Integrated systematic functional screen and fine-mapping decipher the role and genetic regulation of RPS19 in colorectal cancer development

Angelini M, Cannata S, Mercaldo V et al (2007) Missense mutations associated with Diamond–Blackfan anemia affect the assembly of ribosomal protein S19 into the ribosome. Hum Mol Genet 16(14):1720–1727. https://doi.org/10.1093/hmg/ddm120

Article  CAS  PubMed  Google Scholar 

Ardlie KG, Deluca DS, Segrè AV, Sullivan TJ, Young TR, Dermitzakis ET (2015) The genotype-tissue expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science 348(6235):648–60. https://doi.org/10.1126/science.1262110

Article  CAS  Google Scholar 

Bibikova E, Youn MY, Danilova N et al (2014) TNF-mediated inflammation represses GATA1 and activates p38 MAP kinase in RPS19-deficient hematopoietic progenitors. Blood 124(25):3791–3798. https://doi.org/10.1182/blood-2014-06-584656

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao Z, Cheng Y, Wang J et al (2021) HBP1-mediated transcriptional repression of AFP inhibits hepatoma progression. J Exp Clinical Cancer Res CR 40(1):118. https://doi.org/10.1186/s13046-021-01881-2

Article  CAS  PubMed  Google Scholar 

Chang J, Tian J, Yang Y et al (2018) A rare missense variant in TCF7L2 associates with colorectal cancer risk by interacting with a GWAS-identified regulatory variant in the MYC enhancer. Can Res 78(17):5164–5172. https://doi.org/10.1158/0008-5472.Can-18-0910

Article  CAS  Google Scholar 

Chen W, Zheng R, Baade PD et al (2015) Cancer statistics in China. CA Cancer J Clin 66(2):115–32. https://doi.org/10.3322/caac.21338

Article  CAS  Google Scholar 

Chen Z, Guo X, Tao R et al (2024) Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes. Nat Commun 15(1):3557. https://doi.org/10.1038/s41467-024-47399-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Claeys S, Denecker G, Durinck K et al (2019) ALK positively regulates MYCN activity through repression of HBP1 expression. Oncogene 38(15):2690–2705. https://doi.org/10.1038/s41388-018-0595-3

Article  CAS  PubMed  Google Scholar 

Das S, Forer L, Schönherr S et al (2016) Next-generation genotype imputation service and methods. Nat Genet 48(10):1284–1287. https://doi.org/10.1038/ng.3656

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Chiara C, Giannini C, Adinolfi S et al (2003) The AXH module: an independently folded domain common to ataxin-1 and HBP1. FEBS Lett 551(1–3):107–112. https://doi.org/10.1016/s0014-5793(03)00818-4

Article  PubMed  Google Scholar 

Fernandez-Rozadilla C, Timofeeva M, Chen Z et al (2023) Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries. Nat Genet 55(1):89–99. https://doi.org/10.1038/s41588-022-01222-9

Article  CAS  PubMed  Google Scholar 

Gao P, Xia JH, Sipeky C et al (2018) Biology and clinical implications of the 19q13 aggressive prostate cancer susceptibility locus. Cell 174(3):576-589.e18. https://doi.org/10.1016/j.cell.2018.06.003

Article  CAS  PubMed  PubMed Central  Google Scholar 

Germain ND, Chung WK, Sarmiere PD (2023) RNA interference (RNAi)-based therapeutics for treatment of rare neurologic diseases. Mol Aspects Med 91:101148. https://doi.org/10.1016/j.mam.2022.101148

Article  CAS  PubMed  Google Scholar 

Gong J, Mei S, Liu C et al (2018a) PancanQTL: systematic identification of cis-eQTLs and trans-eQTLs in 33 cancer types. Nucl Acids Res 46(D1):D971-d976. https://doi.org/10.1093/nar/gkx861

Article  CAS  PubMed  Google Scholar 

Gong J, Tian J, Lou J et al (2018b) A polymorphic MYC response element in KBTBD11 influences colorectal cancer risk, especially in interaction with an MYC-regulated SNP rs6983267. Ann Oncol Off J Eur Soc Med Oncol 29(3):632–639. https://doi.org/10.1093/annonc/mdx789

