Akao T, Sakashita Y, Hanada M, Goto H, Shimada Y, Terasawa K (2004) Enteric excretion of baicalein, a flavone of Scutellariae radix, via glucuronidation in rat: Involvement of multidrug resistance-associated protein 2. Pharm Res 21:2120–2126. https://doi.org/10.1023/B:PHAM.0000048205.02478.b5

Article  CAS  PubMed  Google Scholar 

Aryal P, Kim K, Park PH, Ham S, Cho J, Song K (2014) Baicalein induces autophagic cell death through AMPK/ULK1 activation and downregulation of mTORC1 complex components in human cancer cells. FEBS J 281:4644–4658. https://doi.org/10.1111/febs.12969

Article  CAS  PubMed  Google Scholar 

Bandhavkar S (2016) Cancer stem cells: a metastasizing menace! Cancer Med 5:649–655. https://doi.org/10.1002/cam4.629

Article  PubMed  PubMed Central  Google Scholar 

Bie B, Sun J, Guo Y, Li J, Jiang W, Yang J, Huang C, Li Z (2017) Baicalein: A review of its anti-cancer effects and mechanisms in Hepatocellular Carcinoma. Biomed Pharmacother 93:1285–1291. https://doi.org/10.1016/j.biopha.2017.07.068

Article  CAS  PubMed  Google Scholar 

Bisht A, Zaman K, Singh M, Gupta R, Singh V (2011) Pharmacognostical studies on Oroxylum indicum (Linn.) Vent. stem bark. IJNPR 2:472–478

Google Scholar 

Chen L, Dou J, Su Z, Zhou H, Wang H, Zhou W, Guo Q, Zhou C (2011) Synergistic activity of baicalein with ribavirin against influenza A (H1N1) virus infections in cell culture and in mice. Antiviral Res 91:314–320. https://doi.org/10.1016/j.antiviral.2011.07.008

Article  CAS  PubMed  Google Scholar 

Chen J, Li Z, Chen AY, Ye X, Luo H, Rankin GO, Chen YC (2013) Inhibitory effect of baicalin and baicalein on ovarian cancer cells. Int J Mol Sci 14:6012–6025. https://doi.org/10.3390/ijms14036012

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen F, Zhuang M, Peng J, Wang X, Huang T, Li S, Lin M, Lin H, Xu Y, Li J, Chen Z, Huang Y (2014) Baicalein inhibits migration and invasion of gastric cancer cells through suppression of the TGF-β signaling pathway. Mol Med Rep 10:1999–2003. https://doi.org/10.3892/mmr.2014.2452

Article  CAS  PubMed  Google Scholar 

Chen Y, Liu T, Wang K, Hou C, Cai S, Huang Y, Du Z, Huang H, Kong J, Chen Y (2016) Baicalein inhibits Staphylococcus aureus biofilm formation and the quorum sensing system in vitro. PLoS ONE 11:e0153468. https://doi.org/10.1371/journal.pone.0153468

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen ME, Su CH, Yang JS, Lu CC, Hou YC, Wu JB, Hsu YM (2018) Baicalin, baicalein, and Lactobacillus rhamnosus JB3 alleviated Helicobacter pylori infections in vitro and in vivo. J Food Sci 83:3118–3125. https://doi.org/10.1111/1750-3841.14372

Article  CAS  PubMed  Google Scholar 

Chen M, Peng L, Gong P, Zheng X, Sun T, Zhang X, Huo J (2022) Baicalein induces mitochondrial autophagy to prevent Parkinson’s disease in rats via miR-30b and the SIRT1/AMPK/mTOR pathway. Front Neurol 12:2548. https://doi.org/10.3389/FNEUR.2021.646817/BIBTEX

Article  Google Scholar 

Chmiel M, Stompor M (2023) Promising role of the Scutellaria baicalensis root hydroxyflavone–baicalein in the prevention and treatment of human diseases. Int J Mol Sci 24:4732. https://doi.org/10.3390/ijms24054732

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dai C, Tang S, Wang Y, Velkov T, Xiao X (2017) Baicalein acts as a nephroprotectant that ameliorates colistin-induced nephrotoxicity by activating the antioxidant defence mechanism of the kidneys and down-regulating the inflammatory response. J Antimicrob Chemother 72:2562–2569. https://doi.org/10.1093/jac/dkx185

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dinda B, Dinda S, DasSharma S, Banik R, Chakraborty A, Dinda M (2017) Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders. Eur J Med Chem 131:68–80. https://doi.org/10.1016/j.ejmech.2017.03.004

