Barthwal MK, Anzinger JJ, Xu Q, Bohnacker T, Wymann MP, Kruth HS (2013) Fluid-phase pinocytosis of native low density lipoprotein promotes murine M-CSF differentiated macrophage foam cell formation. PLoS ONE 8:e58054. https://doi.org/10.1371/journal.pone.0058054

Article  CAS  PubMed  PubMed Central  Google Scholar 

Buono C, Anzinger JJ, Amar M, Kruth HS (2009) Fluorescent pegylated nanoparticles demonstrate fluid-phase pinocytosis by macrophages in mouse atherosclerotic lesions. J Clin Invest 119:1373–1381. https://doi.org/10.1172/JCI35548

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao B, Li Y, Buono C, Waldo SW, Jones NL, Mori M, Kruth HS (2006) Constitutive receptor-independent low density lipoprotein uptake and cholesterol accumulation by macrophages differentiated from human monocytes with macrophage-colony-stimulating factor (M-CSF). J Biol Chem 281:15757–15762. https://doi.org/10.1074/jbc.M510714200

Article  CAS  PubMed  Google Scholar 

Zhang F, Guo X, Xia Y, Mao L (2021) An update on the phenotypic switching of vascular smooth muscle cells in the pathogenesis of atherosclerosis. Cell Mol Life Sci 79:6. https://doi.org/10.1007/s00018-021-04079-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hotamisligil GS (2010) Endoplasmic reticulum stress and atherosclerosis. Nat Med 16:396–399. https://doi.org/10.1038/nm0410-396

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo X, Li B, Wen C, Zhang F, Xiang X, Nie L, Chen J, Mao L (2023) TREM2 promotes cholesterol uptake and foam cell formation in atherosclerosis. Cell Mol Life Sci 80:137. https://doi.org/10.1007/s00018-023-04786-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brophy ML, Dong Y, Wu H, Rahman HN, Song K, Chen H (2017) Eating the dead to keep atherosclerosis at bay. Front Cardiovasc Med 4:2. https://doi.org/10.3389/fcvm.2017.00002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang S, Weinberg S, DeBerge M, Gainullina A, Schipma M, Kinchen JM, Ben-Sahra I, Gius DR, Yvan-Charvet L, Chandel NS, Schumacker PT, Thorp EB (2019) Efferocytosis fuels requirements of fatty acid oxidation and the electron transport chain to polarize macrophages for tissue repair. Cell Metab 29:443-456 e445. https://doi.org/10.1016/j.cmet.2018.12.004

Article  CAS  PubMed  Google Scholar 

Kojima Y, Volkmer JP, McKenna K, Civelek M, Lusis AJ, Miller CL, Direnzo D, Nanda V, Ye J, Connolly AJ, Schadt EE, Quertermous T, Betancur P, Maegdefessel L, Matic LP, Hedin U, Weissman IL, Leeper NJ (2016) CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature 536:86–90. https://doi.org/10.1038/nature18935

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang J, Lobatto ME, Hassing L, van der Staay S, van Rijs SM, Calcagno C, Braza MS, Baxter S, Fay F, Sanchez-Gaytan BL, Duivenvoorden R, Sager H, Astudillo YM, Leong W, Ramachandran S, Storm G, Perez-Medina C, Reiner T, Cormode DP, Strijkers GJ, Stroes ES, Swirski FK, Nahrendorf M, Fisher EA, Fayad ZA, Mulder WJ (2015) Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation. Sci Adv. https://doi.org/10.1126/sciadv.1400223

Article  PubMed  PubMed Central  Google Scholar 

Feil S, Fehrenbacher B, Lukowski R, Essmann F, Schulze-Osthoff K, Schaller M, Feil R (2014) Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis. Circ Res 115:662–667. https://doi.org/10.1161/CIRCRESAHA.115.304634

Article  CAS  PubMed  Google Scholar 

Wong TY, Juang WC, Tsai CT, Tseng CJ, Lee WH, Chang SN, Cheng PW (2018) Mechanical stretching simulates cardiac physiology and pathology through mechanosensor Piezo1. J Clin Med. https://doi.org/10.3390/jcm7110410

Article  PubMed  PubMed Central  Google Scholar 

Cahalan SM, Lukacs V, Ranade SS, Chien S, Bandell M, Patapoutian A (2015) Piezo1 links mechanical forces to red blood cell volume. Elife. https://doi.org/10.7554/eLife.07370

Article  PubMed  PubMed Central  Google Scholar 

Solis AG, Bielecki P, Steach HR, Sharma L, Harman CCD, Yun S, de Zoete MR, Warnock JN, To SDF, York AG, Mack M, Schwartz MA, Dela Cruz CS, Palm NW, Jackson R, Flavell RA (2019) Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity. Nature 573:69–74. https://doi.org/10.1038/s41586-019-1485-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma S, Dubin AE, Zhang Y, Mousavi SAR, Wang Y, Coombs AM, Loud M, Andolfo I, Patapoutian A (2021) A role of PIEZO1 in iron metabolism in mice and humans. Cell. https://doi.org/10.1016/j.cell.2021.01.024

