Agus A, Planchais J, Sokol H. Gut microbiota regulation of Tryptophan Metabolism in Health and Disease. Cell Host Microbe. 2018;23(6):716–24.

Article  CAS  PubMed  Google Scholar 

Peterson LW, Artis D. Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat Rev Immunol. 2014;14(3):141–53.

Article  CAS  PubMed  Google Scholar 

Shao R, Yang Y, Zhang Y, et al. The expression of thioredoxin-1 and inflammatory cytokines in patients with sepsis. Immunopharmacol Immunotoxicol. 2020;42(3):280–5.

Article  CAS  PubMed  Google Scholar 

Giamarellos-Bourboulis EJ, Aschenbrenner AC, Bauer M, et al. The pathophysiology of sepsis and precision-medicine-based immunotherapy. Nat Immunol. 2024;25(1):19–28.

Article  CAS  PubMed  Google Scholar 

Zheng M, Han R, Yuan Y, et al. The role of Akkermansia muciniphila in inflammatory bowel disease: current knowledge and perspectives. Front Immunol. 2022;13:1089600.

Article  CAS  PubMed  Google Scholar 

Rooks MG, Garrett WS. Gut microbiota, metabolites and host immunity. Nat Rev Immunol. 2016;16(6):341–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sittipo P, Lobionda S, Lee YK, et al. Intestinal microbiota and the immune system in metabolic diseases. J Microbiol. 2018;56(3):154–62.

Article  CAS  PubMed  Google Scholar 

Belkaid Y, Harrison OJ. Homeostatic immunity and the Microbiota. Immunity. 2017;46(4):562–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cani PD. Human gut microbiome: hopes, threats and promises. Gut. 2018;67(9):1716–25.

Article  CAS  PubMed  Google Scholar 

Cani PD, Amar J, Iglesias MA, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56(7):1761–72.

Article  CAS  PubMed  Google Scholar 

McKenzie C, Tan J, Macia L, et al. The nutrition-gut microbiome-physiology axis and allergic diseases. Immunol Rev. 2017;278(1):277–95.

Article  CAS  PubMed  Google Scholar 

Postler TS, Ghosh S. Understanding the Holobiont: how microbial metabolites affect human health and shape the Immune System. Cell Metab. 2017;26(1):110–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Derrien M, Belzer C, de Vos WM. Akkermansia muciniphila and its role in regulating host functions. Microb Pathog. 2017;106:171–81.

Article  PubMed  Google Scholar 

Derrien M, Vaughan EE, Plugge CM, et al. Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium. Int J Syst Evol Microbiol. 2004;54(Pt 5):1469–76.

Article  CAS  PubMed  Google Scholar 

Ouwerkerk JP, Aalvink S, Belzer C, et al. Akkermansia glycaniphila sp. nov., an anaerobic mucin-degrading bacterium isolated from reticulated python faeces. Int J Syst Evol Microbiol. 2016;66(11):4614–20.

Article  CAS  PubMed  Google Scholar 

Kobayashi Y, Kawahara T, Inoue S et al. Akkermansia biwaensis sp. nov., an anaerobic mucin-degrading bacterium isolated from human faeces. Int J Syst Evol Microbiol, 2023. 73(1).

Gilroy R, Ravi A, Getino M, et al. Extensive microbial diversity within the chicken gut microbiome revealed by metagenomics and culture. PeerJ. 2021;9:e10941.

Article  PubMed  PubMed Central  Google Scholar 

Ndongo S, Armstrong N, Raoult D, et al. Reclassification of eight Akkermansia muciniphila strains and description of Akkermansia massiliensis sp. nov. and Candidatus Akkermansia timonensis, isolated from human feces. Sci Rep. 2022;12(1):21747.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kumar R, Hasselwander O, Kane H et al. Akkermansia beyond muciniphila - emergence of new species Akkermansia massiliensis sp. nov. Microbiome Res Rep, 2024. 3(3).

Ottman N, Huuskonen L, Reunanen J, et al. Characterization of outer membrane proteome of Akkermansia muciniphila reveals sets of Novel proteins exposed to the human intestine. Front Microbiol. 2016;7:1157.

Article  PubMed  PubMed Central  Google Scholar 

Derrien M, Van Baarlen P, Hooiveld G, et al. Modulation of Mucosal Immune Response, Tolerance, and proliferation in mice colonized by the mucin-degrader Akkermansia muciniphila. Front Microbiol. 2011;2:166.

Article  PubMed  PubMed Central  Google Scholar 

Reunanen J, Kainulainen V, Huuskonen L, et al. Akkermansia muciniphila adheres to enterocytes and strengthens the Integrity of the epithelial cell layer. Appl Environ Microbiol. 2015;81(11):3655–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Depommier C, Van Hul M, Everard A, et al. Pasteurized Akkermansia muciniphila increases whole-body energy expenditure and fecal energy excretion in diet-induced obese mice. Gut Microbes. 2020;11(5):1231–45.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang L, Tang L, Feng Y, et al. A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8(+) T cells in mice. Gut. 2020;69(11):1988–97.

Article  CAS  PubMed  Google Scholar 

Everard A, Belzer C, Geurts L, et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci U S A. 2013;110(22):9066–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao S, Liu W, Wang J, et al. Akkermansia muciniphila improves metabolic profiles by reducing inflammation in chow diet-fed mice. J Mol Endocrinol. 2017;58(1):1–14.

Article  PubMed  Google Scholar 

Si J, Kang H, You HJ, et al. Revisiting the role of Akkermansia muciniphila as a therapeutic bacterium. Gut Microbes. 2022;14(1):2078619.

Article  PubMed  PubMed Central  Google Scholar 

Shin NR, Lee JC, Lee HY, et al. An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice. Gut. 2014;63(5):727–35.

Article  CAS  PubMed  Google Scholar 

Li J, Lin S, Vanhoutte PM, et al. Akkermansia Muciniphila protects against atherosclerosis by preventing Metabolic Endotoxemia-Induced inflammation in Apoe-/- mice. Circulation. 2016;133(24):2434–46.

Article  CAS  PubMed  Google Scholar 

Plovier H, Everard A, Druart C, et al. A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice. Nat Med. 2017;23(1):107–13.

Article  CAS  PubMed  Google Scholar 

Qian K, Chen S, Wang J, et al. A β-N-acetylhexosaminidase Amuc_2109 from Akkermansia muciniphila protects against dextran sulfate sodium-induced colitis in mice by enhancing intestinal barrier and modulating gut microbiota. Food Funct. 2022;13(4):2216–27.

Article  CAS  PubMed  Google Scholar 

Jiang Y, Xu Y, Zheng C, et al. Acetyltransferase from Akkermansia muciniphila blunts colorectal tumourigenesis by reprogramming tumour microenvironment. Gut. 2023;72(7):1308–18.

Article  CAS