Article  CAS  PubMed  Google Scholar 

Dong R, Li L, Gao H, Lou K, Luo H, Hao S, Yuan J, Liu Z (2021) Safety, tolerability, pharmacokinetics, and food effect of baicalein tablets in healthy Chinese subjects: a single-center, randomized, double-blind, placebo-controlled, single-dose phase I study. J Ethnopharmacol 274:114052. https://doi.org/10.1016/j.jep.2021.114052

Article  CAS  PubMed  Google Scholar 

Dunkhunthod B, Talabnin C, Murphy M, Thumanu K, Sittisart P, Hengpratom T, Eumkeb G (2020) Intracellular ROS scavenging and anti-inflammatory activities of Oroxylum indicum Kurz (L.) extract in LPS plus IFN-γ-activated RAW264.7 macrophages. Evid Based ComplementAlternat Med 2020:7436920. https://doi.org/10.1155/2020/7436920

Article  Google Scholar 

El-Ela SRA, Zaghloul RA, Eissa LA (2022) Promising cardioprotective effect of baicalin in doxorubicin-induced cardiotoxicity through targeting toll-like receptor 4/nuclear factor-κB and Wnt/β-catenin pathways. Nutr 102:111732. https://doi.org/10.1016/j.nut.2022.111732

Article  CAS  Google Scholar 

Fan GW, Zhang Y, Jiang X, Zhu Y, Wang B, Su L, Cao W, Zhang H, Gao X (2013) Anti-inflammatory activity of baicalein in LPS-stimulated RAW264.7 macrophages via estrogen receptor and NF-κB-dependent pathways. Inflammation 36:1584–1591. https://doi.org/10.1007/s10753-013-9703-2

Article  CAS  PubMed  Google Scholar 

Gandhi NM (2013) Baicalein protects mice against radiation-induced DNA damages and genotoxicity. Mol Cell Bioche 379:277–281. https://doi.org/10.1007/s11010-013-1649-z

Article  CAS  Google Scholar 

Gao J, Morgan WA, Sanchez-Medina A, Corcora O (2011) The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. Toxicol Appl Pharmacol 254:221–228. https://doi.org/10.1016/j.taap.2011.03.016

Article  CAS  PubMed  Google Scholar 

Gao Y, Snyder SA, Smith JN, Chen YC (2016) Anticancer properties of baicalein: a review. Med Chem Res 25:1515–1523. https://doi.org/10.1007/s00044-016-1607-xGastric

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gu Y, Zheng Q, Fan G, Liu R (2022) Advances in anti-cancer activities of flavonoids in Scutellariae radix: perspectives on mechanism. Int J Mol Sci 23:11042. https://doi.org/10.3390/IJMS231911042

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo Z, Hu X, Xing Z, Xing R, Lv R, Cheng X, Su J, Zhou Z, Xu Z, Nilsson S, Liu Z (2015) Baicalein inhibits prostate cancer cell growth and metastasis via the caveolin-1/AKT/mTOR pathway. Mol Cell Biochem 406:111–119. https://doi.org/10.1007/s11010-015-2429-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haider M, Hassan M, Ahmed I, Shamma R (2018) Thermogelling platform for baicalin delivery for versatile biomedical applications. Mol Pharm 15:3478–3488. https://doi.org/10.1021/acs.molpharmaceut.8b00480

Article  CAS  PubMed  Google Scholar 

Han Z, Zhu S, Han X, Wang Z, Wu S, Zheng R (2015) Baicalein inhibits hepatocellular carcinoma cells through suppressing the expression of CD24. Int Immunopharmacol 29:416–422. https://doi.org/10.1016/j.intimp.2015.10.021

Article  CAS  PubMed  Google Scholar 

He X, Li Z, Rizak JD, Wu S, Wang Z, He R, Su M, Qin D, Wang J, Hu X (2017) Resveratrol attenuates formaldehyde induced hyperphosphorylation of tau protein and cytotoxicity in N2a cells. Front Neurosci 10:598. https://doi.org/10.3389/FNINS.2016.00598/BIBTEX

Article  PubMed  PubMed Central  Google Scholar 

Huang WS, Kuo YH, Chin CC, Wang JY, Yu HR, Sheen JM, Tung SY, Shen CH, Chen TC, Sung ML, Liang HF, Kuo HC (2012) Proteomic analysis of the effects of baicalein on colorectal cancer cells. Proteomics 12:810–819. https://doi.org/10.1002/pmic.201100270

Article  CAS  PubMed