Article  PubMed  PubMed Central  Google Scholar 

Blythe NM, Muraki K, Ludlow MJ, Stylianidis V, Gilbert HTJ, Evans EL, Cuthbertson K, Foster R, Swift J, Li J, Drinkhill MJ, van Nieuwenhoven FA, Porter KE, Beech DJ, Turner NA (2019) Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion. J Biol Chem 294:17395–17408. https://doi.org/10.1074/jbc.RA119.009167

Article  CAS  PubMed  PubMed Central  Google Scholar 

Beech DJ, Kalli AC (2019) Force sensing by Piezo channels in cardiovascular health and disease. Arterioscler Thromb Vasc Biol 39:2228–2239. https://doi.org/10.1161/ATVBAHA.119.313348

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ranade SS, Qiu Z, Woo SH, Hur SS, Murthy SE, Cahalan SM, Xu J, Mathur J, Bandell M, Coste B, Li YS, Chien S, Patapoutian A (2014) Piezo1, a mechanically activated ion channel, is required for vascular development in mice. Proc Natl Acad Sci USA 111:10347–10352. https://doi.org/10.1073/pnas.1409233111

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li J, Hou B, Tumova S, Muraki K, Bruns A, Ludlow MJ, Sedo A, Hyman AJ, McKeown L, Young RS, Yuldasheva NY, Majeed Y, Wilson LA, Rode B, Bailey MA, Kim HR, Fu Z, Carter DA, Bilton J, Imrie H, Ajuh P, Dear TN, Cubbon RM, Kearney MT, Prasad RK, Evans PC, Ainscough JF, Beech DJ (2014) Piezo1 integration of vascular architecture with physiological force. Nature 515:279–282. https://doi.org/10.1038/nature13701

Article  CAS  PubMed  PubMed Central  Google Scholar 

Retailleau K, Duprat F, Arhatte M, Ranade SS, Peyronnet R, Martins JR, Jodar M, Moro C, Offermanns S, Feng Y, Demolombe S, Patel A, Honore E (2015) Piezo1 in smooth muscle cells is involved in hypertension-dependent arterial remodeling. Cell Rep 13:1161–1171. https://doi.org/10.1016/j.celrep.2015.09.072

Article  CAS  PubMed  Google Scholar 

Jin H, Li DY, Chernogubova E, Sun C, Busch A, Eken SM, Saliba-Gustafsson P, Winter H, Winski G, Raaz U, Schellinger IN, Simon N, Hegenloh R, Matic LP, Jagodic M, Ehrenborg E, Pelisek J, Eckstein HH, Hedin U, Backlund A, Maegdefessel L (2018) Local delivery of miR-21 stabilizes fibrous caps in vulnerable atherosclerotic lesions. Mol Ther 26:1040–1055. https://doi.org/10.1016/j.ymthe.2018.01.011

Article  CAS  PubMed  PubMed Central  Google Scholar 

Skogsberg J, Lundstrom J, Kovacs A, Nilsson R, Noori P, Maleki S, Kohler M, Hamsten A, Tegner J, Bjorkegren J (2008) Transcriptional profiling uncovers a network of cholesterol-responsive atherosclerosis target genes. PLoS Genet 4:e1000036. https://doi.org/10.1371/journal.pgen.1000036

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pelisek J, Hegenloh R, Bauer S, Metschl S, Pauli J, Glukha N, Busch A, Reutersberg B, Kallmayer M, Trenner M, Wendorff H, Tsantilas P, Schmid S, Knappich C, Schaeffer C, Stadlbauer T, Biro G, Wertern U, Meisner F, Stoklasa K, Menges AL, Radu O, Dallmann-Sieber S, Karlas A, Knipfer E, Reeps C, Zimmermann A, Maegdefessel L, Eckstein HH (2019) Biobanking: objectives, requirements, and future challenges-experiences from the munich vascular biobank. J Clin Med. https://doi.org/10.3390/jcm8020251

Article  PubMed  PubMed Central  Google Scholar 

Paloschi V, Pauli J, Winski G, Wu Z, Li Z, Botti L, Meucci S, Conti P, Rogowitz F, Glukha N, Hummel N, Busch A, Chernogubova E, Jin H, Sachs N, Eckstein HH, Dueck A, Boon RA, Bausch AR, Maegdefessel L (2023) Utilization of an artery-on-a-chip to unravel novel regulators and therapeutic targets in vascular diseases. Adv Healthc Mater.