Ingle JN, Xie F, Ellis MJ, Goss PE, Shepherd LE, Chapman J-AW, Chen BE, Kubo M, Furukawa Y, Momozawa Y, et al. Genetic polymorphisms in the long noncoding RNA MIR2052HG offer a pharmacogenomic basis for the response of breast Cancer patients to aromatase inhibitor therapy. Cancer Res. 2016;76(23):7012–23.
Article CAS PubMed PubMed Central Google Scholar
Ingle JN, Liu M, Wickerham DL, Schaid DJ, Wang L, Mushiroda T, Kubo M, Costantino JP, Vogel VG, Paik S, et al. Selective estrogen receptor modulators and pharmacogenomic variation in ZNF423 regulation of BRCA1 expression: individualized breast Cancer Prevention. Cancer Discov. 2013;3(7):812–25.
Article CAS PubMed PubMed Central Google Scholar
Ingle JN, Schaid DJ, Goss PE, Liu M, Mushiroda T, Chapman J-AW, Kubo M, Jenkins GD, Batzler A, Shepherd L, et al. Genome-wide associations and functional genomic studies of Musculoskeletal adverse events in women receiving aromatase inhibitors. J Clin Oncol. 2010;28(31):4674–82.
Article CAS PubMed PubMed Central Google Scholar
Liu M, Goss PE, Ingle JN, Kubo M, Furukawa Y, Batzler A, Jenkins GD, Carlson EE, Nakamura Y, Schaid DJ, et al. Aromatase inhibitor-Associated Bone fractures: a Case-Cohort GWAS and Functional Genomics. Mol Endocrinol. 2014;28(10):1740–51.
Article PubMed PubMed Central Google Scholar
Ingle JN, Kalari KR, Barman P, Shepherd LE, Ellis MJ, Goss PE, Buzdar AU, Robson ME, Cairns J, Carlson EE, et al. Single-nucleotide polymorphism biomarkers of adjuvant anastrozole-induced estrogen suppression in early breast cancer. Pharmacogenet Genomics. 2020;31(1):1–9.
Collins LC, Cole KS, Marotti JD, Hu R, Schnitt SJ, Tamimi RM. Androgen receptor expression in breast cancer in relation to molecular phenotype: results from the nurses’ Health Study. Mod Pathol. 2011;24(7):924–31.
Article PubMed PubMed Central Google Scholar
Vera-Badillo FE, Templeton AJ, de Gouveia P, Diaz-Padilla I, Bedard PL, Al-Mubarak M, Seruga B, Tannock IF, Ocana A, Amir E. Androgen receptor expression and outcomes in early breast Cancer: a systematic review and Meta-analysis. JNCI J Natl Cancer Inst. 2013;106(1):djt319–319.
Astvatsaturyan K, Yue Y, Walts AE, Bose S. Androgen receptor positive triple negative breast cancer: clinicopathologic, prognostic, and predictive features. PLoS ONE 2018, 13(6).
Garay JP, Park BH. Androgen receptor as a targeted therapy for breast cancer. Am J Cancer Res. 2012;2(4):434–45.
CAS PubMed PubMed Central Google Scholar
Takagi K, Miki Y, Nagasaki S, Hirakawa H, Onodera Y, Akahira J-i, Ishida T, Watanabe M, Kimijima I, Hayashi S-, et al. Increased intratumoral androgens in human breast carcinoma following aromatase inhibitor exemestane treatment. Endocrine-related Cancer. 2010;17(2):415–30.
Article CAS PubMed Google Scholar
Baumgart J, Nilsson K, Stavreus Evers A, Kunovac Kallak T, Kushnir MM, Bergquist J. Sundström Poromaa I: androgen levels during adjuvant endocrine therapy in postmenopausal breast cancer patients. Climacteric. 2013;17(1):48–54.
Kennedy BJ. Fluoxymesterone therapy in advanced breast Cancer. N Engl J Med. 1958;259(14):673–5.
Article CAS PubMed Google Scholar
GOLDENBERG IS: Testosterone Propionate Therapy in Breast Cancer. Jama. 1964, 188(12).
Krop I, Abramson V, Colleoni M, Traina T, Holmes F, Garcia-Estevez L, Hart L, Awada A, Zamagni C, Morris PG, et al. A randomized placebo controlled phase II trial evaluating exemestane with or without Enzalutamide in patients with hormone receptor–positive breast Cancer. Clin Cancer Res. 2020;26(23):6149–57.
Article CAS PubMed Google Scholar
Wei L, Gao H, Yu J, Zhang H, Nguyen TTL, Gu Y, Passow MR, Carter JM, Qin B, Boughey JC, et al. Pharmacological targeting of androgen receptor elicits context-specific effects in Estrogen receptor–positive breast Cancer. Cancer Res. 2023;83(3):456–70.
