liver. J Hepatol. 2011;54(2):366–373

Article  CAS  PubMed  Google Scholar 

Du K, et al. Hedgehog-YAP signaling pathway regulates glutaminolysis to control activation of hepatic stellate cells. Gastroenterology. 2018;154(5):1465–1479

Article  CAS  PubMed  Google Scholar 

Swiderska-Syn M, et al. Hedgehog regulates yes-associated protein 1 in regenerating mouse liver. Hepatology. 2016;64(1):232–244

Article  CAS  PubMed  Google Scholar 

Machado MV, Diehl AM. Hedgehog signalling in liver pathophysiology. J Hepatol. 2018;68(3):550–562

Article  CAS  PubMed  Google Scholar 

Tong G, et al. Fibroblast growth factor 18 attenuates liver fibrosis and HSCs activation via the SMO-LATS1-YAP pathway. Pharmacol Res. 2022;178:106139

Article  CAS  PubMed  Google Scholar 

Briscoe J, Therond PP. The mechanisms of Hedgehog signalling and its roles in development and disease. Nat Rev Mol Cell Biol. 2013;14(7):416–429

Article  PubMed  Google Scholar 

Bhave VS, et al. Regulation of liver growth by glypican 3, CD81, hedgehog, and Hhex. Am J Pathol. 2013;183(1):153–159

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Y, et al. Hedgehog controls hepatic stellate cell fate by regulating metabolism. Gastroenterology. 2012;143(5):1319–1329

Article  CAS  PubMed  Google Scholar 

Kramann R, Schneider RK. The identification of fibrosis-driving myofibroblast precursors reveals new therapeutic avenues in myelofibrosis. Blood. 2018;131(19):2111–2119

Article  CAS  PubMed  Google Scholar 

Huang Y, et al. Single cell transcriptomic analysis of human mesenchymal stem cells reveals limited heterogeneity. Cell Death Dis. 2019;10(5):368

Article  PubMed  PubMed Central  Google Scholar 

Lin Y, et al. Huc-MSC-derived exosomes modified with the targeting peptide of aHSCs for liver fibrosis therapy. J Nanobiotechnol. 2022;20(1):432

Article  CAS  Google Scholar 

Heo JS, Kim S. Human adipose mesenchymal stem cells modulate inflammation and angiogenesis through

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