Miller KD, Fidler-Benaoudia M, Keegan TH, Hipp HS, Jemal A, et al. Cancer statistics for adolescents and young adults, 2020. CA Cancer J Clin. 2020;70:443–59.

Article  PubMed  Google Scholar 

González-Martín A, Harter P, Leary A, Lorusso D, Miller RE, et al. Newly diagnosed and relapsed epithelial ovarian cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann Oncol. 2023;34:833–48.

Article  PubMed  Google Scholar 

Reid BM, Permuth JB, Sellers TA. Epidemiology of ovarian cancer: a review. Cancer Biol Med. 2017;14:9–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ozga M, Aghajanian C, Myers-Virtue S, McDonnell G, Jhanwar S, et al. A systematic review of ovarian cancer and fear of recurrence. Palliat Support Care. 2015;13:1771–80.

Article  PubMed  PubMed Central  Google Scholar 

Felder M, Kapur A, Gonzalez-Bosquet J, Horibata S, Heintz J, et al. MUC16 (CA125): tumor biomarker to cancer therapy, a work in progress. Mol Cancer. 2014;13:129.

Article  PubMed  PubMed Central  Google Scholar 

Lakshmanan M, Kumar V, Chaturvedi A, Misra S, Gupta S, et al. Role of serum HE4 as a prognostic marker in carcinoma of the ovary. Indian J Cancer. 2019;56:216–21.

Article  PubMed  Google Scholar 

Ding Q, Dong S, Wang R, Zhang K, Wang H, et al. A nine-gene signature related to tumor microenvironment predicts overall survival with ovarian cancer. Aging. 2020;12:4879–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao J, Yan Q. Cancer Epigenetics, Tumor Immunity, and Immunotherapy. Trends Cancer. 2020;6:580–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hai R, He L, Shu G, Yin G. Characterization of Histone Deacetylase Mechanisms in Cancer Development. Front Oncol. 2021;11: 700947.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shen Y, Wei W, Zhou DX. Histone Acetylation Enzymes Coordinate Metabolism and Gene Expression. Trends Plant Sci. 2015;20:614–21.

Article  CAS  PubMed  Google Scholar 

Mi W, Guan H, Lyu J, Zhao D, Xi Y, et al. YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer. Nat Commun. 2017;8:1088.

Article  PubMed  PubMed Central  Google Scholar 

Rajan PK, Udoh UA, Sanabria JD, Banerjee M, Smith G, et al. The Role of Histone Acetylation-/Methylation-Mediated Apoptotic Gene Regulation in Hepatocellular Carcinoma. Int J Mol Sci. 2020;21:8894.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang R, Langdon SP, Tse M, Mullen P, Um IH, et al. The role of HDAC2 in chromatin remodelling and response to chemotherapy in ovarian cancer. Oncotarget. 2016;7:4695–711.

Article  PubMed  Google Scholar 

Xie W, Sun H, Li X, Lin F, Wang Z, et al. Ovarian cancer: epigenetics, drug resistance, and progression. Cancer Cell Int. 2021;21:434.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Muscolini M, Cianfrocca R, Sajeva A, Mozzetti S, Ferrandina G, et al. Trichostatin A up-regulates p73 and induces Bax-dependent apoptosis in cisplatin-resistant ovarian cancer cells. Mol Cancer Ther. 2008;7:1410–9.

Article  CAS  PubMed  Google Scholar 

Dizon DS, Blessing JA, Penson RT, Drake RD, Walker JL, et al. A phase II evaluation of belinostat and carboplatin in the treatment of recurrent or persistent platinum-resistant ovarian, fallopian tube, or primary peritoneal carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2012;125:367–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marsh DJ, Shah JS, Cole AJ. Histones and their modifications in ovarian cancer - drivers of disease and therapeutic targets. Front Oncol. 2014;4:144.

Article  PubMed  PubMed Central  Google Scholar 

Odunsi K. Immunotherapy in ovarian cancer. Ann Oncol. 2017;28:viii1–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012;366:2455–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Topper MJ, Vaz M, Marrone KA, Brahmer JR, Baylin SB. The emerging role of epigenetic therapeutics in immuno-oncology. Nat Rev Clin Oncol. 2020;17:75–90.

Article  PubMed  Google Scholar 

Gil J, Ramírez-Torres A, Encarnación-Guevara S. Lysine acetylation and cancer: A proteomics perspective. J Proteomics. 2017;150:297–309.

Article  CAS  PubMed  Google Scholar 

Rosenberg JE, Hoffman-Censits J, Powles T, van der Heijden MS, Balar AV, et al. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Lancet. 2016;387:1909–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mariathasan S, Turley SJ, Nickles D, Castiglioni A, Yuen K, et al. TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells. Nature. 2018;554:544–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma B, Wang K, Liang Y, Meng Q, Li Y. Molecular Characteristics, Oncogenic Roles, and Relevant Immune and Pharmacogenomic Features of EVA1B in Colorectal Cancer. Front Immunol. 2022;13:809837.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qiu C, Shi W, Wu H, Zou S, Li J, et al. Identification of Molecular Subtypes and a Prognostic Signature Based on Inflammation-Related Genes in Colon Adenocarcinoma. Front Immunol. 2021;12:769685.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zeng D, Ye Z, Shen R, Yu G, Wu J, et al. IOBR: Multi-Omics Immuno-Oncology Biological Research to Decode Tumor Microenvironment and Signatures. Front Immunol. 2021;12:687975.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Malta TM, Sokolov A, Gentles AJ, Burzykowski T, Poisson L, et al. Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation. Cell. 2018;173:338–54.e15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Wang J, Li L, Qin H, Wei Y, et al. AC010973.2 promotes cell proliferation and is one of six stemness-related genes that predict overall survival of renal clear cell carcinoma. Sci Rep. 2022;12:4272.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fu J, Li K, Zhang W, Wan C, Zhang J, et al. Large-scale public data reuse to model immunotherapy response and resistance. Genome Med. 2020;12:21.

Article  PubMed  PubMed Ce