Newell LF, Cook RJ. Advances in acute myeloid leukemia. BMJ. 2021. https://doi.org/10.1136/bmj.n2026.

Article  PubMed  Google Scholar 

Rowe JM. Changing trends in the therapy of acute myeloid leukemia. Best Pract Res Clin Haematol. 2021;34: 101333.

Article  CAS  PubMed  Google Scholar 

Wang H, Sica RA, Kaur G, Galbo PM, Jing Z, Nishimura CD, et al. TMIGD2 is an orchestrator and therapeutic target on human acute myeloid leukemia stem cells. Nat Commun. 2024;15:11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stelmach P, Trumpp A. Leukemic stem cells and therapy resistance in acute myeloid leukemia. Haematologica. 2023;108:353–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bouligny IM, Murray G, Doyel M, Patel T, Boron J, Tran V, et al. Venetoclax with decitabine or azacitidine in relapsed or refractory acute myeloid leukemia. Med Oncol. 2024;41:80.

Article  CAS  PubMed  Google Scholar 

Thol F, Ganser A. Treatment of relapsed acute myeloid leukemia. Curr Treat Options Oncol. 2020;21:66.

Article  PubMed  PubMed Central  Google Scholar 

Bercier P, de Thé H. History of developing acute promyelocytic leukemia treatment and role of promyelocytic leukemia bodies. Cancers. 2024;16:1351.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weeda V, Mestrum SGC, Leers MPG. Flow cytometric identification of hematopoietic and leukemic blast cells for tailored clinical follow-up of acute myeloid leukemia. Int J Mol Sci. 2022;23:10529.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Plesa A, Dumontet C, Mattei E, Tagoug I, Hayette S, Sujobert P, et al. High frequency of CD34+CD38−/low immature leukemia cells is correlated with unfavorable prognosis in acute myeloid leukemia. World J Stem Cells. 2017;9:227–34.

Article  PubMed  PubMed Central  Google Scholar 

Goardon N, Marchi E, Atzberger A, Quek L, Schuh A, Soneji S, et al. Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia. Cancer Cell. 2011;19:138–52.

Article  CAS  PubMed  Google Scholar 

Kamel AM, Elsharkawy NM, Kandeel EZ, Hanafi M, Samra M, Osman RA. Leukemia stem cell frequency at diagnosis correlates with measurable/minimal residual disease and impacts survival in adult acute myeloid leukemia. Front Oncol. 2022;12: 867684.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vergez F, Nicolau-Travers M-L, Bertoli S, Rieu J-B, Tavitian S, Bories P, et al. CD34+CD38−CD123+ leukemic stem cell frequency predicts outcome in older acute myeloid leukemia patients treated by intensive chemotherapy but not hypomethylating agents. Cancers. 2020;12:1174.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singh P, Lim B. Targeting apoptosis in cancer. Curr Oncol Rep. 2022;24:273–84.

Article  CAS  PubMed  Google Scholar 

Carneiro BA, El-Deiry WS. Targeting apoptosis in cancer therapy. Nat Rev Clin Oncol. 2020;17:395–417.

Article  PubMed  PubMed Central  Google Scholar 

Wani AK, Akhtar N, Mir TUG, Singh R, Jha PK, Mallik SK, et al. Targeting apoptotic pathway of cancer cells with phytochemicals and plant-based nanomaterials. Biomolecules. 2023;13:194.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maher T, Ahmad Raus R, Daddiouaissa D, Ahmad F, Adzhar NS, Latif ES, et al. Medicinal plants with anti-leukemic effects: a review. Molecules. 2021;26:2741.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Limam I, Ben Aissa-Fennira F, Essid R, Chahbi A, Kefi S, Mkadmini K, et al. Hydromethanolic root and aerial part extracts from Echium arenarium Guss suppress proliferation and induce apoptosis of multiple myeloma cells through mitochondrial pathway. Environ Toxicol. 2021;36:874–86.