Article  CAS  Google Scholar 

Gupta N, Gaikwad S, Kaushik I, Wright SE, Markiewski MM, Srivastava SK (2021) Atovaquone suppresses triple-negative breast tumor growth by reducing immune-suppressive cells. Int J Mol Sci. https://doi.org/10.3390/ijms22105150

Article  PubMed  PubMed Central  Google Scholar 

Hormozdiari F, Kostem E, Kang EY, Pasaniuc B, Eskin E (2014) Identifying causal variants at loci with multiple signals of association. Genetics 198(2):497–508. https://doi.org/10.1534/genetics.114.167908

Article  CAS  PubMed  PubMed Central  Google Scholar 

Howie BN, Donnelly P, Marchini J (2009) A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet 5(6):e1000529. https://doi.org/10.1371/journal.pgen.1000529

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hunecke D, Spanel R, Länger F, Nam SW, Borlak J (2012) MYC-regulated genes involved in liver cell dysplasia identified in a transgenic model of liver cancer. J Pathol 228(4):520–533. https://doi.org/10.1002/path.4059

Article  CAS  PubMed  Google Scholar 

Ju W, Zheng R, Zhang S et al (2023) Cancer statistics in Chinese older people, 2022: current burden, time trends, and comparisons with the US, Japan, and the Republic of Korea. Sci China Life Sci 66(5):1079–1091. https://doi.org/10.1007/s11427-022-2218-x

Article  PubMed  Google Scholar 

Kara G, Calin GA, Ozpolat B (2022) RNAi-based therapeutics and tumor targeted delivery in cancer. Adv Drug Deliv Rev 182:114113. https://doi.org/10.1016/j.addr.2022.114113

Article  CAS  PubMed  Google Scholar 

Kondoh N, Schweinfest CW, Henderson KW, Papas TS (1992) Differential expression of S19 ribosomal protein, laminin-binding protein, and human lymphocyte antigen class I messenger RNAs associated with colon carcinoma progression and differentiation. Can Res 52(4):791–796

CAS  Google Scholar 

Li B, Cai Y, Chen C et al (2023) Genetic variants that impact alternative polyadenylation in cancer represent candidate causal risk loci. Can Res 83(21):3650–3666. https://doi.org/10.1158/0008-5472.Can-23-0251

Article  CAS  Google Scholar 

Liu BW, Sun N, Lin H et al (2023) The p53/ZEB1-PLD3 feedback loop regulates cell proliferation in breast cancer. Cell Death Dis 14(11):751. https://doi.org/10.1038/s41419-023-06271-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu Y, Kweon SS, Tanikawa C et al (2019) Large-scale genome-wide association study of east asians identifies loci associated with risk for colorectal cancer. Gastroenterology 156(5):1455–1466. https://doi.org/10.1053/j.gastro.2018.11.066

Article  PubMed  Google Scholar 

Maller JB, McVean G, Byrnes J et al (2012) Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat Genet 44(12):1294–1301. https://doi.org/10.1038/ng.2435

Article  CAS  PubMed  PubMed Central  Google Scholar 

McDonald ER 3rd, de Weck A, Schlabach MR et al (2017) Project DRIVE: a compendium of cancer dependencies and synthetic lethal relationships uncovered by large-scale. Deep RNAi Screen Cell 170(3):577-592.e10. https://doi.org/10.1016/j.cell.2017.07.005

Article  CAS  PubMed  Google Scholar 

Paulson KE, Rieger-Christ K, McDevitt MA et al (2007) Alterations of the HBP1 transcriptional repressor are associated with invasive breast cancer. Can Res 67(13):6136–6145. https://doi.org/10.1158/0008-5472.Can-07-0567

Article  CAS  Google Scholar 

Safaeian M, Hildesheim A, Gonzalez P et al (2012) Single nucleotide polymor

留言 (0)

沒有登入
gif