Autophagy alterations in obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease: the evidence from human studies

Riazi K, Azhari H, Charette JH, Underwood FE, King JA, Afshar EE, Swain MG, Congly SE, Kaplan GG, Shaheen AA (2022) The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol 7:851–861

Article  PubMed  Google Scholar 

Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, Mullany EC, Biryukov S, Abbafati C, Abera SF, Abraham JP, Abu-Rmeileh NM, Achoki T, AlBuhairan FS, Alemu ZA, Alfonso R, Ali MK, Ali R, Guzman NA, Ammar W, Anwari P, Banerjee A, Barquera S, Basu S, Bennett DA, Bhutta Z, Blore J, Cabral N, Nonato IC, Chang JC, Chowdhury R, Courville KJ, Criqui MH, Cundiff DK, Dabhadkar KC, Dandona L, Davis A, Dayama A, Dharmaratne SD, Ding EL, Durrani AM, Esteghamati A, Farzadfar F, Fay DF, Feigin VL, Flaxman A, Forouzanfar MH, Goto A, Green MA, Gupta R, Hafezi-Nejad N, Hankey GJ, Harewood HC, Havmoeller R, Hay S, Hernandez L, Husseini A, Idrisov BT, Ikeda N, Islami F, Jahangir E, Jassal SK, Jee SH, Jeffreys M, Jonas JB, Kabagambe EK, Khalifa SE, Kengne AP, Khader YS, Khang YH, Kim D, Kimokoti RW, Kinge JM, Kokubo Y, Kosen S, Kwan G, Lai T, Leinsalu M, Li Y, Liang X, Liu S, Logroscino G, Lotufo PALu, Ma Y, Mainoo J, Mensah NK, Merriman GA, Mokdad TR, Moschandreas AH, Naghavi J, Naheed M, Nand A, Narayan D, Nelson KM, Neuhouser EL, Nisar ML, Ohkubo MI, Oti T, Pedroza SO et al (2014) Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 384:766–781

Article  PubMed  PubMed Central  Google Scholar 

Collaborators GBDD (2023) Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Lancet 402:203–234

Article  Google Scholar 

Boutari C, Mantzoros CS (2022) A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on. Metabolism 133:155217

Article  CAS  PubMed  PubMed Central  Google Scholar 

Organization, W. H. (2022) WHO European Regional Obesity Report 2022

Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, Stein C, Basit A, Chan JCN, Mbanya JC, Pavkov ME, Ramachandaran A, Wild SH, James S, Herman WH, Zhang P, Bommer C, Kuo S, Boyko EJ, Magliano DJ (2022) IDF Diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract 183:109119

Article  PubMed  Google Scholar 

Lee YH, Cho Y, Lee BW, Park CY, Lee DH, Cha BS, Rhee EJ (2019) Nonalcoholic fatty liver disease in diabetes. Part I: epidemiology and diagnosis. Diabetes Metab J 43:31–45

Article  PubMed  Google Scholar 

Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M (2016) Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology 64:73–84

Article  PubMed  Google Scholar 

Loomba R, Friedman SL, Shulman GI (2021) Mechanisms and disease consequences of nonalcoholic fatty liver disease. Cell 184:2537–2564

Article  CAS  PubMed  Google Scholar 

Burgos-Moron E, Abad-Jimenez Z, Maranon AM, Iannantuoni F, Escribano-Lopez I, Lopez-Domenech S, Salom C, Jover A, Mora V, Roldan I, Sola E, Rocha M, Victor VM (2019) Relationship between oxidative stress, ER stress, and inflammation in type 2 diabetes: the battle continues. J Clin Med 8:1385

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rabinowitz JD, White E (2010) Autophagy and metabolism. Science 330:1344–1348

