Cyclase-associated protein (CAP) inhibits inverted formin 2 (INF2) to induce dendritic spine maturation

MU A, Fung TS, Francomacaro LM, Huynh T, Kotila T, Svindrych Z, Higgs HN (2020) Regulation of INF2-mediated actin polymerization through site-specific lysine acetylation of actin itself. Proc Natl Acad Sci USA 117:439–447

Article  PubMed  Google Scholar 

A MU, Fung TS, Kettenbach AN, Chakrabarti R, Higgs HN (2019) A complex containing lysine-acetylated actin inhibits the formin INF2. Nat Cell Biol 21:592–602

Article  PubMed  CAS  Google Scholar 

A MU, Latario CJ, Pickrell LE, Higgs HN (2020) Lysine acetylation of cytoskeletal proteins: Emergence of an actin code. J Cell Biol 219:e202006151

Article  PubMed  PubMed Central  Google Scholar 

Alimov N, Hoeprich GJ, Padrick SB, Goode BL (2023) Cyclase-associated protein interacts with actin filament barbed ends to promote depolymerization and formin displacement. J Biol Chem 299:105367

Article  PubMed  PubMed Central  CAS  Google Scholar 

Aspit L, Levitas A, Etzion S, Krymko H, Slanovic L, Zarivach R, Etzion Y, Parvari R (2019) CAP2 mutation leads to impaired actin dynamics and associates with supraventricular tachycardia and dilated cardiomyopathy. J Med Genet 56:228–235

Article  PubMed  CAS  Google Scholar 

Bosch M, Castro J, Saneyoshi T, Matsuno H, Sur M, Hayashi Y (2014) Structural and molecular remodeling of dendritic spine substructures during long-term potentiation. Neuron 82:444–459

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bosch M, Hayashi Y (2012) Structural plasticity of dendritic spines. Curr Opin Neurobiol 22:383–388

Article  PubMed  CAS  Google Scholar 

Boyer O, Nevo F, Plaisier E, Funalot B, Gribouval O, Benoit G, Huynh Cong E, Arrondel C, Tete MJ, Montjean R, Richard L, Karras A, Pouteil-Noble C, Balafrej L, Bonnardeaux A, Canaud G, Charasse C, Dantal J, Deschenes G, Deteix P, Dubourg O, Petiot P, Pouthier D, Leguern E, Guiochon-Mantel A, Broutin I, Gubler MC, Saunier S, Ronco P, Vallat JM, Alonso MA, Antignac C, Mollet G (2011) INF2 mutations in Charcot-Marie-Tooth disease with glomerulopathy. N Engl J Med 365:2377–2388

Article  PubMed  CAS  Google Scholar 

Breitsprecher D, Goode BL (2013) Formins at a glance. J Cell Sci 126:1–7

Article  PubMed  PubMed Central  CAS  Google Scholar 

Brown EJ, Schlondorff JS, Becker DJ, Tsukaguchi H, Tonna SJ, Uscinski AL, Higgs HN, Henderson JM, Pollak MR (2010) Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis. Nat Genet 42:72–76

Article  PubMed  CAS  Google Scholar 

Calabrese B, Jones SL, Shiraishi-Yamaguchi Y, Lingelbach M, Manor U, Svitkina TM, Higgs HN, Shih AY, Halpain S (2022) INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury. Nat Commun 13:6037

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cheema H, Bertoli-Avella AM, Skrahina V, Anjum MN, Waheed N, Saeed A, Beetz C, Perez-Lopez J, Rocha ME, Alawbathani S, Pereira C, Hovakimyan M, Patric IRP, Paknia O, Ameziane N, Cozma C, Bauer P, Rolfs A (2020) Genomic testing in 1019 individuals from 349 Pakistani families results in high diagnostic yield and clinical utility. NPJ Genom Med 5:44

Article  PubMed  PubMed Central  CAS  Google Scholar 

Colpan M, Iwanski J, Gregorio CC (2021) CAP2 is a regulator of actin pointed end dynamics and myofibrillogenesis in cardiac muscle. Commun Biol 4:365

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dominguez R (2020) Actin: Post-translational Modification of Actin Linked to Formin Inhibition. Curr Biol 29:R367–R370

