The role of ribosomal DNA methylation in embryonic development, aging and diseases

Gonzalez IL, Sylvester JE. Complete sequence of the 43-kb human ribosomal DNA repeat: analysis of the intergenic spacer. Genomics. 1995;27(2):320–8.

Article  CAS  PubMed  Google Scholar 

Little RD, Braaten DC. Genomic organization of human 5S rDNA and sequence of one tandem repeat. Genomics. 1989;4(3):376–83.

Article  CAS  PubMed  Google Scholar 

Sorensen PD, Frederiksen S. Characterization of human 5S rRNA genes. Nucleic Acids Res. 1991;19(15):4147–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cerqueira AV, Lemos B. Ribosomal DNA and the nucleolus as keystones of nuclear architecture, organization, and function. Trends Genet. 2019;35(10):710–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smirnov E, Chmurciakova N, Cmarko D. Hum rDNA cancer Cells, 2021. 10(12).

Kopp K, et al. Pol I transcription and pre-rRNA processing are coordinated in a transcription-dependent manner in mammalian cells. Mol Biol Cell. 2007;18(2):394–403.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Henderson AS, Warburton D, Atwood KC. Location of ribosomal DNA in the human chromosome complement. Proc Natl Acad Sci U S A. 1972;69(11):3394–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Steffensen DM, Duffey P, Prensky W. Localisation of 5S ribosomal RNA genes on human chromosome 1. Nature. 1974;252(5485):741–3.

Article  CAS  PubMed  Google Scholar 

Croce CM, et al. Suppression of production of mouse 28S ribosomal RNA in mouse-human hybrids segregating mouse chromosomes. Proc Natl Acad Sci U S A. 1977;74(2):694–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grozdanov P, Georgiev O, Karagyozov L. Complete sequence of the 45-kb mouse ribosomal DNA repeat: analysis of the intergenic spacer. Genomics. 2003;82(6):637–43.

Article  CAS  PubMed  Google Scholar 

Matsuda Y, et al. Chromosomal mapping of mouse 5S rRNA genes by direct R-banding fluorescence in situ hybridization. Cytogenet Cell Genet. 1994;66(4):246–9.

Article  CAS  PubMed  Google Scholar 

Chebrout M et al. Transcription of rRNA in early mouse embryos promotes chromatin reorganization and expression of major satellite repeats. J Cell Sci, 2022. 135(6).

Kang J, et al. Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy. Signal Transduct Target Ther. 2021;6(1):323.

Article  CAS  PubMed  PubMed Central  Google Scholar 

D’Aquila P, et al. Methylation of the ribosomal RNA gene promoter is associated with aging and age-related decline. Aging Cell. 2017;16(5):966–75.

Article  PubMed  PubMed Central  Google Scholar 

Srivastava R, Srivastava R, Ahn SH. The epigenetic pathways to ribosomal DNA silencing. Microbiol Mol Biol Rev. 2016;80(3):545–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McStay B, Grummt I. The epigenetics of rRNA genes: from molecular to chromosome biology. Annu Rev Cell Dev Biol. 2008;24:131–57.

Article  CAS  PubMed  Google Scholar 

Santoro R, Grummt I. Molecular mechanisms mediating methylation-dependent silencing of ribosomal gene transcription. Mol Cell. 2001;8(3):719–25.

Article  CAS  PubMed  Google Scholar 

Bestor TH. DNA methylation - evolution of a bacterial immune function into a regulator of gene-expression and genome structure in higher eukaryotes. Philosophical Trans Royal Soc Lond Ser B-Biological Sci. 1990;326(1235):179–87.

CAS  Google Scholar 

Moore LD, Le T, Fan GP. DNA Methylation its Basic Function Neuropsychopharmacol. 2013;38(1):23–38.

CAS  Google Scholar 

Xiong Z, et al. EWAS Open platform: integrated data, knowledge and toolkit for epigenome-wide association study. Nucleic Acids Res. 2022;50(D1):D1004–9.

Article  CAS  PubMed  Google Scholar 

Zhang MC, et al. MethBank 4.0: an updated database of DNA methylation across a variety of species. Nucleic Acids Res. 2023;51(D1):D208–16.

Article  CAS  PubMed  Google Scholar 

Zong W, et al. scMethBank: a database for single-cell whole genome DNA methylation maps. Nucleic Acids Res. 2022;50(D1):D380–6.

Article  CAS  PubMed  Google Scholar 

Wang M, Lemos B. Ribosomal DNA harbors an evolutionarily conserved clock of biological aging. Genome Res. 2019;29(3):325–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Furuta A, Nakamura T. DNA hypomethylation circuit of mouse rDNA repeats in the germ cell lineage. Biochem Biophys Res Commun. 2017;490(2):429–33.

Article  CAS  PubMed  Google Scholar 

Shao FQ et al. Methylation of 45S ribosomal DNA (rDNA) is associated with cancer and aging in humans International Journal of Genomics, 2021. 2021.

Potabattula R, et al. Increasing methylation of sperm rDNA and other repetitive elements in the aging male mammalian germline. Aging Cell. 2020;19(8):e13181.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oakes CC, et al. Aging results in hypermethylation of ribosomal DNA in sperm and liver of male rats. Proc Natl Acad Sci USA. 2003;100(4):1775–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Potabattula R, et al. Ribosomal DNA methylation in human and mouse oocytes increases with age. Aging. 2022;14(3):1214–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ortega-Recalde O, et al. Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation. Nat Commun. 2019;10(1):3053.

Article  PubMed  PubMed Central  Google Scholar 

Watada E et al. Age-dependent ribosomal DNA variations in mice. Mol Cell Biol, 2020. 40(22).

Flunkert J, et al. Genetic and epigenetic changes in clonal descendants of irradiated human fibroblasts. Exp Cell Res. 2018;370(2):322–32.

Article  CAS  PubMed  Google Scholar 

Murach KA et al. Late-life exercise mitigates skeletal muscle epigenetic aging. Aging Cell, 2022. 21(1).

Gensous N et al. Aging and caloric restriction modulate the DNA methylation profile of the ribosomal RNA locus in human and rat liver. Nutrients, 2020. 12(2).

Pietrzak M, et al. Epigenetic silencing of nucleolar rRNA genes in Alzheimer’s disease. PLoS ONE. 2011;6(7):e22585.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Razzaq A et al. Ribosomal DNA copy number variation is coupled with DNA methylation changes at the 45S rdna locus. Epigenetics, 2023. 18(1).

Raval A, et al. Reduced rRNA expression and increased rDNA promoter methylation in CD34 + cells of patients with myelodysplastic syndromes. Blood. 2012;120(24):4812–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

留言 (0)

沒有登入
gif