Article  CAS  PubMed  PubMed Central  Google Scholar 

Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cadwell K, Cecconi F, Choi AMK, Choi ME, Chu CT, Codogno P, Colombo MI, Cuervo AM, Deretic V, Dikic I, Elazar Z, Eskelinen EL, Fimia GM, Gewirtz DA, Green DR, Hansen M, Jaattela M, Johansen T, Juhasz G, Karantza V, Kraft C, Kroemer G, Ktistakis NT, Kumar S, Lopez-Otin C, Macleod KF, Madeo F, Martinez J, Melendez A, Mizushima N, Munz C, Penninger JM, Perera RM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Sadoshima J, Santambrogio L, Scorrano L, Simon HU, Simon AK, Simonsen A, Stolz A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Galluzzi L, Pietrocola F (2021) Autophagy in major human diseases. EMBO J 40:e108863

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ohsumi Y (2014) Historical landmarks of autophagy research. Cell Res 24:9–23

Article  CAS  PubMed  Google Scholar 

Kitada M, Koya D (2021) Autophagy in metabolic disease and ageing. Nat Rev Endocrinol 17:647–661

Article  PubMed  Google Scholar 

Yorimitsu T, Klionsky DJ (2005) Autophagy: molecular machinery for self-eating. Cell Death Differ 12(Suppl 2):1542–1552

Article  CAS  PubMed  Google Scholar 

Glick D, Barth S, Macleod KF (2010) Autophagy: cellular and molecular mechanisms. J Pathol 221:3–12

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu L, Chen Y, Tooze SA (2018) Autophagy pathway: cellular and molecular mechanisms. Autophagy 14:207–215

Article  CAS  PubMed  Google Scholar 

Parzych KR, Klionsky DJ (2014) An overview of autophagy: morphology, mechanism, and regulation. Antioxid Redox Signal 20:460–473

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao W, Li J, Yang K, Cao D (2021) An overview of autophagy: mechanism, regulation and research progress. Bull Cancer 108:304–322

Article  PubMed  Google Scholar 

Tabibzadeh S (2023) Role of autophagy in aging: the good, the bad, and the ugly. Aging Cell 22:e13753

Article  CAS  PubMed  Google Scholar 

Moulis M, Vindis C (2018) Autophagy in metabolic age-related human diseases. Cells 7:149

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anding AL, Baehrecke EH (2017) Cleaning house: selective autophagy of organelles. Dev Cell 41:10–22

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mulcahy Levy JM, Thorburn A (2020) Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients. Cell Death Differ 27:843–857

Article  PubMed  Google Scholar 

Zhang J (2015) Teaching the basics of autophagy and mitophagy to redox biologists–mechanisms and experimental approaches. Redox Biol 4:242–259

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM (2006) Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell 11:859–871

Article  CAS  PubMed  Google Scholar 

Cybulski N, Hall MN (2009) TOR complex 2: a signaling pathway of its own. Trends Biochem Sci 34:620–627

Article  CAS  PubMed  Google Scholar 

Sun Y, Wang H, Qu T, Luo J, An P, Ren F, Luo Y, Li Y (2023) mTORC2: a multifaceted regulator of autophagy. Cell Commun Signal 21:4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou B, Kreuzer J, Kumsta C, Wu L, Kamer KJ, Cedillo L, Zhang Y, Li S, Kacergis MC, Webster CM, Fejes-Toth G, Naray-Fejes-Toth A, Das S, Hansen M, Haas W, Soukas AA (2019) Mitochondrial permeability uncouples elevated autophagy and lifespan extension. Cell 177(299–314):e16

Google Scholar 

Aspernig H, Heimbucher T, Qi W, Gangurde D, Curic S, Yan Y, Donner von Gromoff E, Baumeister R, Thien A (2019) Mitochondrial perturbations couple mTORC2 to autophagy in C. elegans. Cell Rep 29:1399-1409.e5

Article  CAS  PubMed  Google Scholar 

Kim J, Kundu M, Viollet B, Guan KL (2011) AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 13:132–141

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