Parola M, Pinzani M. Liver fibrosis: pathophysiology, pathogenetic targets and clinical issues. Mol Aspects Med. 2019;65:37–55
Article CAS PubMed Google Scholar
Yan Y, et al. Extra- and intra-cellular mechanisms of hepatic stellate cell activation. Biomedicines. 2021;9(8):1014
Article PubMed PubMed Central Google Scholar
Kisseleva T, Brenner D. Molecular and cellular mechanisms of liver fibrosis and its regression. Nat Rev Gastroenterol Hepatol. 2021;18(3):151–166
Friedman SL. Liver fibrosis–from bench to bedside. J Hepatol. 2003;38(1):S38-53
Tsuchida T, Friedman SL. Mechanisms of hepatic stellate cell activation. Nat Rev Gastroenterol Hepatol. 2017;14(7):397–411
Article CAS PubMed Google Scholar
Higashi T, Friedman SL, Hoshida Y. Hepatic stellate cells as key target in liver fibrosis. Adv Drug Deliv Rev. 2017;121:27–42
Article CAS PubMed PubMed Central Google Scholar
Lackner C, Tiniakos D. Fibrosis and alcohol-related liver disease. J Hepatol. 2019;70(2):294–304
Weng Z, et al. Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer. J Hematol Oncol. 2021;14(1):136
Article CAS PubMed PubMed Central Google Scholar
Zhang W, et al. Comparison of therapeutic effects of mesenchymal stem cells from umbilical cord and bone marrow in the treatment of type 1 diabetes. Stem Cell Res Ther. 2022;13(1):406
Article PubMed PubMed Central Google Scholar
Kern S, et al. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells. 2006;24(5):1294–1301
Article CAS PubMed Google Scholar
Wang Y, et al. Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications. Nat Immunol. 2014;15(11):1009–1016
Article CAS PubMed Google Scholar
Li C, et al. Hippo signaling controls NLR family pyrin domain containing 3 activation and governs immunoregulation of mesenchymal stem cells in mouse liver injury. Hepatology. 2019;70(5):1714–1731
Article CAS PubMed Google Scholar
Yu M, et al. Notch-activated mesenchymal stromal/stem cells enhance the protective effect against acetaminophen-induced acute liver injury by activating AMPK/SIRT1 pathway. Stem Cell Res Ther. 2022;13(1):318
Article CAS PubMed PubMed Central Google Scholar
El Agha E, et al. Mesenchymal stem cells in fibrotic disease. Cell Stem Cell. 2017;21(2):166–177
Trounson A, McDonald C. Stem cell therapies in clinical trials: progress and challenges. Cell Stem Cell. 2015;17(1):11–22
Article CAS PubMed Google Scholar
Wan T, et al. Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases. Sci Adv. 2022;8(37):eabp9435
Article CAS PubMed PubMed Central Google Scholar
Xie Z, et al. Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment. Gut. 2022;71(3):568–579
Article CAS PubMed Google Scholar
Hou X, et al. Myeloid-cell-specific IL-6 signaling promotes microRNA-223-enriched exosome production to attenuate NAFLD-associated fibrosis. Hepatology. 2021;74(1):116–132
Article CAS PubMed Google Scholar
Vlassov AV, et al. Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochim Biophys Acta. 2012;1820(7):940–948
Article CAS PubMed Google Scholar
Greening DW, et al. Exosomes and their roles in immune regulation and cancer. Semin Cell Dev Biol. 2015;40:72–81
Article CAS PubMed Google Scholar
Kinoshita K, et al. Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats. Gut. 2007;56(5):706–714
Article CAS PubMed Google Scholar
Omenetti A, et al. Hedgehog signaling in the liver. J Hepatol. 2011;54(2):366–373
Article CAS PubMed Google Scholar
Du K, et al. Hedgehog-YAP signaling pathway regulates glutaminolysis to control activation of hepatic stellate cells. Gastroenterology. 2018;154(5):1465–1479
Article CAS PubMed Google Scholar
Swiderska-Syn M, et al. Hedgehog regulates yes-associated protein 1 in regenerating mouse liver. Hepatology. 2016;64(1):232–244
Article CAS PubMed Google Scholar
Machado MV, Diehl AM. Hedgehog signalling in liver pathophysiology. J Hepatol. 2018;68(3):550–562
Article CAS PubMed Google Scholar
Tong G, et al. Fibroblast growth factor 18 attenuates liver fibrosis and HSCs activation via the SMO-LATS1-YAP pathway. Pharmacol Res. 2022;178:106139
Article CAS PubMed Google Scholar
Briscoe J, Therond PP. The mechanisms of Hedgehog signalling and its roles in development and disease. Nat Rev Mol Cell Biol. 2013;14(7):416–429
Bhave VS, et al. Regulation of liver growth by glypican 3, CD81, hedgehog, and Hhex. Am J Pathol. 2013;183(1):153–159
Article CAS PubMed PubMed Central Google Scholar
Chen Y, et al. Hedgehog controls hepatic stellate cell fate by regulating metabolism. Gastroenterology. 2012;143(5):1319–1329
Article CAS PubMed Google Scholar
Kramann R, Schneider RK. The identification of fibrosis-driving myofibroblast precursors reveals new therapeutic avenues in myelofibrosis. Blood. 2018;131(19):2111–2119
Article CAS PubMed Google Scholar
Huang Y, et al. Single cell transcriptomic analysis of human mesenchymal stem cells reveals limited heterogeneity. Cell Death Dis. 2019;10(5):368
Article PubMed PubMed Central Google Scholar
Lin Y, et al. Huc-MSC-derived exosomes modified with the targeting peptide of aHSCs for liver fibrosis therapy. J Nanobiotechnol. 2022;20(1):432
Heo JS, Kim S. Human adipose mesenchymal stem cells modulate inflammation and angiogenesis through
留言 (0)