Article CAS PubMed Google Scholar
Liu D, Nguyen TTL, Gao H, Huang H, Kim DC, Sharp B, Ye Z, Lee J-H, Coombes BJ, Ordog T, et al. TCF7L2 lncRNA: a link between bipolar disorder and body mass index through glucocorticoid signaling. Mol Psychiatry. 2021;26(12):7454–64.
Article CAS PubMed PubMed Central Google Scholar
Mangravite LM, Engelhardt BE, Medina MW, Smith JD, Brown CD, Chasman DI, Mecham BH, Howie B, Shim H, Naidoo D, et al. A statin-dependent QTL for GATM expression is associated with statin-induced myopathy. Nature. 2013;502(7471):377–80.
Article CAS PubMed PubMed Central Google Scholar
Arloth J, Bogdan R, Weber P, Frishman G, Menke A, Wagner Klaus V, Balsevich G, Schmidt Mathias V, Karbalai N, Czamara D, et al. Genetic differences in the Immediate Transcriptome response to stress predict risk-related brain function and Psychiatric disorders. Neuron. 2015;86(5):1189–202.
Article CAS PubMed PubMed Central Google Scholar
Nguyen Thanh Thanh L, Gao H, Liu D, Philips TJ, Ye Z, Lee J-H, Shi G-x, Copenhaver K, Zhang L, Wei L, et al. Glucocorticoids unmask silent non-coding genetic risk variants for common diseases. Nucleic Acids Res. 2022;50(20):11635–53.
Article CAS PubMed Central Google Scholar
Udhane V, Maranto C, Hoang DT, Gu L, Erickson A, Devi S, Talati PG, Banerjee A, Iczkowski KA, Jacobsohn K, et al. Enzalutamide-Induced feed-Forward Signaling Loop promotes therapy-resistant prostate Cancer Growth providing an exploitable molecular target for Jak2 inhibitors. Mol Cancer Ther. 2020;19(1):231–46.
Article CAS PubMed Google Scholar
Yuan F, Hankey W, Wu D, Wang H, Somarelli J, Armstrong AJ, Huang J, Chen Z, Wang Q. Molecular determinants for enzalutamide-induced transcription in prostate cancer. Nucleic Acids Res. 2019;47(19):10104–14.
Article CAS PubMed PubMed Central Google Scholar
Taavitsainen S, Engedal N, Cao S, Handle F, Erickson A, Prekovic S, Wetterskog D, Tolonen T, Vuorinen EM, Kiviaho A et al. Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse. Nat Commun 2021, 12(1).
Niu N, Qin Y, Fridley BL, Hou J, Kalari KR, Zhu M, Wu T-Y, Jenkins GD, Batzler A, Wang L. Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. Genome Res. 2010;20(11):1482–92.
Article CAS PubMed PubMed Central Google Scholar
Cairns J, Ingle JN, Dudenkov TM, Kalari KR, Carlson EE, Na J, Buzdar AU, Robson ME, Ellis MJ, Goss PE et al. Pharmacogenomics of aromatase inhibitors in postmenopausal breast cancer and additional mechanisms of anastrozole action. JCI Insight 2020, 5(16).
Sollis E, Mosaku A, Abid A, Buniello A, Cerezo M, Gil L, Groza T, Güneş O, Hall P, Hayhurst J, et al. The NHGRI-EBI GWAS catalog: knowledgebase and deposition resource. Nucleic Acids Res. 2023;51(D1):D977–85.
Article CAS PubMed Google Scholar
Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, Batut P, Chaisson M, Gingeras TR. STAR: ultrafast universal RNA-seq aligner. Bioinformatics. 2013;29(1):15–21.
Article CAS PubMed Google Scholar
Anders S, Pyl PT, Huber W. HTSeq–a Python framework to work with high-throughput sequencing data. Bioinformatics. 2014;31(2):166–9.
Article PubMed PubMed Central Google Scholar
Robinson MD, McCarthy DJ, Smyth GK. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2009;26(1):139–40.
Article PubMed PubMed Central Google Scholar
Chang CC, Chow CC, Tellier LCAM, Vattikuti S, Purcell SM, Lee JJ. Second-generation PLINK: rising to the challenge of larger and richer datasets. GigaScience 2015, 4(1).
Shabalin AA. Matrix eQTL: ultra fast eQTL analysis via large matrix operations. Bioinformatics. 2012;28(10):1353–8.
Article CAS PubMed PubMed Central Google Scholar
Hammal F, de Langen P, Bergon A, Lopez F, Ballester B. ReMap 2022: a database of Human, Mouse, Drosophila and Arabidopsis regulatory regions from an integrative analysis of DNA-binding sequencing experiments. Nucleic Acids Res. 2022;50(D1):D316–25.
Article CAS PubMed Google Scholar
Prlic A, Lawrence M, Huber W, Pagès H, Aboyoun P, Carlson M, Gentleman R, Morgan MT, Carey VJ. Software for Computing and Annotating genomic ranges. PLoS Comput Biol 2013, 9(8).
Ward LD, Kellis M. HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res. 2011;40(D1):D930–4.
留言 (0)