Article  CAS  PubMed  Google Scholar 

Limam I, Abdelkarim M, Essid R, Chahbi A, Fathallah M, Elkahoui S, et al. Olea europaea L. cv. Chetoui leaf and stem hydromethanolic extracts suppress proliferation and promote apoptosis via caspase signaling on human multiple myeloma cells. Eur J Integr Med. 2020;37:101145.

Article  Google Scholar 

Hendel N, Djamel S, Madani S, Selloum M, Boussakra F, Driche O. Screening for in vitro antioxidant activity and antifungal effect of Artemisia campestris. Int J Agric Environ Food Sci. 2021;5:251–9.

Google Scholar 

Dib I, El Alaoui-Faris FE. Artemisia campestris L.: review on taxonomical aspects, cytogeography, biological activities and bioactive compounds. Biomed Pharmacother. 2019;109:1884–906.

Article  PubMed  Google Scholar 

Lee SH, Lee M-Y, Kang H-M, Han DC, Son K-H, Yang DC, et al. Anti-tumor activity of the farnesyl-protein transferase inhibitors arteminolides, isolated from Artemisa. Bioorg Med Chem. 2003;11:4545–9.

Article  CAS  PubMed  Google Scholar 

Dib I, Angenot L, Mihamou A, Ziyyat A, Tits M. Artemisia campestris L.: ethnomedicinal, phytochemical and pharmacological review. J Herb Med. 2017;7:1–10.

Article  Google Scholar 

Jabri M-A, Tounsi H, Abdellaoui A, Marzouki L, Sebai H. Protective effects of Artemisia campestris extract against gastric acid reflux-induced esophageal mucosa injuries. Pathophysiol Off J Int Soc Pathophysiol. 2018;25:63–9.

CAS  Google Scholar 

Akrout A, Gonzalez LA, El Jani H, Madrid PC. Antioxidant and antitumor activities of Artemisia campestris and Thymelaea hirsuta from southern Tunisia. Food Chem Toxicol Int J Publ Br Ind Biol Res Assoc. 2011;49:342–7.

Article  CAS  Google Scholar 

Metoui R, Mighri H, Bouajila J, Znati M, El-Jani H, Akrout A. Artemisia campestris dried leaf extracts: effects of different extraction methods and solvents on phenolic composition and biological activities. South Afr J Bot. 2022;151:288–94.

Article  CAS  Google Scholar 

Limam I, Ghali R, Abdelkarim M, Ouni A, Araoud M, Abdelkarim M, et al. Tunisian Artemisia campestris L.: a potential therapeutic agent against myeloma—phytochemical and pharmacological insights. Plant Methods. 2024;20:59.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feng X, Cao S, Qiu F, Zhang B. Traditional application and modern pharmacological research of Artemisia annua L. Pharmacol Ther. 2020;216: 107650.

Article  CAS  PubMed  Google Scholar 

Jaouadi O, Limam I, Abdelkarim M, Berred E, Chahbi A, Caillot M, et al. 5,6-Epoxycholesterol isomers induce oxiapoptophagy in myeloma cells. Cancers. 2021;13:3747.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Salehi A. A novel therapeutic strategy: the significance of exosomal miRNAs in acute myeloid leukemia. Med Oncol. 2024;41:62.

Article  CAS  PubMed  Google Scholar 

Macanas-Pirard P, Broekhuizen R, González A, Oyanadel C, Ernst D, García P, et al. Resistance of leukemia cells to cytarabine chemotherapy is mediated by bone marrow stroma, involves cell-surface equilibrative nucleoside transporter-1 removal and correlates with patient outcome. Oncotarget. 2017;8:23073–86.

Article  PubMed  PubMed Central  Google Scholar 

Mancuso RI, Foglio MA, Olalla Saad ST. Artemisinin-type drugs for the treatment of hematological malignancies. Cancer Chemother Pharmacol. 2021;87:1–22.

Article  CAS