Article  Google Scholar 

Drazic A, Aksnes H, Marie M, Boczkowska M, Varland S, Timmerman E, Foyn H, Glomnes N, Rebowski G, Impens F, Gevaert K, Dominguez R, Arnesen T (2018) NAA80 is actin’s N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility. Proc Natl Acad Sci USA 115:4399–4404

Article  PubMed  PubMed Central  CAS  Google Scholar 

Duffney LJ, Zhong P, Wei J, Matas E, Cheng J, Qin L, Ma K, Dietz DM, Kajiwara Y, Buxbaum JD, Yan Z (2015) Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators. Cell Rep 11:1400–1413

Article  PubMed  PubMed Central  CAS  Google Scholar 

Durand CM, Perroy J, Loll F, Perrais D, Fagni L, Bourgeron T, Montcouquiol M, Sans N (2012) SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism. Mol Psychiatry 17:71–84

Article  PubMed  CAS  Google Scholar 

Field J, Ye DZ, Shinde M, Liu F, Schillinger KJ, Lu M, Wang T, Skettini M, Xiong Y, Brice AK, Chung DC, Patel VV (2015) CAP2 in cardiac conduction, sudden cardiac death and eye development. Sci Rep 5:17256

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fromer M, Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S, Gormley P, Georgieva L, Rees E, Palta P, Ruderfer DM, Carrera N, Humphreys I, Johnson JS, Roussos P, Barker DD, Banks E, Milanova V, Grant SG, Hannon E, Rose SA, Chambert K, Mahajan M, Scolnick EM, Moran JL, Kirov G, Palotie A, McCarroll SA, Holmans P, Sklar P, Owen MJ, Purcell SM, O’Donovan MC (2014) De novo mutations in schizophrenia implicate synaptic networks. Nature 506:179–184

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gilman SR, Iossifov I, Levy D, Ronemus M, Wigler M, Vitkup D (2011) Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses. Neuron 70:898–907

Article  PubMed  PubMed Central  CAS  Google Scholar 

Görlich A, Zimmermann AM, Schober D, Bottcher RT, Sassoe-Pognetto M, Friauf E, Witke W, Rust MB (2012) Preserved morphology and physiology of excitatory synapses in profilin1-deficient mice. PLoS ONE 7:e30068

Article  PubMed  PubMed Central  Google Scholar 

Goodson M, Rust MB, Witke W, Bannerman D, Mott R, Ponting CP, Flint J (2012) Cofilin-1: a modulator of anxiety in mice. PLoS Genet 8:e1002970

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gu J, Lee CW, Fan Y, Komlos D, Tang X, Sun C, Yu K, Hartzell HC, Chen G, Bamburg JR, Zheng JQ (2010) ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity. Nat Neurosci 13:1208–1215

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gurunathan S, Sebastian J, Baker J, Abdel-Hamid HZ, West SC, Feingold B, Peche V, Reyes-Mugica M, Madan-Khetarpal S, Field J (2021) A homozygous CAP2 pathogenic variant in a neonate presenting with rapidly progressive cardiomyopathy and nemaline rods. Am J Med Genet A 188:970–977

Article  PubMed  Google Scholar 

Heinze A, Rust MB (2023) Loss of the actin regulator cyclase-associated protein 1 (CAP1) modestly affects dendritic spine remodeling during synaptic plasticity. Eur J Cell Biol 102:151357

Article  PubMed  CAS  Google Scholar 

Heinze A, Schuldt C, Khudayberdiev S, van Bommel B, Hacker D, Schulz TG, Stringhi R, Marcello E, Mikhaylova M, Rust MB (2022) Functional interdependence of the actin regulators CAP1 and cofilin1 in control of dendritic spine morphology. Cell Mol Life Sci 79:558

Article  PubMed  CAS  Google Scholar 

Hering H, Sheng M (2001) Dendritic spines: structure, dynamics and regulation. Nat Rev Neurosci 2:880–888

Article  PubMed  CAS  Google Scholar 

Hlushchenko I, Koskinen M, Hotulainen P (2016) Dendritic spine actin dynamics in neuronal maturation and synaptic plasticity. Cytoskeleton (Hoboken) 73:435–441

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